The ShGlom
CKD—chronic kidney disease
compound
differentiation
glomerulus
podocyte
screening
vitamin D3
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
12
2021
accepted:
13
04
2022
entrez:
2
6
2022
pubmed:
3
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is a major public health burden affecting more than 500 million people worldwide. Podocytopathies are the main cause for the majority of CKD cases due to pathogenic morphological as well as molecular biological alterations of postmitotic podocytes. Podocyte de-differentiation is associated with foot process effacement subsequently leading to proteinuria. Since currently no curative drugs are available, high throughput screening methods using a small number of animals are a promising and essential tool to identify potential drugs against CKD in the near future. Our study presents the implementation of the already established mouse Glom
Identifiants
pubmed: 35652093
doi: 10.3389/fcell.2022.838086
pii: 838086
pmc: PMC9150175
doi:
Types de publication
Journal Article
Langues
eng
Pagination
838086Informations de copyright
Copyright © 2022 Ristov, Lange, Artelt, Nath, Kuss, Gehrig, Lindenmeyer, Cohen, Gul, Endlich, Völker and Endlich.
Déclaration de conflit d'intérêts
JG is an employee of the DITABIS AG, Pforzheim, Germany and the ACQUIFER Imaging GmbH, Heidelberg, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Am Soc Nephrol. 2005 Nov;16(11):3247-55
pubmed: 16207825
J Chin Med Assoc. 2018 Aug;81(8):691-698
pubmed: 29748075
Clin J Am Soc Nephrol. 2016 Mar 7;11(3):536-8
pubmed: 26553796
Kidney Int. 2006 Sep;70(5):892-900
pubmed: 16820792
J Am Soc Nephrol. 2014 Jan;25(1):92-104
pubmed: 24029422
Semin Nephrol. 2016 Jul;36(4):273-82
pubmed: 27475658
Kidney Int. 2000 Sep;58(3):972-80
pubmed: 10972661
Br J Pharmacol. 2017 Jan;174(2):163-176
pubmed: 27858997
Nucleic Acids Res. 2021 Jan 8;49(D1):D394-D403
pubmed: 33290554
Cancer Prev Res (Phila). 2013 May;6(5):483-94
pubmed: 23503652
Br J Pharmacol. 2015 Jul;172(13):3189-93
pubmed: 25964986
Kidney Int. 2004 Jul;66(1):91-101
pubmed: 15200416
J Clin Endocrinol Metab. 2011 Jan;96(1):53-8
pubmed: 21118827
Ren Fail. 2010;32(8):969-77
pubmed: 20722565
Kidney360. 2020 Dec 22;2(2):385-397
pubmed: 35373019
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5682-7
pubmed: 16581909
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genome Biol. 2014;15(12):550
pubmed: 25516281
Dtsch Med Wochenschr. 2015 Nov;140(22):1661-6
pubmed: 26536642
J Am Soc Nephrol. 2012 Dec;23(12):1977-86
pubmed: 23123403
Front Endocrinol (Lausanne). 2014 Oct 01;5:148
pubmed: 25324828
Dermatol Ther. 2010 Jan-Feb;23(1):2-12
pubmed: 20136904
Kidney Int. 2002 Jan;61(1):133-40
pubmed: 11786093
J Cell Mol Med. 2017 Oct;21(10):2599-2609
pubmed: 28664547
Br J Pharmacol. 2010 Aug;160(7):1577-9
pubmed: 20649561
Kidney Int. 2007 Jun;71(12):1205-14
pubmed: 17410103
Oncotarget. 2017 May 23;8(21):35390-35402
pubmed: 28427151
Hum Mol Genet. 2001 Jan 1;10(1):1-8
pubmed: 11136707
Cell Chem Biol. 2018 Feb 15;25(2):126-127
pubmed: 29452609
Trends Mol Med. 2007 Sep;13(9):396-403
pubmed: 17766183
Int J Mol Sci. 2020 Sep 07;21(18):
pubmed: 32906849
Am J Physiol Renal Physiol. 2000 Dec;279(6):F1027-32
pubmed: 11097620
Kidney Int. 2007 Aug;72(3):247-59
pubmed: 17568785
Physiol Rev. 2016 Jan;96(1):365-408
pubmed: 26681795
Lancet. 2020 Feb 29;395(10225):709-733
pubmed: 32061315
J Cell Mol Med. 2019 Jul;23(7):4839-4843
pubmed: 31066165
J Am Soc Nephrol. 2015 Nov;26(11):2741-52
pubmed: 25858967
Nephrol Dial Transplant. 2009 Oct;24(10):3006-12
pubmed: 19474283
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21
pubmed: 11309499
J Investig Med. 2017 Dec;65(8):1093-1101
pubmed: 28935636
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
J Am Soc Nephrol. 2014 Nov;25(11):2559-72
pubmed: 24925724
Clin Nephrol. 2016 Nov;86 (2016)(11):236-241
pubmed: 27719737
J Biol Chem. 2011 Sep 16;286(37):32011-7
pubmed: 21803771