Replication of the abnormal niacin response in first episode psychosis measured using laser Doppler flowmeter.
Doppler flowmeter
endophenotype
niacin
psychosis
schizophrenia
Journal
Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
ISSN: 1758-5872
Titre abrégé: Asia Pac Psychiatry
Pays: Australia
ID NLM: 101506757
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
24
02
2022
received:
22
12
2021
accepted:
18
05
2022
pubmed:
3
6
2022
medline:
9
11
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
Impaired sensitivity of the skin flush response to niacin is found in approximately 30% of patients with schizophrenia. Although the niacin response abnormality (NRA) may serve as a useful endophenotype for schizophrenia, few studies have directly replicated NRA in patients with first-episode psychosis (FEP). In total, 204 patients with FEP, 16 with psychotic mood disorder (PMD), and 68 healthy controls (HC) were included. The log In total, 13.7% of the FEP, 12.5% of the PMD, and 7.4% of the HC group met the definition of NRA. Significant differences were found in the log These data represent the NRA in patients with FEP, defining a small subgroup of patients with early-phase psychosis possessing a clinically significant phospholipid-signaling defect.
Substances chimiques
Niacin
2679MF687A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12516Subventions
Organisme : Clinical Research Center at Shanghai Jiaotong University School of Medicine
ID : DLY201817
Organisme : Clinical Research Center at Shanghai Jiaotong University School of Medicine
ID : 20190102
Organisme : National Natural Science Foundation of China
ID : 82171544
Organisme : National Natural Science Foundation of China
ID : 81971251
Organisme : National Natural Science Foundation of China
ID : 81671329
Organisme : National Natural Science Foundation of China
ID : 81871050
Organisme : Project of the Key Discipline Construction, Shanghai 3-Year Public Health Action Plan
ID : GWV-10.1-XK18
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 19441907800
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 16ZR1430500
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 19ZR1445200
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 17411953100
Organisme : Shanghai Clinical Research Center for Mental Health
ID : 19MC1911100
Organisme : Shanghai Municipal Science and Technology Major Project
ID : 2018SHZDZX01
Organisme : Shanghai Municipal Science and Technology Major Project
ID : 2018SHZDZX05
Organisme : The Clinical Research Center at Shanghai Mental Health Center
ID : CRC2018ZD01
Organisme : The Clinical Research Center at Shanghai Mental Health Center
ID : CRC2018ZD04
Informations de copyright
© 2022 John Wiley & Sons Australia, Ltd.
Références
Alqarni, A., Mitchell, T. W., McGorry, P. D., Nelson, B., Markulev, C., Yuen, H. P., Schafer, M. R., Berger, M., Mossaheb, N., Schlogelhofer, M., Smesny, S., Hickie, I. B., Berger, G. E., Chen, E. Y. H., de Haan, L., Nieman, D. H., Nordentoft, M., Riecher-Rossler, A., Verma, S., … Amminger, G. P. (2020). Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis. Schizophrenia Research, 226, 52-60. https://doi.org/10.1016/j.schres.2019.08.033
Amminger, G. P., Nelson, B., Markulev, C., Yuen, H. P., Schafer, M. R., Berger, M., Mossaheb, N., Schlogelhofer, M., Smesny, S., Hickie, I. B., Berger, G. E., Chen, E. Y. H., de Haan, L., Nieman, D. H., Nordentoft, M., Riecher-Rossler, A., Verma, S., Thompson, A., Yung, A. R., & McGorry, P. D. (2020). The NEURAPRO biomarker analysis: Long-chain omega-3 fatty acids improve 6-month and 12-month outcomes in youths at ultra-high risk for psychosis. Biological Psychiatry, 87(3), 243-252. https://doi.org/10.1016/j.biopsych.2019.08.030
