Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T

Allergens Animals Asthma Disease Models, Animal Dogs Hypersensitivity / metabolism Mice Pyroglyphidae Respiration Disorders Respiratory Hypersensitivity / metabolism Th2 Cells
TH17 TH2 allergen immune therapy dog allergy single cell RNA-Seq

Journal

Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028

Informations de publication

Date de publication:
10 2022
Historique:
revised: 27 04 2022
received: 15 11 2021
accepted: 02 05 2022
pubmed: 4 6 2022
medline: 1 10 2022
entrez: 3 6 2022
Statut: ppublish

Résumé

Allergy to dogs affects around 10% of the population in developed countries. Immune therapy of allergic patients with dog allergen extracts has shown limited therapeutic benefit. We established a mouse model of dog allergy by repeatedly administering dog dander and epithelium extracts via the intranasal route. We also assessed the efficacy of a recombinant multimeric protein containing Can f 1, f 2, f 4 and f 6 in preventing inflammatory responses to dog extracts. Repeated inhalation of dog extracts induced infiltration of the airways by T Dog allergen extracts induce robust T

Sections du résumé

BACKGROUND
Allergy to dogs affects around 10% of the population in developed countries. Immune therapy of allergic patients with dog allergen extracts has shown limited therapeutic benefit.
METHODS
We established a mouse model of dog allergy by repeatedly administering dog dander and epithelium extracts via the intranasal route. We also assessed the efficacy of a recombinant multimeric protein containing Can f 1, f 2, f 4 and f 6 in preventing inflammatory responses to dog extracts.
RESULTS
Repeated inhalation of dog extracts induced infiltration of the airways by T
CONCLUSION
Dog allergen extracts induce robust T

Identifiants

DOI: 10.1111/all.15399 PMID: 35657107 PMC: PMC9796107
pubmed: 35657107
doi: 10.1111/all.15399
pmc: PMC9796107
doi:

Substances chimiques

Allergens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2987-3001

Informations de copyright

© 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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Auteurs

Julian M Stark (JM)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-3961-6315

Jielu Liu (J)

Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-0850-8258

Christopher A Tibbitt (CA)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-7730-7700

Murray Christian (M)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Junjie Ma (J)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Anna Wintersand (A)

Department of Clinical Neuroscience, Karolinska Institutet, Centre for Molecular Medicine, Stockholm, Sweden.

Josefine Dunst (J)

Department of Medicine, Division of Immunology and Allergy, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Taras Kreslavsky (T)

Department of Medicine, Division of Immunology and Allergy, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Ben Murrell (B)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Mikael Adner (M)

Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.

Hans Grönlund (H)

Department of Clinical Neuroscience, Karolinska Institutet, Centre for Molecular Medicine, Stockholm, Sweden.
ORCID: 0000-0003-4882-7624

Guro Gafvelin (G)

Department of Clinical Neuroscience, Karolinska Institutet, Centre for Molecular Medicine, Stockholm, Sweden.
ORCID: 0000-0003-1618-4011

Jonathan M Coquet (JM)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-5967-4857

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Classifications MeSH

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questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Recombinant multimeric dog allergen prevents...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Recombinant multimeric dog allergen prevents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Recombinant multimeric dog allergen prevents...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Recombinant multimeric dog allergen prevents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Recombinant multimeric dog allergen prevents...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Arachnida › Acari › Mites (acariens) › Pyroglyphidae › Recombinant multimeric dog allergen prevents...
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questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › Recombinant multimeric dog allergen prevents...