Peripheral endothelial and microvascular damage in liver cirrhosis: A systematic review and meta-analysis.
cardiovascular risk
cirrhosis
endothelial function
microcirculation
Journal
Microcirculation (New York, N.Y. : 1994)
ISSN: 1549-8719
Titre abrégé: Microcirculation
Pays: United States
ID NLM: 9434935
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
13
04
2022
received:
18
02
2022
accepted:
25
05
2022
pubmed:
3
6
2022
medline:
29
7
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
This is the first systematic review and meta-analysis of studies using any available functional method to examine differences in peripheral endothelial function between cirrhotic and non-cirrhotic individuals. Literature search involved PubMed, Web-of-Science, and Scopus databases, as well as gray literature sources. We included studies in adult subjects evaluating endothelial function with any semi-invasive or non-invasive functional method in patients with and without liver cirrhosis. From 3378 records initially retrieved, 15 studies with a total of 570 participants were included in the final quantitative meta-analysis. In six studies examining endothelial function with flow-mediated-dilatation, no differences between patients with cirrhosis and controls were evident (WMD: 1.33, 95%CI [-2.87, 5.53], I No differences in peripheral endothelial function assessed with semi-invasive or non-invasive functional methods exist between cirrhotic and non-cirrhotic subjects. The increasing co-existence of cardiovascular risk factors leading to impaired vascular reactivity in cirrhotic patients may partly explain these findings.
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12773Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383(9930):1749-1761.
Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151-171.
Scaglione S, Kliethermes S, Cao G, et al. The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol. 2015;49(8):690-696.
Global Burden of Liver Disease: A True Burden on Health Sciences and Economies!! | World Gastroenterology Organisation [Internet]. [cited 2021 Apr 26]. Available from: https://www.worldgastroenterology.org/publications/e-wgn/e-wgn-expert-point-of-view-articles-collection/global-burden-of-liver-disease-a-true-burden-on-health-sciences-and-economies
Polyzos SA, Kechagias S, Tsochatzis EA. Review article: non-alcoholic fatty liver disease and cardiovascular diseases: associations and treatment considerations. Aliment Pharmacol Ther. 2021;54(8):1013-1025.
Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. J Hepatol. 2007;46(5):927-934.
Jourde-Chiche N, Fakhouri F, Dou L, et al. Endothelium structure and function in kidney health and disease. Nat Rev Nephrol. 2019;15(2):87-108.
Vallance P, Moncada S. Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet. 1991;337(8744):776-778.
Berzigotti A, Erice E, Gilabert R, et al. Cardiovascular risk factors and systemic endothelial function in patients with cirrhosis. Am J Gastroenterol. 2013;108(1):75-82.
Davies T, Wythe S, O'Beirne J, Martin D, Gilbert-Kawai E. Review article: the role of the microcirculation in liver cirrhosis. Aliment Pharmacol Ther. 2017;46(9):825-835.
Thomson SJ, Cowan ML, Forton DM, et al. A study of muscle tissue oxygenation and peripheral microcirculatory dysfunction in cirrhosis using near infrared spectroscopy. Liver Int. 2010;30(3):463-471.
Cazzaniga M, Salerno F, Visentin S, Cirello I, Donarini C, Cugno M. Increased flow-mediated vasodilation in cirrhotic patients with ascites: relationship with renal resistive index: FMD in cirrhosis. Liver Int. 2008;28(10):1396-1401.
Theodorakopoulou MP, Schoina M, Sarafidis P. Assessment of endothelial and microvascular function in CKD: older and newer techniques, associated risk factors, and relations with outcomes. Am J Nephrol. 2020;11:1-19.
Theodorakopoulou MP, Alexandrou ME, Bakaloudi DR, et al. Endothelial dysfunction in COPD: a systematic review and meta-analysis of studies using different functional assessment methods. ERJ Open Res. 2021;7(2):00983-2020.
Ponziani FR, Funaro B, Lupascu A, et al. Minimal hepatic encephalopathy is associated with increased cerebral vascular resistance. A transcranial doppler ultrasound study. Sci Rep. 2019;9(1):15373.
