A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

Alanine Transaminase Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics Genome-Wide Association Study Humans Intracellular Signaling Peptides and Proteins / genetics Lipase / genetics Membrane Proteins / genetics Non-alcoholic Fatty Liver Disease / genetics Polymorphism, Single Nucleotide / genetics Protein Serine-Threonine Kinases / antagonists & inhibitors

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
06 2022
Historique:
received: 18 12 2020
accepted: 18 04 2022
pubmed: 3 6 2022
medline: 18 6 2022
entrez: 2 6 2022
Statut: ppublish

Résumé

Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P < 5 × 10

Identifiants

DOI: 10.1038/s41588-022-01078-z PMID: 35654975 PMC: PMC10024253
pubmed: 35654975
doi: 10.1038/s41588-022-01078-z
pii: 10.1038/s41588-022-01078-z
pmc: PMC10024253
mid: NIHMS1862002
doi:

Substances chimiques

Intracellular Signaling Peptides and Proteins 0
Membrane Proteins 0
TRIB1 protein, human 0
Alpha-Ketoglutarate-Dependent Dioxygenase FTO EC 1.14.11.33
FTO protein, human EC 1.14.11.33
Alanine Transaminase EC 2.6.1.2
Protein Serine-Threonine Kinases EC 2.7.11.1
Lipase EC 3.1.1.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

761-771

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL137984
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111024
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061732
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB029460
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK115897
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127083
Pays : United States
Organisme : BLRD VA
ID : I01 BX003362
Pays : United States
Organisme : BLRD VA
ID : I01 BX003341
Pays : United States
Organisme : NHGRI NIH HHS
ID : K08 HG010155
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026302
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK126194
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123539
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK098246
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001878
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI133172
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK099716
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114291
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134853
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG011719
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM010685
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101478
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD056465
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK061730
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK124577
Pays : United States
Organisme : CSRD VA
ID : I01 CX001737
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061738
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK078616
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002378
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122586
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK113252
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151855
Pays : United States
Organisme : BLRD VA
ID : I01 BX005831
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK078616
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI156161
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007734
Pays : United States

Informations de copyright

© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

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Auteurs

Marijana Vujkovic (M)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0003-4924-5714

Shweta Ramdas (S)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Kim M Lorenz (KM)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0001-8674-2942

Xiuqing Guo (X)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0002-5264-5068

Rebecca Darlay (R)

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Heather J Cordell (HJ)

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
ORCID: 0000-0002-1879-5572

Jing He (J)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Yevgeniy Gindin (Y)

Gilead Sciences, Inc., Foster City, CA, USA.

Chuhan Chung (C)

Gilead Sciences, Inc., Foster City, CA, USA.

Robert P Myers (RP)

Gilead Sciences, Inc., Foster City, CA, USA.
The Liver Company, Palo Alto, CA, USA.

Carolin V Schneider (CV)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Joseph Park (J)

Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-3313-641X

Kyung Min Lee (KM)

VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
ORCID: 0000-0001-8995-0448

Marina Serper (M)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Rotonya M Carr (RM)

Division of Gastroenterology, University of Washington, Seattle, WA, USA.

David E Kaplan (DE)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-3839-336X

Mary E Haas (ME)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Matthew T MacLean (MT)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Walter R Witschey (WR)

Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0003-1669-2120

Xiang Zhu (X)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Statistics, The Pennsylvania State University, University Park, PA, USA.
Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.
Department of Statistics, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-1134-6413

Catherine Tcheandjieu (C)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0001-9559-4339

Rachel L Kember (RL)

Mental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0001-8820-2659

Henry R Kranzler (HR)

Mental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-1018-0450

Anurag Verma (A)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Ayush Giri (A)

Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-7786-4670

Derek M Klarin (DM)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Division of Vascular Surgery, Stanford University School of Medicine, Palo Alto, CA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-4636-5780

Yan V Sun (YV)

Atlanta VA Medical Center, Decatur, GA, USA.
Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
ORCID: 0000-0002-2838-1824

Jie Huang (J)

School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.
ORCID: 0000-0002-9036-4304

Jennifer E Huffman (JE)

VA Boston Healthcare System, Boston, MA, USA.
ORCID: 0000-0002-9672-2491

Kate Townsend Creasy (KT)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0003-1870-4586

Nicholas J Hand (NJ)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-8172-1816

Ching-Ti Liu (CT)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0002-0703-0742

Michelle T Long (MT)

Department of Medicine, Section of Gastroenterology, Boston University School of Medicine, Boston, MA, USA.

