Diagnostic value of serum cystatin C for diabetic nephropathy: a meta-analysis.

Cystatin C Diabetes Mellitus Diabetic Nephropathies / diagnosis Humans Odds Ratio ROC Curve Sensitivity and Specificity
Cystatin C Diabetic nephropathy Diagnostic value Meta-analysis

Journal

BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676

Informations de publication

Date de publication:
02 Jun 2022
Historique:
received: 15 11 2020
accepted: 17 05 2022
entrez: 2 6 2022
pubmed: 3 6 2022
medline: 7 6 2022
Statut: epublish

Résumé

Although dozens of studies have investigated the relationship between the content of serum cystatin C (Cys-C) and diabetic nephropathy (DN), the results are still controversial. Hence, This study aims to explore the accuracy of serum Cys-C for diagnosing DN by meta-analysis. The studies about serum Cys-C diagnosing DN were searched from six online databases from inception to September 22, 2020. The data were processed by Stata 15.0 statistic software. The corresponding diagnostic effect sizes, such as sensitivity and specificity, were obtained. We drew a summary receiver operating characteristic (SROC) curve. We assess the risk of literature bias was following the QUADAS-2 guidelines. Twenty-six published studies were identified. The results showed a pooled sensitivity of 0.86 (95% confidence interval (CI): 0.82-0.90), specificity of 0.89 (95%CI: 0.85-0.92), positive likelihood ratio of 7.59 (95%CI: 5.66-10.19), negative likelihood ratio of 0.16 (95%CI: 0.12-0.21), and diagnostic odds ratio of 48.03 (95%CI: 30.64-75.29). The area under the SROC curve was given a value of 0.94 (95%CI: 0.91-0.96). Serum cystatin C has an excellent diagnostic value with good sensitivity and specificity for diabetic nephropathy.

Sections du résumé

BACKGROUND BACKGROUND
Although dozens of studies have investigated the relationship between the content of serum cystatin C (Cys-C) and diabetic nephropathy (DN), the results are still controversial. Hence, This study aims to explore the accuracy of serum Cys-C for diagnosing DN by meta-analysis.
METHODS METHODS
The studies about serum Cys-C diagnosing DN were searched from six online databases from inception to September 22, 2020. The data were processed by Stata 15.0 statistic software. The corresponding diagnostic effect sizes, such as sensitivity and specificity, were obtained. We drew a summary receiver operating characteristic (SROC) curve. We assess the risk of literature bias was following the QUADAS-2 guidelines.
RESULTS RESULTS
Twenty-six published studies were identified. The results showed a pooled sensitivity of 0.86 (95% confidence interval (CI): 0.82-0.90), specificity of 0.89 (95%CI: 0.85-0.92), positive likelihood ratio of 7.59 (95%CI: 5.66-10.19), negative likelihood ratio of 0.16 (95%CI: 0.12-0.21), and diagnostic odds ratio of 48.03 (95%CI: 30.64-75.29). The area under the SROC curve was given a value of 0.94 (95%CI: 0.91-0.96).
CONCLUSION CONCLUSIONS
Serum cystatin C has an excellent diagnostic value with good sensitivity and specificity for diabetic nephropathy.

Identifiants

DOI: 10.1186/s12902-022-01052-0 PMID: 35655297 PMC: PMC9164876
pubmed: 35655297
doi: 10.1186/s12902-022-01052-0
pii: 10.1186/s12902-022-01052-0
pmc: PMC9164876
doi:

Substances chimiques

Cystatin C 0

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

149

Informations de copyright

© 2022. The Author(s).