Armentano RL, Arbeitman CR, Cymberknop LJ, Farro I, Viotti R, Cardelino J. Flow mediated dilation in cirrhosis: a pilot study in different stages of the disease. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) [Internet]. Honolulu (HI): IEEE; 2018 [cited 2020 Dec 30]. p. 4564-6. Available from: https://ieeexplore.ieee.org/document/8513192/
Hootman JM, Driban JB, Sitler MR, Harris KP, Cattano NM. Reliability and validity of three quality rating instruments for systematic reviews of observational studies. Res Synth Methods. 2011;2(2):110-118.
Herzog R, Álvarez-Pasquin MJ, Díaz C, et al. Are healthcare workers' intentions to vaccinate related to their knowledge, beliefs and attitudes? a systematic review. BMC Public Health. 2013;13:154.
Brito-Azevedo A, Perez RM, Maranhão PA, et al. Organ dysfunction in cirrhosis: a mechanism involving the microcirculation. Eur J Gastroenterol Hepatol. 2019;31(5):618-625.
Albillos A, Rossi I, Cacho G, et al. Enhanced endothelium-dependent vasodilation in patients with cirrhosis. Am J Physiol. 1995;268(3 pt 1):G459-G464.
Jiron MI, Lee SS, Cerini R, Pugliese D, Hadengue A, Lebrec D. Effects of nitroglycerin on forearm haemodynamics in patients with cirrhosis. Clin Sci (Lond). 1988;74(4):433-436.
Ryan J, Jennings G, Dudley F, Chin-Dusting J. Smooth muscle-derived nitric oxide is elevated in isolated forearm veins in human alcoholic cirrhosis. Clin Sci (Lond). 1996;91(1):23-28.
Doi J, Shiraishi K, Haida M, Matsuzaki S. Abnormality of energy metabolism in the skeletal muscle of patients with liver cirrhosis and changes under administration of glucose and branched-chain amino acids. Tokai J Exp Clin Med. 2004;29(4):191-198.
Brito-Azevedo A, de Mello Perez R, Coelho HSM, et al. Propranolol improves endothelial dysfunction in advanced cirrhosis: the “endothelial exhaustion” hypothesis. Gut. 2016;65(8):1391-1392.
Battaglia S, Angus P, Chin-Dusting JPF. Role of the endothelium on vasoactive agents in patients with liver cirrhosis. J Gastroenterol Hepatol. 2006;21(7):1189-1193.
Helmy A, Ferguson JW, Hayes PC, Newby DE, Webb DJ. Bradykinin does not contribute to peripheral vascular tone in patients with cirrhosis and ascites. J Cardiovasc Pharmacol. 2006;47(4):556-560.
Vaughan RB, Angus PW, Chin-Dusting JPF. Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation. Gut. 2003;52(10):1505-1510.
Helmy A, Newby DE, Jalan R, Hayes PC, Webb DJ. Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide. Gut. 2003;52(3):410-415.
Helmy A, Jalan R, Newby DE, Johnston NR, Hayes PC, Webb DJ. Altered peripheral vascular responses to exogenous and endogenous endothelin-1 in patients with well-compensated cirrhosis. Hepatology. 2001;33(4):826-831.
Chin-Dusting JP, Rasaratnam B, Jennings GL, Dudley FJ. Effect of fluoroquinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis. Ann Intern Med. 1997;127(11):985-988.
Cífková R, Pit'ha J, Trunecuka P, et al. Blood pressure, endothelial function and circulating endothelin concentrations in liver transplant recipients. J Hypertens. 2001;19(8):1359-1367.
Angeloni L, Berzigotti A, Bianchi G, Ramilli S, Magalotti D, Zoli M. Systemic Endothelial Function Evaluated by Flow-Mediated Dilatation of Brachial Artery in Patients with Liver Cirrhosis. J Hepatol; 2005:64.
Marcacci M, Fiorni M, Lattanzi A, et al. 215 is flow-mediated dilatation (FMD) assessment a reliable marker of endothelial dysfunction in liver cirrhosis? J Hepatol. 2013;58:S93.
Sárközi A, Cseh D, Gerlei Z, Kollai M. Reduced neural baroreflex sensitivity is related to enhanced endothelial function in patients with end-stage liver disease. Scand J Gastroenterol. 2018;53(2):193-199.
