LECT2: A pleiotropic and promising hepatokine, from bench to bedside.
LECT2
biomarker
hepatokine
target
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
12
03
2022
received:
14
11
2021
accepted:
02
05
2022
pubmed:
4
6
2022
medline:
9
7
2022
entrez:
3
6
2022
Statut:
ppublish
Résumé
LECT2 (leucocyte cell-derived chemotaxin 2) is a 16-kDa protein mainly produced by hepatocytes. It was first isolated in PHA-activated human T-cell leukaemia SKW-3 cells and originally identified as a novel neutrophil chemotactic factor. However, many lines of studies suggested that LECT2 was a pleiotropic protein, it not only functioned as a cytokine to exhibit chemotactic property, but also played multifunctional roles in some physiological conditions and pathological abnormalities, involving liver regeneration, neuronal development, HSC(haematopoietic stem cells) homeostasis, liver injury, liver fibrosis, hepatocellular carcinoma, metabolic disorders, inflammatory arthritides, systemic sepsis and systemic amyloidosis. Among the above studies, it was discovered that LECT2 could be a promising molecular biomarker and therapeutic target. This review summarizes LECT2-related receptors and pathways, basic and clinical researches, primarily in mice and human, for a better comprehension and management of these diseases in the future.
Identifiants
pubmed: 35656863
doi: 10.1111/jcmm.17407
pmc: PMC9258709
doi:
Substances chimiques
Chemotactic Factors
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3598-3607Subventions
Organisme : Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer
ID : 2020B121201004
Organisme : Key-Area Research and Development Program of Guangdong Province
ID : 2019B020234003
Organisme : National Natural Science Foundation of China
ID : 92068206
Informations de copyright
© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Références
PLoS One. 2014 Jun 03;9(6):e98817
pubmed: 24892551
Neuroreport. 2010 Jun 23;21(9):646-50
pubmed: 20463617
Hepatology. 2019 Jan;69(1):160-178
pubmed: 30070727
World J Hepatol. 2021 Dec 27;13(12):2071-2080
pubmed: 35070009
J Exp Med. 2013 Jan 14;210(1):5-13
pubmed: 23254286
Arthritis Rheum. 2008 Feb;58(2):413-21
pubmed: 18240267
Nat Rev Clin Oncol. 2011 May;8(5):292-301
pubmed: 21386818
FEBS Lett. 2013 Mar 1;587(5):404-9
pubmed: 23352894
Genomics. 1998 Mar 15;48(3):324-9
pubmed: 9545637
Amyloid. 2014 Dec;21(4):221-4
pubmed: 25263598
Cell. 2019 Sep 5;178(6):1478-1492.e20
pubmed: 31474362
Amyloid. 2011 Jun;18 Suppl 1:223-5
pubmed: 21838496
Brain Res. 2010 Jan 22;1311:1-11
pubmed: 19917270
Biol Pharm Bull. 2001 Apr;24(4):425-8
pubmed: 11305608
J Mol Endocrinol. 2018 Jul;61(1):37-45
pubmed: 29650721
Cancer Gene Ther. 2011 Jun;18(6):399-406
pubmed: 21394108
Clin Immunol. 2010 Dec;137(3):311-21
pubmed: 20805039
Bone Marrow Transplant. 2005 Nov;36(10):847-53
pubmed: 16113660
Biosci Trends. 2013 Dec;7(6):276-83
pubmed: 24390366
Adv Immunol. 2007;96:41-101
pubmed: 17981204
FEBS Lett. 1997 Apr 14;406(3):310-4
pubmed: 9136908
Hepatology. 2014 Mar;59(3):974-85
pubmed: 24114941
Blood. 2011 Oct 27;118(17):4530-40
pubmed: 21832280
Arthritis Rheum. 2000 Jun;43(6):1419-20
pubmed: 10857804
Chest. 2003 Jun;123(6):2043-9
pubmed: 12796187
Biomed Res. 2007 Oct;28(5):247-53
pubmed: 18000337
Blood. 2014 Mar 6;123(10):1479-82
pubmed: 24415538
Sci Rep. 2021 Jan 12;11(1):555
pubmed: 33436955
Hepatol Res. 2015 Jan;45(1):1-9
pubmed: 24533487
Clin J Am Soc Nephrol. 2013 Sep;8(9):1515-23
pubmed: 23704299
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1310-6
pubmed: 27562717
Kidney Int. 2008 Jul;74(2):218-22
pubmed: 18449172
J Biol Chem. 2016 Aug 12;291(33):17133-42
pubmed: 27334921
Biochim Biophys Acta. 1998 Mar 4;1396(1):105-13
pubmed: 9524238
Transplant Proc. 2004 Oct;36(8):2359-61
pubmed: 15561249
Front Mol Biosci. 2021 Sep 22;8:749648
pubmed: 34631799
Kidney Int. 2010 May;77(9):816-9
pubmed: 20182418
Immunol Lett. 1996 Aug;52(1):9-13
pubmed: 8877413
Biochem Pharmacol. 2015 Nov 1;98(1):157-66
pubmed: 26297911
J Biol Chem. 2021 Jan-Jun;296:100446
pubmed: 33617884
Hepatology. 2015 Jun;61(6):2042-55
pubmed: 25475053
Gastroenterology. 2014 May;146(5):1339-50.e1
pubmed: 24503129
Am J Kidney Dis. 2010 Dec;56(6):1100-7
pubmed: 20951486
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
Metabolism. 2015 Sep;64(9):1175-82
pubmed: 26123523
Diabetes. 2014 May;63(5):1649-64
pubmed: 24478397
Sci Rep. 2016 Aug 10;6:31398
pubmed: 27507763
J Immunol. 2004 Jul 1;173(1):579-85
pubmed: 15210819
Hepatology. 2004 Jul;40(1):167-76
pubmed: 15239100
Pathol Int. 1998 Nov;48(11):882-6
pubmed: 9832057
Pathol Int. 1999 Feb;49(2):147-51
pubmed: 10355968
Hepatology. 2022 Sep;76(3):660-675
pubmed: 34940991
Nat Commun. 2016 Sep 06;7:12719
pubmed: 27596364
Genet Mol Res. 2016 Oct 24;15(4):
pubmed: 27813598
Kidney Int. 2014 Aug;86(2):370-7
pubmed: 24451324
Biochem Biophys Rep. 2017 Oct 13;12:166-171
pubmed: 29090278
PLoS One. 2017 Mar 9;12(3):e0173310
pubmed: 28278265
Intensive Care Med. 1998 Oct;24(10):1052-6
pubmed: 9840239
Adv Ther. 2017 Nov;34(11):2393-2411
pubmed: 29022217
J Cell Mol Med. 2022 Jul;26(13):3598-3607
pubmed: 35656863
J Biol Chem. 1996 Sep 13;271(37):22657-62
pubmed: 8798437
Kidney Int. 2014 Aug;86(2):378-82
pubmed: 24522497
Protein Expr Purif. 2013 Apr;88(2):221-9
pubmed: 23337084
Microbiol Immunol. 2012 Oct;56(10):708-18
pubmed: 22725643
Hepatology. 2015 Jun;61(6):1790-2
pubmed: 25641396
Semin Immunol. 2019 Jun;43:101280
pubmed: 31221552