Oxidative stress and visual system: a review.
alpha-lipoic acid (ALA)
antioxidants
retina and optic nerve aging
superoxide dismutase (SOD)
Journal
EXCLI journal
ISSN: 1611-2156
Titre abrégé: EXCLI J
Pays: Germany
ID NLM: 101299402
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
01
2022
accepted:
10
02
2022
entrez:
2
6
2022
pubmed:
3
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
Different types of tissues respond differently to the action of oxidative stress. The visual system is very sensitive to oxidative action due to continuous exposure to light. In consideration of the growing interest of scientific studies towards various compounds endowed with antioxidant and anti-inflammatory properties, we performed a review of the literature focusing on the use of some antioxidant molecules for the treatment of conditions affecting the visual system. In this study, we focused on the ability of two antioxidant agents, the small molecule α-lipoic acid (ALA) and the enzyme superoxide dismutase (SOD), to influence the neurodegenerative physiological processes related to aging and oxidative stress affecting the ocular segment. The literature data report that ALA and SOD can protect against neurodegenerative effects both the optic nerve and retina and, if administered together, they are able to lower the levels of oxidative stress, thus preventing neurodegeneration and reducing the apoptotic process.
Identifiants
pubmed: 35651654
doi: 10.17179/excli2022-4663
pii: 2022-4663
pmc: PMC9150018
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
544-553Informations de copyright
Copyright © 2022 Taurone et al.
Références
Methods Enzymol. 1999;299:83-8
pubmed: 9916199
Neuroscientist. 2010 Aug;16(4):435-52
pubmed: 20817920
Int J Immunopathol Pharmacol. 2018 Jan-Dec;31:394632017748841
pubmed: 29251013
Mutat Res. 1995 Feb;316(3):103-22
pubmed: 7862174
Oxid Med Cell Longev. 2016;2016:3565127
pubmed: 27247702
Gut. 2000 Jul;47(1):6-9
pubmed: 10861252
Mol Cell Biol. 1991 Feb;11(2):632-40
pubmed: 1899285
Am J Pathol. 1996 Jul;149(1):21-8
pubmed: 8686745
Curr Pharm Des. 2018;24(40):4726-4741
pubmed: 30644339
Nutr Res. 2015 Feb;35(2):107-17
pubmed: 25636674
Free Radic Biol Med. 2007 Sep 1;43(5):658-77
pubmed: 17664130
Am J Clin Nutr. 2018 Aug 1;108(2):381-387
pubmed: 29982448
Vet Med Int. 2011;2011:905153
pubmed: 21789267
Oxid Med Cell Longev. 2017;2017:6469138
pubmed: 28154734
Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):179-92, vii
pubmed: 18249249
Biochem Soc Symp. 1995;61:1-31
pubmed: 8660387
Free Radic Biol Med. 2009 Feb 15;46(4):492-501
pubmed: 19071211
Clin Sci (Lond). 2017 Dec 4;131(24):2865-2883
pubmed: 29203723
Biomed Pharmacother. 2017 Jun;90:935-946
pubmed: 28460429
Int Rev Neurobiol. 2007;82:397-406
pubmed: 17678974
Mol Med Rep. 2015 Feb;11(2):1384-90
pubmed: 25351602
Prog Retin Eye Res. 2018 Jan;62:24-37
pubmed: 28962928
Food Funct. 2017 Dec 13;8(12):4284-4305
pubmed: 29044265
Oxid Med Cell Longev. 2015;2015:504253
pubmed: 26180591
FEBS Lett. 2018 Mar;592(5):743-758
pubmed: 29106705
Naunyn Schmiedebergs Arch Pharmacol. 2005 Jan;371(1):44-53
pubmed: 15645293
Antioxid Redox Signal. 2015 Sep 1;23(7):643-8
pubmed: 25820114
Mol Aspects Med. 2012 Aug;33(4):418-35
pubmed: 22503691
React Oxyg Species (Apex). 2016;1(1):9-21
pubmed: 29707643
J Nutr Biochem. 2005 May;16(5):297-304
pubmed: 15866230
Chem Biol Interact. 2006 Mar 10;160(1):1-40
pubmed: 16430879
Immunol Res. 2019 Jun;67(2-3):280-289
pubmed: 31327149
Infect Disord Drug Targets. 2020;20(1):16-26
pubmed: 29952268
J Biol Regul Homeost Agents. 2013 Jan-Mar;27(1):197-209
pubmed: 23489699
Clin Anat. 2020 Mar;33(2):245-256
pubmed: 31595552
Int J Mol Sci. 2011;12(10):7114-62
pubmed: 22072939
PLoS One. 2012;7(8):e43089
pubmed: 22905206
Curr Eye Res. 2005 Sep;30(9):789-98
pubmed: 16146925
Arzneimittelforschung. 1992 Jun;42(6):829-31
pubmed: 1418040
Oxid Med Cell Longev. 2017;2017:9702820
pubmed: 28265339
Expert Opin Pharmacother. 2013 Sep;14(13):1829-38
pubmed: 23790257
Haematologica. 2006 Sep;91(9):1222-7
pubmed: 16956821
Vis Neurosci. 2003 Mar-Apr;20(2):97-107
pubmed: 12916732
Oncotarget. 2016 Jul 19;7(29):44879-44905
pubmed: 27270647
Eur J Biochem. 1993 Jul 15;215(2):213-9
pubmed: 7688300
Curr Neuropharmacol. 2009 Mar;7(1):65-74
pubmed: 19721819
Am J Ther. 2016 Jan-Feb;23(1):e98-117
pubmed: 21048433
J Neurochem. 2018 Mar;144(5):617-633
pubmed: 29210074
Biochem J. 2001 Aug 1;357(Pt 3):593-615
pubmed: 11463332
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2278-83
pubmed: 11226230
Apoptosis. 2000 Nov;5(5):415-8
pubmed: 11256882
Biochem J. 1993 Jun 1;292 ( Pt 2):605-8
pubmed: 8389142
Nat Commun. 2014 Mar 19;5:3446
pubmed: 24647101
Eur Rev Med Pharmacol Sci. 2020 Oct;24(20):10319-10329
pubmed: 33155187
Drugs R D. 2012 Mar 1;12(1):29-34
pubmed: 22329607
Nutrients. 2016 Apr 05;8(4):200
pubmed: 27058553
Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7703-7712
pubmed: 31539163
Front Neurol. 2021 Nov 16;12:732176
pubmed: 34899560
Nat Rev Genet. 2010 Apr;11(4):273-84
pubmed: 20212494
Int J Exp Pathol. 2012 Dec;93(6):401-5
pubmed: 23082958
Clin Sci (Lond). 2015 Jul;129(2):199-216
pubmed: 25927680
Nat Genet. 1995 Dec;11(4):376-81
pubmed: 7493016
Redox Biol. 2015;4:180-3
pubmed: 25588755