Autophagy and Renal Fibrosis.
autophagy
cellular senescence
chronic kidney disease
renal fibrosis
senescence-associated secretory phenotype
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
03
08
2021
accepted:
27
10
2021
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
epublish
Résumé
Renal fibrosis is a common process of almost all the chronic kidney diseases progressing to end-stage kidney disease. As a highly conserved lysosomal protein degradation pathway, autophagy is responsible for degrading protein aggregates, damaged organelles, or invading pathogens to maintain intracellular homeostasis. Growing evidence reveals that autophagy is involved in the progression of renal fibrosis, both in the tubulointerstitial compartment and in the glomeruli. Nevertheless, the specific role of autophagy in renal fibrosis has still not been fully understood. Therefore, in this review we will describe the characteristics of autophagy and summarize the recent advances in understanding the functions of autophagy in renal fibrosis. Moreover, the problem existing in this field and the possibility of autophagy as the potential therapeutic target for renal fibrosis have also been discussed.
Identifiants
pubmed: 35656109
doi: 10.14336/AD.2021.1027
pii: ad-13-3-712
pmc: PMC9116923
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
712-731Informations de copyright
Copyright: © 2022 Liang et al.
Déclaration de conflit d'intérêts
Competing interests All authors declare no conflict of interest.
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