Deep learning study of tyrosine reveals that roaming can lead to photodamage.


Journal

Nature chemistry
ISSN: 1755-4349
Titre abrégé: Nat Chem
Pays: England
ID NLM: 101499734

Informations de publication

Date de publication:
08 2022
Historique:
received: 13 09 2021
accepted: 13 04 2022
pubmed: 3 6 2022
medline: 11 8 2022
entrez: 2 6 2022
Statut: ppublish

Résumé

Amino acids are among the building blocks of life, forming peptides and proteins, and have been carefully 'selected' to prevent harmful reactions caused by light. To prevent photodamage, molecules relax from electronic excited states to the ground state faster than the harmful reactions can occur; however, such photochemistry is not fully understood, in part because theoretical simulations of such systems are extremely expensive-with only smaller chromophores accessible. Here, we study the excited-state dynamics of tyrosine using a method based on deep neural networks that leverages the physics underlying quantum chemical data and combines different levels of theory. We reveal unconventional and dynamically controlled 'roaming' dynamics in excited tyrosine that are beyond chemical intuition and compete with other ultrafast deactivation mechanisms. Our findings suggest that the roaming atoms are radicals that can lead to photodamage, offering a new perspective on the photostability and photodamage of biological systems.

Identifiants

pubmed: 35655007
doi: 10.1038/s41557-022-00950-z
pii: 10.1038/s41557-022-00950-z
doi:

Substances chimiques

Amino Acids 0
Tyrosine 42HK56048U

Banques de données

figshare
['10.6084/m9.figshare.15132081']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

914-919

Subventions

Organisme : Austrian Science Fund FWF
ID : J 4522
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : W 1232
Pays : Austria

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Julia Westermayr (J)

Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria.
Department of Chemistry, University of Warwick, Coventry, UK.

Michael Gastegger (M)

Machine Learning Group, Technical University of Berlin, Berlin, Germany.

Dóra Vörös (D)

Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria.

Lisa Panzenboeck (L)

Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria.
Faculty of Chemistry, Department of Analytical Chemistry, University of Vienna, Vienna, Austria.

Florian Joerg (F)

Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria.
Faculty of Chemistry, Institute of Computational Biological Chemistry, University of Vienna, Vienna, Austria.

Leticia González (L)

Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria.
Vienna Research Platform on Accelerating Photoreaction Discovery, University of Vienna, Vienna, Austria.

Philipp Marquetand (P)

Faculty of Chemistry, Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria. philipp.marquetand@univie.ac.at.
Vienna Research Platform on Accelerating Photoreaction Discovery, University of Vienna, Vienna, Austria. philipp.marquetand@univie.ac.at.
Research Network Data Science @ Uni Vienna, University of Vienna, Vienna, Austria. philipp.marquetand@univie.ac.at.

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