Transferability of genetic risk scores in African populations.

Black People / genetics Cholesterol, LDL / genetics Genome-Wide Association Study Humans Population Groups Risk Factors

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
06 2022
Historique:
received: 18 08 2021
accepted: 20 04 2022
pubmed: 3 6 2022
medline: 22 6 2022
entrez: 2 6 2022
Statut: ppublish

Résumé

The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out to evaluate whether GRSs derived from data of African American individuals and multiancestry data perform better in sub-Saharan Africa (SSA) compared to European ancestry-derived scores. Using summary statistics from the Million Veteran Program (MVP), we showed that GRSs derived from data of African American individuals enhance polygenic prediction of lipid traits in SSA compared to European and multiancestry scores. However, our GRS prediction varied greatly within SSA between the South African Zulu (low-density lipoprotein cholesterol (LDL-C), R

Identifiants

DOI: 10.1038/s41591-022-01835-x PMID: 35654908 PMC: PMC9205766
pubmed: 35654908
doi: 10.1038/s41591-022-01835-x
pii: 10.1038/s41591-022-01835-x
pmc: PMC9205766
doi:

Substances chimiques

Cholesterol, LDL 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1163-1166

Subventions

Organisme : Medical Research Council
ID : MRC-RFA-SHIP01/2015
Pays : United Kingdom
Organisme : Department of Health
ID : CL-2020-1.0.6-001
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG011717
Pays : United States
Organisme : Wellcome Trust
ID : 214205/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220740/Z/20/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1204/16
Pays : United Kingdom
Organisme : FIC NIH HHS
ID : U2R TW010673
Pays : United States
Organisme : British Heart Foundation
ID : RE/18/4/34215
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Abram B Kamiza (AB)

The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.
Malawi Epidemiology and Intervention Research Unit, Lilongwe, Karonga, Malawi.
Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Sounkou M Toure (SM)

The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.
African Centre of Excellence in Bioinformatics, University of Science and Technologies of Bamako, Bamako, Mali.

Marijana Vujkovic (M)

Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada.
ORCID: 0000-0003-4924-5714

Tafadzwa Machipisa (T)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Hatter Institute for Cardiovascular Diseases Research in Africa (HICRA), Department of Medicine, University of Cape Town, Cape Town, South Africa.
Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
ORCID: 0000-0002-4882-9067

Opeyemi S Soremekun (OS)

The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.

Christopher Kintu (C)

The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.

Manuel Corpas (M)

Cambridge Precision Medicine Limited, ideaSpace, University of Cambridge Biomedical Innovation Hub, Cambridge, United Kingdom.
Institute of Continuing Education, Madingley Hall, University of Cambridge, Cambridge, UK.
Facultad de Ciencias de la Salud, Universidade Internacional de La Rioja, Madrid, Spain.
ORCID: 0000-0002-4417-1018

Fraser Pirie (F)

Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa.

Elizabeth Young (E)

Omnigen Biodata Ltd, Cambridge, UK.

Dipender Gill (D)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St George's, University of London, London, UK.
ORCID: 0000-0001-7312-7078

Manjinder S Sandhu (MS)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

Pontiano Kaleebu (P)

MRC/UVRI and LSHTM, Entebbe, Uganda.

Moffat Nyirenda (M)

MRC/UVRI and LSHTM, Entebbe, Uganda.
ORCID: 0000-0003-2120-4806

Ayesha A Motala (AA)

Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa.

Tinashe Chikowore (T)

Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. tinashe.chikowore1@wits.ac.za.
MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. tinashe.chikowore1@wits.ac.za.
ORCID: 0000-0002-6743-751X

Segun Fatumo (S)

The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda. segun.fatumo@lshtm.ac.uk.
MRC/UVRI and LSHTM, Entebbe, Uganda. segun.fatumo@lshtm.ac.uk.
London School of Hygiene and Tropical Medicine, London, UK. segun.fatumo@lshtm.ac.uk.
H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria. segun.fatumo@lshtm.ac.uk.
ORCID: 0000-0003-4525-3362

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Classifications MeSH

questionsmedicales.fr › Personnes › Noirs › Transferability of genetic risk scores in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Transferability of genetic risk scores in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Transferability of genetic risk scores in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transferability of genetic risk scores in...
questionsmedicales.fr › Caractéristiques de la population › Groupes de population › Transferability of genetic risk scores in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Transferability of genetic risk scores in...