A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs.

Breast Neoplasms / genetics Female Humans Phosphoproteins RNA, Messenger / genetics RNA, Transfer / metabolism RNA-Binding Proteins / genetics Ribonucleoproteins / genetics Nucleolin
Mthfd1l Pafah1b1 breast cancer metastasis nucleolin oligomerization post-transcriptional tRF tRNA fragment transcript stability

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
21 07 2022
Historique:
received: 15 06 2021
revised: 04 04 2022
accepted: 05 05 2022
pubmed: 3 6 2022
medline: 27 7 2022
entrez: 2 6 2022
Statut: ppublish

Résumé

Stress-induced cleavage of transfer RNAs (tRNAs) into tRNA-derived fragments (tRFs) occurs across organisms from yeast to humans; yet, its mechanistic underpinnings and pathological consequences remain poorly defined. Small RNA profiling revealed increased abundance of a cysteine tRNA fragment (5'-tRF

Identifiants

DOI: 10.1016/j.molcel.2022.05.008 PMID: 35654044 PMC: PMC9444141
pubmed: 35654044
pii: S1097-2765(22)00442-7
doi: 10.1016/j.molcel.2022.05.008
pmc: PMC9444141
mid: NIHMS1827300
pii:
doi:

Substances chimiques

Phosphoproteins 0
RNA, Messenger 0
RNA-Binding Proteins 0
Ribonucleoproteins 0
RNA, Transfer 9014-25-9

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2604-2617.e8

Subventions

Organisme : NCI NIH HHS
ID : U54 CA261701
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA247026
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215491
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.F.T. is a cofounder, shareholder, and member of the scientific advisory board of Inspirna.