Références

Am J Kidney Dis. 2012 Nov;60(5):850-86
pubmed: 23067652
Scand J Clin Lab Invest. 2005;65(2):111-24
pubmed: 16025834
Am J Kidney Dis. 2013 Sep;62(3):595-603
pubmed: 23701892
Ann Intern Med. 2011 Oct 18;155(8):529-36
pubmed: 22007046
Diabetologia. 1993 Oct;36(10):1007-16
pubmed: 8243848
Pediatr Diabetes. 2020 Aug;21(5):846-855
pubmed: 32304131
J Intern Med. 2004 Dec;256(6):510-8
pubmed: 15554952
Diabetologia. 2011 Dec;54(12):2987-94
pubmed: 21947381
Diabetes Care. 2016 Jan;39 Suppl 1:S39-46
pubmed: 26696679
Diabetes Res Clin Pract. 2007 Dec;78(3):428-34
pubmed: 17822797
Diabetes Care. 2007 Aug;30(8):1988-94
pubmed: 17536079
Bosn J Basic Med Sci. 2005 Nov;5(4):68-71
pubmed: 16351602
Stat Med. 2009 Sep 20;28(21):2653-68
pubmed: 19591118
Diabetes Res Clin Pract. 2009 Feb;83(2):e58-61
pubmed: 19118914
Clin Chem. 2007 Mar;53(3):480-8
pubmed: 17259236
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Diabetes Metab. 2008 Nov;34(5):482-9
pubmed: 18703370
J Korean Med Sci. 2011 Feb;26(2):258-63
pubmed: 21286018
Clin Exp Med. 2016 Aug;16(3):437-42
pubmed: 26055459
J Investig Med. 2016 Aug;64(6):1102-8
pubmed: 27388615
J Med Screen. 2003;10(1):47-51
pubmed: 12790315
Endocr Metab Immune Disord Drug Targets. 2017;17(2):114-124
pubmed: 28699485
J Korean Med Sci. 2012 Jul;27(7):784-7
pubmed: 22787375
World J Mens Health. 2012 Dec;30(3):172-6
pubmed: 23596608
J Am Soc Nephrol. 2003 Jun;14(6):1480-6
pubmed: 12761248
Ther Apher Dial. 2016 Dec;20(6):579-587
pubmed: 27921376
Curr Opin Pharmacol. 2013 Aug;13(4):602-12
pubmed: 23721739
Clin Med Insights Endocrinol Diabetes. 2013 Jul 31;6:7-13
pubmed: 23966807
J Clin Epidemiol. 2005 Oct;58(10):982-90
pubmed: 16168343
N Engl J Med. 1985 Mar 7;312(10):617-21
pubmed: 3883162
N Engl J Med. 2012 Jul 5;367(1):20-9
pubmed: 22762315
Kidney Blood Press Res. 2016;41(6):919-928
pubmed: 27889768
Annu Rev Pathol. 2011;6:395-423
pubmed: 21261520
Expert Opin Pharmacother. 2011 Jan;12(1):47-62
pubmed: 21142694
Ann Thorac Surg. 2005 Jan;79(1):16-20
pubmed: 15620907
Am J Kidney Dis. 2001 Aug;38(2):310-6
pubmed: 11479157
Kidney Res Clin Pract. 2016 Jun;35(2):69-77
pubmed: 27366660
Contrib Nephrol. 2011;170:124-134
pubmed: 21659765
Ann Intern Med. 2003 Jul 15;139(2):137-47
pubmed: 12859163
Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E117-26
pubmed: 19887595
Nephron. 2002 May;91(1):13-20
pubmed: 12021514
Am J Kidney Dis. 2002 Aug;40(2):221-6
pubmed: 12148093
Clin Chem Lab Med. 2005;43(8):855-61
pubmed: 16201897
J Clin Epidemiol. 2003 Nov;56(11):1129-35
pubmed: 14615004
Scand J Clin Lab Invest. 2000 Oct;60(6):483-9
pubmed: 11129064
N Engl J Med. 2016 Sep 1;375(9):905-6
pubmed: 27579659
Stat Med. 2002 May 15;21(9):1237-56
pubmed: 12111876
Am J Kidney Dis. 2007 Feb;49(2 Suppl 2):S12-154
pubmed: 17276798
Am J Kidney Dis. 2014 Oct;64(4):510-33
pubmed: 25257325
Saudi J Kidney Dis Transpl. 2016 Jul-Aug;27(4):710-6
pubmed: 27424687
Exp Diabetes Res. 2012;2012:179849
pubmed: 23008697
Kidney Int. 2006 Jan;69(2):399-405
pubmed: 16408133
Stat Med. 2002 Feb 28;21(4):589-624
pubmed: 11836738
Diabet Med. 2007 Apr;24(4):443-8
pubmed: 17388960

Auteurs

Xueling Liao (X)

Department of Nephrology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, China.
Department of Nephrology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, China.

Yan Zhu (Y)

Department of Nephrology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, China.

Chao Xue (C)

Department of Nephrology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, China. xuechao@stu.gxmu.edu.cn.
ORCID: 0000-0002-4850-1029

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Cystatines › Cystatine C › Diagnostic value of serum cystatin C for...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diagnostic value of serum cystatin C for...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Néphropathies diabétiques › Diagnostic value of serum cystatin C for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diagnostic value of serum cystatin C for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Odds ratio › Diagnostic value of serum cystatin C for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Courbe ROC › Diagnostic value of serum cystatin C for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Diagnostic value of serum cystatin C for...