Defective mitophagy and the etiopathogenesis of Alzheimer's disease.

Alzheimer Disease / metabolism Humans Mitochondria / metabolism Mitophagy / physiology Neurons / metabolism
Alzheimer’s disease Aβ Mitophagy PINK1 Tau

Journal

Translational neurodegeneration
ISSN: 2047-9158
Titre abrégé: Transl Neurodegener
Pays: England
ID NLM: 101591861

Informations de publication

Date de publication:
03 06 2022
Historique:
received: 25 01 2022
accepted: 28 04 2022
entrez: 2 6 2022
pubmed: 3 6 2022
medline: 7 6 2022
Statut: epublish

Résumé

Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer's disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development. The interaction between mitophagy deficits and Aβ or Tau pathology may form a vicious cycle and cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD. Defective mitophagy is a potential target for AD prevention and treatment.

Identifiants

DOI: 10.1186/s40035-022-00305-1 PMID: 35655270 PMC: PMC9164340
pubmed: 35655270
doi: 10.1186/s40035-022-00305-1
pii: 10.1186/s40035-022-00305-1
pmc: PMC9164340
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

32

Informations de copyright

© 2022. The Author(s).

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Auteurs

Kuan Zeng (K)

Department of Psychiatry, Wuhan Mental Health Center, Wuhan, 430012, China.
Co-Innovation Center of Neurodegeneration, Nantong University, Nantong, 226001, China.
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wuhan Hospital for Psychotherapy, Wuhan, 430012, China.

Xuan Yu (X)

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Yacoubou Abdoul Razak Mahaman (YAR)

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Jian-Zhi Wang (JZ)

Co-Innovation Center of Neurodegeneration, Nantong University, Nantong, 226001, China.
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Rong Liu (R)

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Yi Li (Y)

Department of Psychiatry, Wuhan Mental Health Center, Wuhan, 430012, China. psylee@163.com.
Wuhan Hospital for Psychotherapy, Wuhan, 430012, China. psylee@163.com.

Xiaochuan Wang (X)

Co-Innovation Center of Neurodegeneration, Nantong University, Nantong, 226001, China. wxch@mails.tjmu.edu.cn.
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. wxch@mails.tjmu.edu.cn.
Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, 518000, China. wxch@mails.tjmu.edu.cn.
ORCID: 0000-0001-8207-0042

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Defective mitophagy and the etiopathogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Defective mitophagy and the etiopathogenesis...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Defective mitophagy and the etiopathogenesis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dégradation des mitochondries › Defective mitophagy and the etiopathogenesis...
questionsmedicales.fr › Cellules › Neurones › Defective mitophagy and the etiopathogenesis...