Distinct forms of migration and mobility are differentially associated with HIV treatment adherence.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
pubmed:
3
6
2022
medline:
7
6
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
We examined whether human mobility was associated with antiretroviral treatment adherence, measured via antiretroviral hair concentrations. This is a cross-sectional analysis of adults on antiretroviral treatment in East Africa at baseline in an observational cohort study. Participants reported recent mobility (overnight travel) and histories of migration (changes of residence), including reasons, frequency/duration, and locations. Hair antiretroviral concentrations were analyzed using validated methods. We estimated associations between mobility and antiretroviral concentrations via linear regression adjusted for age, sex, region, years on treatment. Among 383 participants, half were women and the median age was 40. Among men, 25% reported recent work-related mobility, 30% nonwork mobility, and 11% migrated in the past year (mostly across district boundaries); among women, 6 and 57% reported work-related and nonwork mobility, respectively, and 8% recently migrated (mostly within district). Those reporting work-related trips 2 nights or less had 72% higher hair antiretroviral levels (P = 0.02) than those who did not travel for work; in contrast, nonwork mobility (any duration, vs. none) was associated with 24% lower levels (P = 0.06). Intra-district migrations were associated with 59% lower antiretroviral levels than nonmigrants (P = 0.003) while inter-district migrations were not (27% higher, P = 0.40). We found that localized/intra-district migration and nonwork travel-more common among women-were associated with lower adherence, potentially reflecting care interruptions or staying with family/friends unaware of the participants' status. In contrast, short work-related trips-more common among men-were associated with higher adherence, perhaps reflecting higher income. Adherence interventions may require tailoring by sex and forms of mobility.
Identifiants
pubmed: 35652674
doi: 10.1097/QAD.0000000000003213
pii: 00002030-202206010-00012
pmc: PMC9178682
mid: NIHMS1785369
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1021-1030Subventions
Organisme : NIMH NIH HHS
ID : P30 MH062246
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019105
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007339
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH119910
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH126808
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI098472
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104132
Pays : United States
Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
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