Vascular Calcification in Chronic Kidney Disease: An Update and Perspective.
aging
biomarker
chronic kidney disease
metabolism
vascular calcification
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
27
09
2021
accepted:
24
10
2021
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
epublish
Résumé
Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron numbers and function and leading to end-stage renal disease and mineral disorders. Vascular calcification, an ectopic deposition of calcium-phosphate salts in blood vessel walls and heart valves, is an independent risk factor of cardiovascular morbidity and mortality in chronic kidney disease. Moreover, aging and related metabolic disorders are essential risk factors for chronic kidney disease and vascular calcification. Marked progress has been recently made in understanding and treating vascular calcification in chronic kidney disease. However, there is a paucity of systematic reviews summarizing this progress, and investigating unresolved issues is warranted. In this systematic review, we aimed to overview the underlying mechanisms of vascular calcification in chronic kidney diseases and discuss the impact of chronic kidney disease on the pathophysiology of vascular calcification. Additionally, we summarized potential clinical diagnostic biomarkers and therapeutic applications for vascular calcification with chronic kidney disease. This review may offer new insights into the pathogenesis, diagnosis, and therapeutic intervention of vascular calcification.
Identifiants
pubmed: 35656113
doi: 10.14336/AD.2021.1024
pii: ad-13-3-673
pmc: PMC9116919
doi:
Types de publication
Journal Article
Langues
eng
Pagination
673-697Informations de copyright
Copyright: © 2022 Ren et al.
Déclaration de conflit d'intérêts
Conflicts of interest All authors declare that there are no conflicts of interest or competing interests.
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