Bisacodyl Limits Chikungunya Virus Replication
antiviral screen
bisacodyl
chikungunya virus
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 06 2022
21 06 2022
Historique:
pubmed:
3
6
2022
medline:
24
6
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
Identifying novel antivirals requires significant time and resource investment, and the continuous threat of viruses to human health necessitates commitment to antiviral identification and development. Developing antivirals requires years of research and validation, and recent outbreaks have highlighted the need for preparedness in counteracting pandemics. One way to facilitate development is to repurpose molecules already used clinically. By screening such compounds, we can accelerate antiviral development. Here, we screened compounds from the National Institutes of Health's Developmental Therapeutic Program for activity against chikungunya virus, an alphavirus that is responsible for a significant outbreak in the Americas in 2013. Using this library, we identified several compounds with known antiviral activity, as well as several novel antivirals. Given its favorable
Identifiants
pubmed: 35652314
doi: 10.1128/aac.00292-22
pmc: PMC9211418
doi:
Substances chimiques
Antiviral Agents
0
Bisacodyl
10X0709Y6I
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0029222Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM138199
Pays : United States
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