Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4
CD4+T cell
PPARγ
ROS
anti-inflammation
astilbin
cytochrome P450 1B1
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
01
2022
accepted:
29
04
2022
entrez:
2
6
2022
pubmed:
3
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
Astilbin, as a compound of flavonoids, exerts anti-inflammation, antioxidation, and immune-suppression activities. Decreased activation of NF-κB and p38 MAPK and increased activation of SOCS3 and AMPK have been found in astilbin-treated cells. However, what molecules are docked by astilbin to initiate signaling cascades and result in functional changes remains unknown. In the study, we found that astilbin efficiently suppressed TNF-α production and increased CCR9 and CD36 expression of CD4
Identifiants
pubmed: 35652039
doi: 10.3389/fphar.2022.848957
pii: 848957
pmc: PMC9150850
doi:
Types de publication
Journal Article
Langues
eng
Pagination
848957Informations de copyright
Copyright © 2022 Ding, Lu, Wang, Xiang, Hu, Lin, Ding, Xiao and Gong.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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