Andersen, J., Larsen, J. K., Schultz, V., Nielsen, B. M., Korner, A., Behnke, K., Munk-Andersen, E., Butler, B., Allerup, P., & Bech, P. (1989). The brief psychiatric rating scale. Dimension of schizophrenia-reliability and construct validity. Psychopathology, 22(2-3), 168-176. https://doi.org/10.1159/000284591
Berger, G. E., Smesny, S., Schafer, M. R., Milleit, B., Langbein, K., Hipler, U. C., Milleit, C., Klier, C. M., Schlogelhofer, M., Holub, M., Holzer, I., Berk, M., McGorry, P. D., Sauer, H., & Amminger, G. P. (2016). Niacin skin sensitivity is increased in adolescents at ultra-high risk for psychosis. PLoS One, 11(2), e0148429. https://doi.org/10.1371/journal.pone.0148429
Chang, S. S., Liu, C. M., Lin, S. H., Hwu, H. G., Hwang, T. J., Liu, S. K., Hsieh, M. H., Guo, S. C., & Chen, W. J. (2009). Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: The effect of genetic loading. Schizophrenia Bulletin, 35(1), 213-221. https://doi.org/10.1093/schbul/sbm153
Downs, J., Dean, H., Lechler, S., Sears, N., Patel, R., Shetty, H., Hotopf, M., Ford, T., Kyriakopoulos, M., Diaz-Caneja, C. M., Arango, C., MacCabe, J. H., Hayes, R. D., & Pina-Camacho, L. (2019). Negative symptoms in early-onset psychosis and their association with antipsychotic treatment failure. Schizophrenia Bulletin, 45(1), 69-79. https://doi.org/10.1093/schbul/sbx197
Glen, A. I., Cooper, S. J., Rybakowski, J., Vaddadi, K., Brayshaw, N., & Horrobin, D. F. (1996). Membrane fatty acids, niacin flushing and clinical parameters. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 55(1-2), 9-15. https://doi.org/10.1016/s0952-3278(96)90139-8
Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. The American Journal of Psychiatry, 160(4), 636-645. https://doi.org/10.1176/appi.ajp.160.4.636
Howes, O. D., & Kapur, S. (2014). A neurobiological hypothesis for the classification of schizophrenia: Type a (hyperdopaminergic) and type B (normodopaminergic). The British Journal of Psychiatry, 205(1), 1-3. https://doi.org/10.1192/bjp.bp.113.138578
Jablensky, A. (2006). Subtyping schizophrenia: Implications for genetic research. Molecular Psychiatry, 11(9), 815-836. https://doi.org/10.1038/sj.mp.4001857
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261-276.
Laugharne, J. D., Mellor, J. E., & Peet, M. (1996). Fatty acids and schizophrenia. Lipids, 31, S163-S165. https://doi.org/10.1007/BF02637070
Lien, Y. J., Huang, S. S., Liu, C. M., Hwu, H. G., Faraone, S. V., Tsuang, M. T., & Chen, W. J. (2013). A genome-wide quantitative linkage scan of niacin skin flush response in families with schizophrenia. Schizophrenia Bulletin, 39(1), 68-76. https://doi.org/10.1093/schbul/sbr054
Maclean, R., Ward, P. E., Glen, I., Roberts, S. J., & Ross, B. M. (2003). On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 27(6), 927-933. https://doi.org/10.1016/S0278-5846(03)00152-0
Messamore, E. (2003). Relationship between the niacin skin flush response and essential fatty acids in schizophrenia. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 69(6), 413-419. https://doi.org/10.1016/j.plefa.2003.08.013
Messamore, E. (2012). Niacin subsensitivity is associated with functional impairment in schizophrenia. Schizophrenia Research, 137(1-3), 180-184. https://doi.org/10.1016/j.schres.2012.03.001
Messamore, E. (2018). The niacin response biomarker as a schizophrenia endophenotype: A status update. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 136, 95-97. https://doi.org/10.1016/j.plefa.2017.06.014
Messamore, E., Hoffman, W. F., & Janowsky, A. (2003). The niacin skin flush abnormality in schizophrenia: A quantitative dose-response study. Schizophrenia Research, 62(3), 251-258. https://doi.org/10.1016/s0920-9964(02)00311-0
