Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study.
Cardiovascular diseases
Glucose
Mortality
Triglyceride
Young adult
Journal
Journal of lipid and atherosclerosis
ISSN: 2287-2892
Titre abrégé: J Lipid Atheroscler
Pays: Korea (South)
ID NLM: 101610890
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
21
12
2021
revised:
10
03
2022
accepted:
23
03
2022
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
ppublish
Résumé
The triglyceride-glucose (TyG) index, the product of fasting triglycerides and glucose, is a useful and cost-effective marker of insulin resistance (IR). Furthermore, the TyG index is a known IR screening tool in healthy young adults but not in those with atherosclerotic cardiovascular disease (CVD). Thus, this study aimed to evaluate the TyG index as a predictor of CVD in healthy young adults. This study enrolled 6,675,424 adults aged 20-39 years without CVD from the National Health Information Database. We categorized them by TyG index quartile from 2009-2017. The study outcomes were stroke, myocardial infarction (MI), and mortality. All outcomes were analyzed by Cox proportional hazards regression analysis while controlling for baseline covariates. During a mean 7.4 years of follow-up, 8,506 cases of stroke, 12,312 cases of MI, and 22,667 deaths were recorded. Multivariable-adjusted hazard ratios (HRs) for participants in the highest TyG index quartile demonstrated that they were at higher risk for stroke (HR, 1.253; 95% confidence interval [CI], 1.167-1.346), MI (HR, 1.258; 95% CI, 1.187-1.334), and mortality (HR, 1.151; 95% CI, 1.104-1.200) than those in the lowest TyG index quartile independent of age, sex, smoking, alcohol consumption, physical activity, income, body mass index, blood pressure, and total cholesterol. The HRs for outcomes in the highest quartiles were higher when the TyG index was applied than when triglyceride or fasting glucose alone was applied. TyG index, a simple measure reflecting IR, can predict CVD and mortality in young and healthy populations.
Identifiants
pubmed: 35656153
doi: 10.12997/jla.2022.11.2.178
pmc: PMC9133778
doi:
Types de publication
Journal Article
Langues
eng
Pagination
178-186Informations de copyright
Copyright © 2022 The Korean Society of Lipid and Atherosclerosis.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
Références
Metabolism. 2011 Dec;60(12):1673-6
pubmed: 21632070
Int J Epidemiol. 2017 Apr 1;46(2):e15
pubmed: 26822938
J Clin Invest. 2000 Aug;106(4):473-81
pubmed: 10953022
Arch Med Res. 2016 Jul;47(5):382-387
pubmed: 27751372
Metabolism. 1978 Dec;27(12 Suppl 2):1893-902
pubmed: 723640
Diabetes Metab J. 2014 Oct;38(5):395-403
pubmed: 25349827
J Clin Invest. 2000 Aug;106(4):453-8
pubmed: 10953019
Diabetologia. 2003 Jan;46(1):3-19
pubmed: 12637977
Diabetes. 1988 Dec;37(12):1595-607
pubmed: 3056758
Diabetes Metab Syndr. 2019 Jan - Feb;13(1):272-277
pubmed: 30641711
Physiol Rev. 2018 Oct 1;98(4):2133-2223
pubmed: 30067154
Clin Chim Acta. 2017 Jan;464:57-63
pubmed: 27836689
Ann Intern Med. 1990 Dec 15;113(12):909-15
pubmed: 2240915
Metab Syndr Relat Disord. 2008 Dec;6(4):299-304
pubmed: 19067533
Cardiovasc Diabetol. 2014 Oct 20;13:146
pubmed: 25326814
J Am Coll Cardiol. 2007 May 29;49(21):2112-9
pubmed: 17531661
BMC Med. 2020 Nov 25;18(1):361
pubmed: 33234146
Diabetes Res Clin Pract. 2011 Sep;93(3):e98-e100
pubmed: 21665314
Cardiovasc Diabetol. 2020 Jan 15;19(1):8
pubmed: 31941513
Cardiovasc Diabetol. 2020 Sep 29;19(1):155
pubmed: 32993633
Am J Physiol. 1982 Jul;243(1):E15-30
pubmed: 7046470
Nature. 2006 Dec 14;444(7121):840-6
pubmed: 17167471
Metabolism. 1981 Feb;30(2):165-71
pubmed: 7007804
Nat Med. 2017 Jul 11;23(7):804-814
pubmed: 28697184
Eur J Clin Invest. 2016 Feb;46(2):189-97
pubmed: 26683265
J Clin Endocrinol Metab. 2010 Jul;95(7):3347-51
pubmed: 20484475
J Lipid Atheroscler. 2021 Jan;10(1):88-98
pubmed: 33537256