Synchrony and idiosyncrasy in the gut microbiome of wild baboons.
Journal
Nature ecology & evolution
ISSN: 2397-334X
Titre abrégé: Nat Ecol Evol
Pays: England
ID NLM: 101698577
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
18
11
2021
accepted:
20
04
2022
pubmed:
3
6
2022
medline:
12
7
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
Human gut microbial dynamics are highly individualized, making it challenging to link microbiota to health and to design universal microbiome therapies. This individuality is typically attributed to variation in host genetics, diets, environments and medications but it could also emerge from fundamental ecological forces that shape microbiota more generally. Here, we leverage extensive gut microbial time series from wild baboons-hosts who experience little interindividual dietary and environmental heterogeneity-to test whether gut microbial dynamics are synchronized across hosts or largely idiosyncratic. Despite their shared lifestyles, baboon microbiota were only weakly synchronized. The strongest synchrony occurred among baboons living in the same social group, probably because group members range over the same habitat and simultaneously encounter the same sources of food and water. However, this synchrony was modest compared to each host's personalized dynamics. In support, host-specific factors, especially host identity, explained, on average, more than three times the deviance in longitudinal dynamics compared to factors shared with social group members and ten times the deviance of factors shared across the host population. These results contribute to mounting evidence that highly idiosyncratic gut microbiomes are not an artefact of modern human environments and that synchronizing forces in the gut microbiome (for example, shared environments, diets and microbial dispersal) are not strong enough to overwhelm key drivers of microbiome personalization, such as host genetics, priority effects, horizontal gene transfer and functional redundancy.
Identifiants
pubmed: 35654895
doi: 10.1038/s41559-022-01773-4
pii: 10.1038/s41559-022-01773-4
pmc: PMC9271586
mid: NIHMS1800392
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
955-964Subventions
Organisme : NIA NIH HHS
ID : R01 AG053330
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128716
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG071684
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG055777
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD065563
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031719
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG049936
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG045459
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG034513
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD088558
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024361
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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