Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid:
Apoptosis
BAX
BCL-2
Fulvic acid
Humic acid
Melanoma
Tyrosinase
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
28
09
2021
accepted:
18
04
2022
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
ppublish
Résumé
Humic acid (HA) and Fulvic acid (FA) are major members of humic substances, which are extracted from organic sources including soil and peat. The pro-apoptotic and anti-melanogenic effects of HA and FA at the cellular and molecular levels in the A375 human melanoma cell line were examined in this study. The cytotoxicity effect of HA and FA were evaluated by cell viability assay. Apoptosis and cell cycle were investigated by flow cytometry. Real-time PCR was carried out to measure the expression of It was found that HA and FA decrease cell viability with an IC These results exhibited that HA and FA possess pro-apoptotic effects through increasing the
Identifiants
pubmed: 35656077
doi: 10.22038/IJBMS.2022.60651.13444
pmc: PMC9150800
doi:
Types de publication
Journal Article
Langues
eng
Pagination
489-496Déclaration de conflit d'intérêts
The authors of this study have no conflicts of interests.
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