Seino Y, Ohki K, Nakamura T, et al. Pathophysiological characteristics of cutaneous microcirculation in patients with liver cirrhosis: relationships to cardiovascular hemodynamics and plasma neurohormonal factors. Microvasc Res. 1993;46(2):206-215.
Aird WC. Phenotypic heterogeneity of the endothelium. Circ Res. 2007;100(2):158-173.
Flammer AJ, Anderson T, Celermajer DS, et al. The assessment of endothelial function: from research into clinical practice. Circulation. 2012;126(6):753-767.
Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol. 2004;15(8):1983-1992.
Bosch J, Abraldes JG, Fernández M, García-Pagán JC. Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. J Hepatol. 2010;53(3):558-567.
Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough: the paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology. 2002;35(2):478-491.
Keeling AN, Flaherty JD, Davarpanah AH, et al. Coronary multidetector computed tomographic angiography to evaluate coronary artery disease in liver transplant candidates: methods, feasibility and initial experience. J Cardiovasc Med (Hagerstown). 2011;12(7):460-468.
McAvoy NC, Kochar N, McKillop G, Newby DE, Hayes PC. Prevalence of coronary artery calcification in patients undergoing assessment for orthotopic liver transplantation. Liver Transpl. 2008;14(12):1725-1731.
Tiukinhoy-Laing SD, Rossi JS, Bayram M, et al. Cardiac hemodynamic and coronary angiographic characteristics of patients being evaluated for liver transplantation. Am J Cardiol. 2006;98(2):178-181.
Carrier P, Debette-Gratien M, Jacques J, Loustaud-Ratti V. Cirrhotic patients and older people. World J Hepatol. 2019;11(9):663-677.
Kanwal F, Tansel A, Kramer JR, Feng H, Asch SM, El-Serag HB. Trends in 30-day and 1-year mortality among patients hospitalized with cirrhosis from 2004 to 2013. Am J Gastroenterol. 2017;112(8):1287-1297.
Schmidt ML, Barritt AS, Orman ES, Hayashi PH. Decreasing mortality among patients hospitalized with cirrhosis in the United States from 2002 through 2010. Gastroenterology. 2015;148(5):967-977.e2.
Moon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol. 2020;18(12):2650-2666.
Papatheodoridis GV, Sypsa V, Dalekos G, et al. Eight-year survival in chronic hepatitis B patients under long-term entecavir or tenofovir therapy is similar to the general population. J Hepatol. 2018;68(6):1129-1136.
Fede G, Privitera G, Tomaselli T, Spadaro L, Purrello F. Cardiovascular dysfunction in patients with liver cirrhosis. Ann Gastroenterol. 2015;28(1):31-40.
European Association for the Study of the liver (EASL), European Association for the Study of diabetes (EASD), European Association for the Study of obesity (EASO). EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):1388-1402.
Younossi Z, Anstee QM, Marietti M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15(1):11-20.
Adam R, Karam V, Cailliez V, et al. 2018 annual report of the European liver transplant registry (ELTR)-50-year evolution of liver transplantation. Transpl Int. 2018;31(12):1293-1317.
Khandelwal R, Dassanayake AS, Conjeevaram HS, Singh SP. Non-alcoholic fatty liver disease in diabetes: when to refer to the hepatologist? World J Diabetes. 2021;12(9):1479-1493.
Edens MA, Kuipers F, Stolk RP. Non-alcoholic fatty liver disease is associated with cardiovascular disease risk markers. Obes Rev. 2009;10(4):412-419.
Targher G, Arcaro G. Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis. 2007;191(2):235-240.
Hamaguchi M, Kojima T, Takeda N, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol. 2007;13(10):1579-1584.
Hadi HA, Carr CS, Al SJ. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag. 2005;1(3):183-198.
Shechter M, Issachar A, Marai I, et al. Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease. Int J Cardiol. 2009;134(1):52-58.
Anderson TJ, Charbonneau F, Title LM, et al. Microvascular function predicts cardiovascular events in primary prevention: long-term results from the firefighters and their endothelium (FATE) study. Circulation. 2011;123(2):163-169.
Higgins J, Thomas J, Chandler J, et al. Cochrane Handbook for Systematic Reviews of Interventions [Internet]. 2nd ed. John Wiley & Sons; 2019 Available from: https://training.cochrane.org/handbook/current