Messamore, E., Hoffman, W. F., & Yao, J. K. (2010). Niacin sensitivity and the arachidonic acid pathway in schizophrenia. Schizophrenia Research, 122(1-3), 248-256. https://doi.org/10.1016/j.schres.2010.03.025
Murakami, M., & Kudo, I. (2004). Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Progress in Lipid Research, 43(1), 3-35. https://doi.org/10.1016/s0163-7827(03)00037-7
Puri, B. K., Richardson, A. J., Counsell, S. J., Ward, P. E., Bustos, M. G., Hamilton, G., Bhakoo, K. K., & Treasaden, I. H. (2007). Negative correlation between cerebral inorganic phosphate and the volumetric niacin response in male patients with schizophrenia who have seriously and dangerously violently offended: A (31)P magnetic resonance spectroscopy study. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77(2), 97-99. https://doi.org/10.1016/j.plefa.2007.07.002
Salagre, E., Grande, I., Vieta, E., Mezquida, G., Cuesta, M. J., Moreno, C., Bioque, M., Lobo, A., Gonzalez-Pinto, A., Moreno, D. M., Corripio, I., Verdolini, N., Castro-Fornieles, J., Mane, A., Pinzon-Espinosa, J., Bonnin, C. D. M., Bernardo, M., & Group, P. (2020). Predictors of bipolar disorder versus schizophrenia diagnosis in a multicenter first psychotic episode cohort: Baseline characterization and a 12-month follow-up analysis. The Journal of Clinical Psychiatry, 81(6), 19m12996. https://doi.org/10.4088/JCP.19m12996
Sethom, M. M., Fares, S., Bouaziz, N., Melki, W., Jemaa, R., Feki, M., Hechmi, Z., & Kaabachi, N. (2010). Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 83(3), 131-136. https://doi.org/10.1016/j.plefa.2010.07.001
Smesny, S., Berger, G., Rosburg, T., Riemann, S., Riehemann, S., McGorry, P., & Sauer, H. (2003). Potential use of the topical niacin skin test in early psychosis-a combined approach using optical reflection spectroscopy and a descriptive rating scale. Journal of Psychiatric Research, 37(3), 237-247. https://doi.org/10.1016/s0022-3956(03)00006-2
Smesny, S., Klemm, S., Stockebrand, M., Grunwald, S., Gerhard, U. J., Rosburg, T., Sauer, H., & Blanz, B. (2007). Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77(2), 79-85. https://doi.org/10.1016/j.plefa.2007.08.006
Sun, L., Yang, X., Jiang, J., Hu, X., Qing, Y., Wang, D., Yang, T., Yang, C., Zhang, J., Yang, P., Wang, P., Cai, C., Wang, J., He, L., & Wan, C. (2018). Identification of the niacin-blunted subgroup of schizophrenia patients from mood disorders and healthy individuals in Chinese population. Schizophrenia Bulletin, 44(4), 896-907. https://doi.org/10.1093/schbul/sbx150
Tang, Y., Zhou, L., Gunnet, J. W., Wines, P. G., Cryan, E. V., & Demarest, K. T. (2006). Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A. Biochemical and Biophysical Research Communications, 345(1), 29-37. https://doi.org/10.1016/j.bbrc.2006.04.051
Tavares, H., Yacubian, J., Talib, L. L., Barbosa, N. R., & Gattaz, W. F. (2003). Increased phospholipase A2 activity in schizophrenia with absent response to niacin. Schizophrenia Research, 61(1), 1-6. https://doi.org/10.1016/s0920-9964(02)00281-5
Taylor, J. H., Calkins, M. E., & Gur, R. E. (2020). Markers of psychosis risk in the general population. Biological Psychiatry, 88(4), 337-348. https://doi.org/10.1016/j.biopsych.2020.02.002
Waldo, M. C. (1999). Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics. Schizophrenia Research, 40(1), 49-53. https://doi.org/10.1016/s0920-9964(99)00031-6
Yao, J. K., Dougherty, G. G., Jr., Gautier, C. H., Haas, G. L., Condray, R., Kasckow, J. W., Kisslinger, B. L., Gurklis, J. A., & Messamore, E. (2016). Prevalence and specificity of the abnormal niacin response: A potential Endophenotype marker in schizophrenia. Schizophrenia Bulletin, 42(2), 369-376. https://doi.org/10.1093/schbul/sbv130