An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
03 06 2022
03 06 2022
Historique:
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
9
6
2022
Statut:
ppublish
Résumé
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33-activated ILC2s were previously found to augment protective tissue-specific pancreatic cancer immunity. Here, we showed that intestinal IL-25-activated ILC2s created an innate cancer-permissive microenvironment. Colorectal cancer (CRC) patients with higher tumor
Identifiants
pubmed: 35658010
doi: 10.1126/sciimmunol.abn0175
pmc: PMC7612821
mid: EMS144798
doi:
Substances chimiques
APC protein, human
0
Adenomatous Polyposis Coli Protein
0
Interleukin-17
0
Interleukin-33
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn0175Subventions
Organisme : Wellcome Trust
ID : 100963
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220223
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105178805
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-104-0013-S-MCKEN-C0902
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
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