A multiscale X-ray phase-contrast tomography dataset of a whole human left lung.

Humans Lung / diagnostic imaging Microscopy, Phase-Contrast Synchrotrons Tomography, X-Ray Computed

Journal

Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192

Informations de publication

Date de publication:
02 06 2022
Historique:
received: 01 12 2021
accepted: 03 05 2022
entrez: 2 6 2022
pubmed: 3 6 2022
medline: 7 6 2022
Statut: epublish

Résumé

Technological advancements in X-ray imaging using bright and coherent synchrotron sources now allows the decoupling of sample size and resolution while maintaining high sensitivity to the microstructures of soft, partially dehydrated tissues. The continuous developments in multiscale X-ray imaging resulted in hierarchical phase-contrast tomography, a comprehensive approach to address the challenge of organ-scale (up to tens of centimeters) soft tissue imaging with resolution and sensitivity down to the cellular level. Using this technique, we imaged ex vivo an entire human left lung at an isotropic voxel size of 25.08 μm along with local zooms down to 6.05-6.5 μm and 2.45-2.5 μm in voxel size. The high tissue contrast offered by the fourth-generation synchrotron source at the European Synchrotron Radiation Facility reveals the complex multiscale anatomical constitution of the human lung from the macroscopic (centimeter) down to the microscopic (micrometer) scale. The dataset provides comprehensive organ-scale 3D information of the secondary pulmonary lobules and delineates the microstructure of lung nodules with unprecedented detail.

Identifiants

DOI: 10.1038/s41597-022-01353-y PMID: 35654864 PMC: PMC9163096
pubmed: 35654864
doi: 10.1038/s41597-022-01353-y
pii: 10.1038/s41597-022-01353-y
pmc: PMC9163096
doi:

Types de publication

Dataset Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

264

Subventions

Organisme : Medical Research Council
ID : MR/S007687/1
Pays : United Kingdom
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : HL94567
Organisme : Royal Academy of Engineering
ID : PDL - CiET1819/10
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/R025673/1
Organisme : Wellcome Trust (Wellcome)
ID : 209553/Z/17/Z
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : HL134229

Informations de copyright

© 2022. The Author(s).

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Auteurs

R Patrick Xian (RP)

Department of Mechanical Engineering, University College London, London, UK. rp.xian@ucl.ac.uk.

Claire L Walsh (CL)

Department of Mechanical Engineering, University College London, London, UK.

Stijn E Verleden (SE)

Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), University of Antwerp, Wilrijk, Belgium.

Willi L Wagner (WL)

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Translational Lung Research Centre Heidelberg (TLRC), German Lung Research Centre (DZL), Heidelberg, Germany.

Alexandre Bellier (A)

Laboratoire d'Anatomie des Alpes Françaises (LADAF), Université Grenoble Alpes, Grenoble, France.

Sebastian Marussi (S)

Department of Mechanical Engineering, University College London, London, UK.

Maximilian Ackermann (M)

Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Danny D Jonigk (DD)

Institute of Pathology, Hannover Medical School, Hannover, Germany.
Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), German Lung Research Centre (DZL), Hannover, Germany.
ORCID: 0000-0002-5251-2281

Joseph Jacob (J)

Centre for Medical Image Computing, University College London, London, UK.
Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK.

Peter D Lee (PD)

Department of Mechanical Engineering, University College London, London, UK. peter.lee@ucl.ac.uk.
ORCID: 0000-0002-3898-8881

Paul Tafforeau (P)

European Synchrotron Radiation Facility, Grenoble, France. paul.tafforeau@esrf.fr.
ORCID: 0000-0002-5962-1683

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A multiscale X-ray phase-contrast tomography...
questionsmedicales.fr › Appareil respiratoire › Poumon › A multiscale X-ray phase-contrast tomography...
questionsmedicales.fr › Techniques d'investigation › Microscopie interférentielle › Microscopie de contraste de phase › A multiscale X-ray phase-contrast tomography...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Accélérateurs de particules › Synchrotrons › A multiscale X-ray phase-contrast tomography...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › A multiscale X-ray phase-contrast tomography...