Jie Yao (J)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Matthew Budoff (M)

Department of Cardiology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0002-9616-1946

Jingyi Tan (J)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Xiaohui Li (X)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Henry J Lin (HJ)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-6771-0486

Yii-Der Ida Chen (YI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Ruey-Kang Chang (RK)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Ronald M Krauss (RM)

Departments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA.

Silvia Vilarinho (S)

Section of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
ORCID: 0000-0002-2099-4212

Joseph Brancale (J)

Section of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

Jonas B Nielsen (JB)

Regeneron Genetics Center, Tarrytown, NY, USA.

Adam E Locke (AE)

Regeneron Genetics Center, Tarrytown, NY, USA.
ORCID: 0000-0001-6227-198X

Marcus B Jones (MB)

Regeneron Genetics Center, Tarrytown, NY, USA.

Niek Verweij (N)

Regeneron Genetics Center, Tarrytown, NY, USA.

Aris Baras (A)

Regeneron Genetics Center, Tarrytown, NY, USA.
ORCID: 0000-0002-6830-3396

K Rajender Reddy (KR)

Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Brent A Neuschwander-Tetri (BA)

Department of Internal Medicine, Saint Louis University, St. Louis, MO, USA.
ORCID: 0000-0002-8520-7398

Jeffrey B Schwimmer (JB)

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

Arun J Sanyal (AJ)

Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

Naga Chalasani (N)

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Kathleen A Ryan (KA)

Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0003-1158-8455

Braxton D Mitchell (BD)

Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Dipender Gill (D)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
ORCID: 0000-0001-7312-7078

Andrew D Wells (AD)

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Elisabetta Manduchi (E)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-4110-3714

Yedidya Saiman (Y)

Department of Medicine, Section of Hepatology, Lewis Katz School of Medicine at Temple University, Temple University Hospital, Philadelphia, PA, USA.

Nadim Mahmud (N)

Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Donald R Miller (DR)

Center for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA.
Center for Population Health, Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
ORCID: 0000-0002-7881-8801

Peter D Reaven (PD)

Phoenix VA Health Care System, Phoenix, AZ, USA.
College of Medicine, University of Arizona, Phoenix, AZ, USA.
ORCID: 0000-0001-8923-6690

Lawrence S Phillips (LS)

Atlanta VA Medical Center, Decatur, GA, USA.
Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA.
ORCID: 0000-0002-6542-8046

Sumitra Muralidhar (S)

Office of Research and Development, Veterans Health Administration, Washington, DC, USA.

Scott L DuVall (SL)

VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
ORCID: 0000-0002-4898-3865

Jennifer S Lee (JS)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Themistocles L Assimes (TL)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-2349-0009

Saiju Pyarajan (S)

VA Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Kelly Cho (K)

VA Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Todd L Edwards (TL)

Nashville VA Medical Center, Nashville, TN, USA.
Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0003-4318-6119

Scott M Damrauer (SM)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0001-8009-1632

Peter W Wilson (PW)

Atlanta VA Medical Center, Decatur, GA, USA.
Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.

J Michael Gaziano (JM)

VA Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.

Christopher J O'Donnell (CJ)

VA Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-2667-8624

Amit V Khera (AV)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0001-6535-5839

Struan F A Grant (SFA)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0003-2025-5302

Christopher D Brown (CD)

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Philip S Tsao (PS)

VA Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0001-7274-9318

Danish Saleheen (D)

Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.
Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.
ORCID: 0000-0001-6193-020X

Luca A Lotta (LA)

Regeneron Genetics Center, Tarrytown, NY, USA.

Lisa Bastarache (L)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Quentin M Anstee (QM)

Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Ann K Daly (AK)

Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

James B Meigs (JB)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Julie A Lynch (JA)

VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
College of Nursing and Health Sciences, University of Massachusetts, Lowell, MA, USA.
ORCID: 0000-0003-0108-2127

Daniel J Rader (DJ)

Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-9245-9876

Benjamin F Voight (BF)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.
Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.
ORCID: 0000-0002-6205-9994

Kyong-Mi Chang (KM)

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. kmchang@pennmedicine.upenn.edu.
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. kmchang@pennmedicine.upenn.edu.
ORCID: 0000-0001-6811-9364

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Alanine transaminase › A multiancestry genome-wide association study...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › Alpha-ketoglutarate-dependent dioxygenase FTO › A multiancestry genome-wide association study...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A multiancestry genome-wide association study...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A multiancestry genome-wide association study...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › A multiancestry genome-wide association study...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Triacylglycerol lipase › A multiancestry genome-wide association study...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › A multiancestry genome-wide association study...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › A multiancestry genome-wide association study...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › A multiancestry genome-wide association study...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › A multiancestry genome-wide association study...