Multiomics analysis of the NAD

ADP-Ribosylation Animals Embryonic Stem Cells / metabolism Mice NAD / metabolism Poly (ADP-Ribose) Polymerase-1 / genetics Poly(ADP-ribose) Polymerases / genetics Proteomics
ADP-ribosylation NAD+ biosynthesis PARP1 Preiss–Handler pathway U2AF35 U2AF65 de novo pathway embryonic stem cells (ESCs) metabolomics nicotinamide adenine dinucleotide (NAD+) proteomics salvage pathway spliceosome splicing

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 05 2022
Historique:
received: 23 12 2021
accepted: 16 05 2022
pubmed: 3 6 2022
medline: 14 6 2022
entrez: 2 6 2022
Statut: ppublish

Résumé

The differentiation of embryonic stem cells (ESCs) into a lineage-committed state is a dynamic process involving changes in cellular metabolism, epigenetic modifications, post-translational modifications, gene expression, and RNA processing. Here we integrated data from metabolomic, proteomic, and transcriptomic assays to characterize how alterations in NAD

Identifiants

DOI: 10.1101/gad.349335.121 PMID: 35654456 PMC: PMC9186393
pubmed: 35654456
pii: gad.349335.121
doi: 10.1101/gad.349335.121
pmc: PMC9186393
doi:

Substances chimiques

NAD 0U46U6E8UK
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30
Poly(ADP-ribose) Polymerases EC 2.4.2.30

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

601-617

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK069710
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK058110
Pays : United States

Informations de copyright

© 2022 Jones and Kraus; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Aarin Jones (A)

The Laboratory of Signaling and Gene Expression, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
The Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Program in Genetics, Development, and Disease, Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

W Lee Kraus (WL)

The Laboratory of Signaling and Gene Expression, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
The Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Program in Genetics, Development, and Disease, Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
ORCID: 0000-0002-8786-2986

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › ADP-Ribosylation › Multiomics analysis of the NAD
questionsmedicales.fr › Eucaryotes › Animaux › Multiomics analysis of the NAD
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Multiomics analysis of the NAD
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Multiomics analysis of the NAD
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Multiomics analysis of the NAD
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Poly (ADP-Ribose) polymerase-1 › Multiomics analysis of the NAD
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Multiomics analysis of the NAD
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Multiomics analysis of the NAD