Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice.
Epitopes
HIV-1
Immunologic factors
Sleep deprivation
Spatial memory
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
22
10
2021
accepted:
19
01
2022
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
ppublish
Résumé
Sleep deprivation (SD) has a negative impact on cognitive functions including learning and memory. Many studies have shown that rapid-eye-movement (REM) SD also disrupts memory performance. In this study, we aimed to investigate the effect of multi-epitope Gag-Pol-Env-Tat derived from Human immunodeficiency virus 1 (HIV-1) on REM SD-induced spatial memory impairment with respect to the levels of interleukin-4 (IL-4), interleukin-17 (IL-17), interferon-gamma (IFN-γ), immunoglobulin G1 (IgG1), immunoglobulin G2a (IgG2a), and lymphocyte proliferation in NMRI mice. We used multi-epitope Gag-Pol-Env-Tat derived from HIV-1 because Gag-Pol-Env-Tat immunogen sequence is one of the most sensitive immunogen sequences of HIV-1 that can significantly augment cellular and humoral immune systems, leading to the improvement of cognitive functions. Morris water maze apparatus was used to assess spatial memory, and multi-platform apparatus was used to induce RSD for 24 hr. Multi-epitope derived from HIV-1 was subcutaneously injected at the dose of 20 µgr/ml, once and fourteen days before RSD. RSD impaired spatial memory and injection of multi-epitope derived from HIV-1 reversed this effect. RSD decreased IL-4, IgG1, and IgG2a levels, while multi-epitope derived from HIV-1 reversed these effects. Multi-epitope derived from HIV-1 also increased lymphocyte proliferation and decreased IL-17 levels in both control and RSD mice. Multi-epitope derived from HIV-1 may improve memory performance via induction of anti-inflammatory immune response.
Identifiants
pubmed: 35655593
doi: 10.22038/IJBMS.2022.61175.13536
pmc: PMC9124535
doi:
Types de publication
Journal Article
Langues
eng
Pagination
164-172Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
J Interferon Cytokine Res. 2009 Jul;29(7):393-8
pubmed: 19450150
Hippocampus. 2011 Aug;21(8):899-909
pubmed: 20865738
Brain Behav Immun. 2020 Jul;87:568-578
pubmed: 32032783
Mol Cell Neurosci. 2011 Apr;46(4):742-51
pubmed: 21338685
AIDS. 2019 Mar 15;33(4):627-636
pubmed: 30608274
J Exp Med. 2002 Mar 18;195(6):665-72
pubmed: 11901193
Nature. 2009 Oct 22;461(7267):1122-5
pubmed: 19847264
Pediatr Infect Dis J. 1990 Aug;9(8 Suppl):S16-24
pubmed: 2216603
EXCLI J. 2018 Sep 20;17:916-934
pubmed: 30564071
Reprod Biol Endocrinol. 2020 Jan 11;18(1):2
pubmed: 31926565
EXCLI J. 2021 Jun 04;20:1011-1027
pubmed: 34267613
Nat Rev Immunol. 2008 Feb;8(2):107-19
pubmed: 18219309
Neuroscience. 2020 May 1;433:200-211
pubmed: 32200080
Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov;393(11):2081-2091
pubmed: 32583046
Neuroimmunomodulation. 2006;13(5-6):357-74
pubmed: 17709958
J Int Neuropsychol Soc. 2018 Nov;24(10):1038-1046
pubmed: 30165914
Infect Immun. 1999 Jun;67(6):2713-9
pubmed: 10338473
Clin Diagn Lab Immunol. 2003 Mar;10(2):202-7
pubmed: 12626443
Aging (Albany NY). 2020 Aug 4;12(15):15281-15289
pubmed: 32756005
Cell Mol Neurobiol. 2019 Mar;39(2):287-300
pubmed: 30607810
Front Immunol. 2014 Oct 20;5:520
pubmed: 25368619
Behav Brain Res. 2011 Aug 1;221(1):7-12
pubmed: 21356250
Sci Rep. 2015 Jan 14;5:7771
pubmed: 25586780
Psychosom Med. 2003 Mar-Apr;65(2):211-21
pubmed: 12651988
J Neurosci. 2003 Oct 22;23(29):9687-95
pubmed: 14573548
Chem Biol Interact. 2020 Jan 5;315:108895
pubmed: 31715133
Altern Med Rev. 2003 Aug;8(3):223-46
pubmed: 12946237
PLoS One. 2013 Jun 07;8(6):e64076
pubmed: 23762236
Oxid Med Cell Longev. 2015;2015:234952
pubmed: 25945148
Front Cell Neurosci. 2018 Feb 28;12:49
pubmed: 29599709
J Psychiatr Res. 2020 Nov;130:260-272
pubmed: 32858346
Sleep Med Rev. 2009 Jun;13(3):187-94
pubmed: 18848476
Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R947-55
pubmed: 10749783
Gut. 2003 Jan;52(1):65-70
pubmed: 12477762
Nat Sci Sleep. 2012 Mar 06;4:19-31
pubmed: 23616726
Physiol Behav. 2020 Oct 1;224:113023
pubmed: 32574661
Clin Immunol Immunopathol. 1987 Dec;45(3):461-70
pubmed: 2445511
AIDS Behav. 2011 Nov;15(8):1888-94
pubmed: 21437726
J Alzheimers Dis. 2020;74(3):759-773
pubmed: 32083588
Sci Rep. 2015 Apr 01;5:9513
pubmed: 25830666
Behav Brain Res. 2021 Jan 1;396:112901
pubmed: 32920013
Int J Biol Sci. 2015 Jun 06;11(8):901-12
pubmed: 26157345
Brain Res. 2020 May 1;1734:146739
pubmed: 32087111
J Assoc Nurses AIDS Care. 2016 Jan-Feb;27(1):5-16
pubmed: 26547298
Sci Rep. 2017 Apr 04;7:45528
pubmed: 28374797
Eur J Immunol. 1996 Jun;26(6):1217-21
pubmed: 8647195
Cell Mol Neurobiol. 2018 Jan;38(1):53-71
pubmed: 28534246
PLoS One. 2014 Dec 22;9(12):e114155
pubmed: 25531437
Neuropsychopharmacology. 2015 Jan;40(2):502-12
pubmed: 25103178
EBioMedicine. 2015 May 30;2(7):755-64
pubmed: 26286205
PLoS One. 2014 Jul 03;9(7):e99258
pubmed: 24991815
Clin Immunol. 2017 Dec;185:100-108
pubmed: 27570219
Iran J Immunol. 2012 Jun;9(2):86-97
pubmed: 22735796
Physiol Behav. 2020 Mar 1;215:112788
pubmed: 31863855
Sci Rep. 2018 Sep 14;8(1):13837
pubmed: 30218019
Infect Dis (Lond). 2021 Feb;53(2):81-88
pubmed: 32955957
Nat Immunol. 2005 Nov;6(11):1123-32
pubmed: 16200070