Change in Latent Gray-Matter Structural Integrity Is Associated With Change in Cardiovascular Fitness in Older Adults Who Engage in At-Home Aerobic Exercise.
aging
brain structure integrity
fitness
older adults
physical activity
structural equation modeling
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
01
2022
accepted:
15
03
2022
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
epublish
Résumé
In aging humans, aerobic exercise interventions have been found to be associated with more positive or less negative changes in frontal and temporal brain areas, such as the anterior cingulate cortex (ACC) and hippocampus, relative to no-exercise control conditions. However, individual measures such as gray-matter (GM) probability may afford less reliable and valid conclusions about maintenance or losses in structural brain integrity than a latent construct based on multiple indicators. Here, we established a latent factor of GM structural integrity based on GM probability assessed by voxel-based morphometry, magnetization transfer saturation, and mean diffusivity. Based on this latent factor, we investigated changes in structural brain integrity during a six-month exercise intervention in brain regions previously reported in studies using volumetric approaches. Seventy-five healthy, previously sedentary older adults aged 63-76 years completed an at-home intervention study in either an exercise group (EG;
Identifiants
pubmed: 35655926
doi: 10.3389/fnhum.2022.852737
pmc: PMC9152142
doi:
Types de publication
Journal Article
Langues
eng
Pagination
852737Informations de copyright
Copyright © 2022 Polk, Kleemeyer, Köhncke, Brandmaier, Bodammer, Misgeld, Porst, Wolfarth, Kühn, Lindenberger, Wenger and Düzel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Exp Physiol. 2017 Nov 1;102(11):1356-1371
pubmed: 28786150
J Neurosci. 2013 Nov 20;33(47):18618-30
pubmed: 24259583
Educ Psychol Meas. 2015 Jun 1;75(3):458-474
pubmed: 27065479
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
pubmed: 17167157
J Neurosci. 2009 Dec 2;29(48):15223-31
pubmed: 19955375
Cereb Cortex. 2021 Feb 5;31(3):1464-1477
pubmed: 33150357
Clin Rehabil. 2008 Oct-Nov;22(10-11):987-96
pubmed: 18955430
Neurobiol Aging. 2012 Aug;33(8):1624-32
pubmed: 21531480
Annu Rev Psychol. 2019 Jan 4;70:219-243
pubmed: 29949727
J Alzheimers Dis. 2014;42 Suppl 3:S229-37
pubmed: 24840568
Neuroimage. 2011 Feb 1;54(3):2116-24
pubmed: 20965260
Sports Med. 2007;37(9):765-82
pubmed: 17722948
J Gerontol A Biol Sci Med Sci. 2003 Feb;58(2):176-80
pubmed: 12586857
Brain Behav Immun. 2012 Jul;26(5):811-9
pubmed: 22172477
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Neuroimage. 2016 May 1;131:155-61
pubmed: 26584869
Neuroimage. 2010 Feb 1;49(3):2457-66
pubmed: 19818860
Neurobiol Aging. 2011 Jul;32(7):1304-19
pubmed: 19716631
Front Aging Neurosci. 2013 Nov 12;5:75
pubmed: 24282403
Psychometrika. 2016 Jun;81(2):535-49
pubmed: 25622929
Neuroimage. 2016 May 1;131:48-54
pubmed: 26505299
Neuroimage. 2019 Jul 1;194:191-210
pubmed: 30677501
Dev Cogn Neurosci. 2018 Oct;33:99-117
pubmed: 29325701
Magn Reson Med. 2008 Mar;59(3):667-72
pubmed: 18306368
Neurobiol Aging. 2011 Aug;32(8):1466-76
pubmed: 19781814
Geroscience. 2020 Oct;42(5):1285-1306
pubmed: 32767221
Nat Neurosci. 2012 Mar 18;15(4):528-36
pubmed: 22426254
Neuroimage. 2005 May 15;26(1):132-40
pubmed: 15862213
Front Neurosci. 2013 Jun 10;7:95
pubmed: 23772204
Mol Psychiatry. 2015 May;20(5):585-93
pubmed: 25311366
Neuroimage. 2001 Jul;14(1 Pt 1):21-36
pubmed: 11525331
Rev Neurosci. 2010;21(3):187-221
pubmed: 20879692
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Cereb Cortex. 2005 Nov;15(11):1676-89
pubmed: 15703252
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Trends Cogn Sci. 2012 May;16(5):292-305
pubmed: 22542563
Science. 2014 Oct 31;346(6209):572-8
pubmed: 25359964
Sci Rep. 2017 Sep 20;7(1):11920
pubmed: 28931835
Gerontology. 2018;64(1):49-57
pubmed: 28858861
Nat Rev Neurosci. 2012 Mar 07;13(4):240-50
pubmed: 22395804
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Gerontology. 2004 Jan-Feb;50(1):12-6
pubmed: 14654721
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Neuropsychology. 2012 Mar;26(2):144-55
pubmed: 22149165
Sci Rep. 2019 Aug 22;9(1):12246
pubmed: 31439874
Appl Psychol Meas. 2015 Oct;39(7):573-574
pubmed: 29881028
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Trends Neurosci. 2004 Oct;27(10):607-13
pubmed: 15374672
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
Neuroimage. 2009 Mar;45(1 Suppl):S173-86
pubmed: 19059349
Nat Rev Neurosci. 2018 Nov;19(11):701-710
pubmed: 30305711
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Magn Reson Med. 1996 Dec;36(6):893-906
pubmed: 8946355
Front Med (Lausanne). 2019 Oct 04;6:204
pubmed: 31637242
Magn Reson Med. 2008 Dec;60(6):1396-407
pubmed: 19025906
Psychol Sci Public Interest. 2008 Oct;9(1):1-65
pubmed: 26162004
Psychol Aging. 2005 Sep;20(3):423-34
pubmed: 16248702
NMR Biomed. 2002 Nov-Dec;15(7-8):435-55
pubmed: 12489094