Neuroprotective effect of L-deprenyl on the expression level of the Mst1 gene and inhibition of apoptosis in rat-model spinal cord injury.
Apoptosis
Bcl-2
Contusion
L-deprenyl
Mst1
Nrf2
Selegiline
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
28
05
2021
accepted:
26
12
2021
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
4
6
2022
Statut:
ppublish
Résumé
After primary tissue damage as a result of spinal cord injury (SCI), there is a period of secondary damage, which includes several cellular and inflammatory biochemical cascades. As a novel pro-apoptotic kinase, The rats were divided into control (contusion), laminectomy, sham-operated (contused rats received 1 ml normal saline intraperitoneal), and treatment (contused rats received 5 mg/kg of L-deprenyl intraperitoneal; once a day for 7 days). The BBB (Basso, Beattie, and Bresnahan) scales were performed to assess motor function following SCI. Rats were sacrificed 28 days after SCI and the spinal cord lesion area was removed. Apoptosis and cavity formation in the spinal cord were determined by H&E staining and TUNEL assay, respectively. The mRNA levels of the The results showed significant improvement in motor function in the L- deprenyl group compared with the untreated group. Histological analysis showed a significant reduction in the number of tunnel-positive cells after injection of L-deprenyl, as well as a decrease in the volume of the cavity. In addition, L-deprenyl treatment increased the expression of the These results suggest that L-deprenyl is a promising treatment for spinal cord injury.
Identifiants
pubmed: 35656451
doi: 10.22038/IJBMS.2022.58031.12894
pmc: PMC9118276
doi:
Types de publication
Journal Article
Langues
eng
Pagination
53-59Déclaration de conflit d'intérêts
The authors declare that they do not have any conflicts of interest. We affirm that we have read the policy of the journal on issues related to ethical publishing and that this report is consistent with those guidelines.
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