Références

Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
J Biochem. 2002 May;131(5):635-40
pubmed: 11983068
Cell. 2015 May 7;161(4):790-802
pubmed: 25957686
FEBS Lett. 2009 Jan 22;583(2):437-42
pubmed: 19114040
Cell. 2018 Jul 12;174(2):391-405.e19
pubmed: 29937225
Nat Med. 2011 Oct 23;17(11):1514-20
pubmed: 22019887
Nature. 2020 Oct;586(7828):299-304
pubmed: 32999457
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Bioinformatics. 2017 Feb 15;33(4):566-567
pubmed: 27797762
Nat Rev Cancer. 2017 Apr 24;17(5):332
pubmed: 28436470
BMC Mol Biol. 2007 Aug 10;8:66
pubmed: 17692122
Science. 2012 May 25;336(6084):1040-4
pubmed: 22628656
J Biol Chem. 2004 Mar 19;279(12):10855-63
pubmed: 14679209
Science. 2016 Jan 22;351(6271):397-400
pubmed: 26721680
Nature. 2005 Jul 28;436(7050):518-24
pubmed: 16049480
Nature. 2015 May 14;521(7551):232-6
pubmed: 25915022
Virus Res. 2001 Jul;76(1):17-29
pubmed: 11376843
Genome Res. 2013 Jun;23(6):977-87
pubmed: 23580730
J Biol Chem. 2011 Dec 23;286(51):44095-44103
pubmed: 22049078
Mol Cell. 2012 May 25;46(4):507-17
pubmed: 22503104
Genes (Basel). 2018 Dec 05;9(12):
pubmed: 30563140
Genome Biol. 2014;15(12):550
pubmed: 25516281
Cell. 1989 Oct 6;59(1):207-18
pubmed: 2477156
Transl Oncol. 2019 Nov;12(11):1416-1424
pubmed: 31401334
Science. 2016 Jan 22;351(6271):391-396
pubmed: 26721685
J Mol Biol. 1996 Jul 5;260(1):34-53
pubmed: 8676391
Enzymes. 2015;38:1-22
pubmed: 26612643
Nat Protoc. 2014 Feb;9(2):263-93
pubmed: 24407355
Nature. 2017 Dec 7;552(7683):57-62
pubmed: 29186115
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
Cell Metab. 2016 Oct 11;24(4):640-641
pubmed: 27732838
Cell. 2017 Jun 29;170(1):61-71.e11
pubmed: 28666125
Nucleic Acids Res. 2020 Aug 20;48(14):8035-8049
pubmed: 32609822
J Biol Chem. 1998 May 29;273(22):14002-7
pubmed: 9593750
Methods. 2017 Aug 15;126:112-129
pubmed: 28579404
Cancer Res. 2014 Mar 1;74(5):1463-74
pubmed: 24425047
RNA. 2004 Oct;10(10):1518-25
pubmed: 15337849
Nat Methods. 2012 Mar 04;9(4):403-9
pubmed: 22388288
Cell. 2011 Sep 30;147(1):81-94
pubmed: 21962509
Nucleic Acids Res. 2009 Jan;37(Database issue):D93-7
pubmed: 18984615
Cell. 2018 Sep 20;175(1):117-132.e21
pubmed: 30197082
RNA. 2017 Nov;23(11):1660-1671
pubmed: 28808124
EMBO J. 1999 Sep 1;18(17):4865-74
pubmed: 10469664
Cancer Res. 2011 May 1;71(9):3236-45
pubmed: 21415164
Cell. 2012 Mar 16;148(6):1172-87
pubmed: 22424228
Nat Chem Biol. 2020 Dec;16(12):1351-1360
pubmed: 32778843
Mol Cell. 2011 Aug 19;43(4):613-23
pubmed: 21855800
Nat Genet. 2014 Mar;46(3):245-52
pubmed: 24487275
RNA Biol. 2012 Jun;9(6):799-808
pubmed: 22617883
Cancer Res. 1978 Oct;38(10):3174-81
pubmed: 210930
Cell. 2017 Jul 13;170(2):352-366.e13
pubmed: 28709002
Bioinformatics. 2012 Dec 1;28(23):3013-20
pubmed: 23024010
Mol Cell. 2018 Feb 15;69(4):610-621.e5
pubmed: 29452640
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9667-72
pubmed: 17535905
J Biol Chem. 2012 Aug 24;287(35):29516-28
pubmed: 22761433
Cell. 2015 Jan 29;160(3):393-406
pubmed: 25601461
J Biol Chem. 1995 Jul 21;270(29):17292-8
pubmed: 7615529
J Biol Chem. 2000 Jun 23;275(25):18845-50
pubmed: 10858445
Nat Rev Cancer. 2013 Aug;13(8):572-83
pubmed: 23822983
Nucleic Acids Res. 2011 Oct;39(19):8513-30
pubmed: 21737422
EMBO J. 1998 Mar 2;17(5):1476-86
pubmed: 9482744
Cancer Discov. 2012 Oct;2(10):881-98
pubmed: 23009760
J Biol Chem. 2012 May 11;287(20):16467-76
pubmed: 22433872
Biochem Biophys Res Commun. 2018 Jun 27;501(3):654-660
pubmed: 29758199
Nat Rev Cancer. 2016 Oct;16(10):650-62
pubmed: 27634448
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Trends Cell Biol. 2007 Feb;17(2):80-6
pubmed: 17157503
Chem Biol. 2014 Jul 17;21(7):831-40
pubmed: 24954006
Cell. 2012 Nov 21;151(5):1068-82
pubmed: 23142051
Cell Rep. 2020 Dec 22;33(12):108527
pubmed: 33357439
Lung Cancer. 2012 Sep;77(3):585-92
pubmed: 22749159
Biochimie. 1996;78(6):530-8
pubmed: 8915542
Mass Spectrom Rev. 2020 May;39(3):229-244
pubmed: 28691345
Transl Oncol. 2019 Nov;12(11):1461-1467
pubmed: 31421459
Nucleic Acids Res. 2016 Jan 4;44(D1):D184-9
pubmed: 26673694
Cell. 2005 Oct 7;123(1):49-63
pubmed: 16213212
Chem Biol Drug Des. 2017 Nov;90(5):730-738
pubmed: 28378898
Cell Metab. 2017 Jan 10;25(1):27-42
pubmed: 27641100
Nat Rev Mol Cell Biol. 2018 Jan;19(1):45-58
pubmed: 28875994
Cell. 2018 Nov 29;175(6):1546-1560.e17
pubmed: 30500537
J Cell Biol. 2009 Apr 6;185(1):35-42
pubmed: 19332886
Nat Commun. 2013;4:2612
pubmed: 24113773
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3816-25
pubmed: 26124144
J Cell Sci. 1999 Mar;112 ( Pt 6):761-72
pubmed: 10036227
RNA. 2009 Dec;15(12):2147-60
pubmed: 19850906
Cancer Res. 1992 Mar 15;52(6):1399-405
pubmed: 1540948
Nucleic Acids Res. 2018 Jan 4;46(D1):D152-D159
pubmed: 29186503
Nucleic Acids Res. 2009 Apr;37(6):e43
pubmed: 19223327
J Clin Invest. 2017 May 1;127(5):1856-1872
pubmed: 28394261
Mol Cell. 2014 Sep 18;55(6):868-879
pubmed: 25175028
J Exp Med. 2013 May 6;210(5):951-68
pubmed: 23610125
Genes Dev. 2009 Nov 15;23(22):2639-49
pubmed: 19933153
FASEB J. 1999 Nov;13(14):1911-22
pubmed: 10544174
Sci Adv. 2016 May 27;2(5):e1600200
pubmed: 27386546
Genes Dev. 2008 Oct 15;22(20):2773-85
pubmed: 18923076
Crit Rev Biochem Mol Biol. 2013 Jan-Feb;48(1):20-38
pubmed: 23350810

Auteurs

Xuhang Liu (X)

Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA.

Wenbin Mei (W)

Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA.

Veena Padmanaban (V)

Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA.

Hanan Alwaseem (H)

Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.

Henrik Molina (H)

Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.

Maria C Passarelli (MC)

Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA.

Bernardo Tavora (B)

Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA.

Sohail F Tavazoie (SF)

Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: sohail.tavazoie@rockefeller.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › A pro-metastatic tRNA fragment drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A pro-metastatic tRNA fragment drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › A pro-metastatic tRNA fragment drives...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › A pro-metastatic tRNA fragment drives...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN de transfert › A pro-metastatic tRNA fragment drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › A pro-metastatic tRNA fragment drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › A pro-metastatic tRNA fragment drives...