Antibiotics
CBM588
clostridium butyricum
gut microbiome
immune checkpoint blockade
lung cancer
oral microbiota
proton pump inhibitors (PPIs)
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Oral microbiota is associated with human diseases including cancer. Emerging evidence suggests that proton pump inhibitors (PPIs), which allow the oral microbiome to translocate into the gut, negatively influence the efficacy of immune checkpoint blockade (ICB) in cancer patients. However, currently there is no effective treatment that restores the decreased efficacy. To address this issue, we retrospectively evaluated 118 advanced or recurrent non-small cell lung cancer (NSCLC) patients treated with ICB and analyzed 80 fecal samples of patients with lung cancer by 16S metagenomic sequencing.
Identifiants
pubmed: 35655708
doi: 10.1080/2162402X.2022.2081010
pii: 2081010
pmc: PMC9154751
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Proton Pump Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2081010Informations de copyright
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
Takuro Sakagami received research funding from Miyarisan Pharmaceutical Co., Ltd. to his institution. Ayaka Minemura, Kentaro Oka, Atsushi Hayashi, and Motomichi Takahashi are employees of Miyarisan Pharmaceutical Co., Ltd. Yusuke Tomita received fundings from the JSPS KAKENHI (Grant Number 18K15928 and 22K08256). Shinya Sakata received funding from the JSPS KAKENHI (Grant Number 20K16449). The other authors have no conflicts of interest to declare.
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