Pharmacological mechanism of xanthoangelol underlying Nrf-2/TRPV1 and anti-apoptotic pathway against scopolamine-induced amnesia in mice.

Alzheimer Disease / drug therapy Amnesia / chemically induced Animals Antioxidants / pharmacology Chalcone / analogs & derivatives GA-Binding Protein Transcription Factor / metabolism Hydrogen Peroxide / metabolism Maze Learning Mice Neuroprotective Agents Oxidative Stress Scopolamine / pharmacology TRPV Cation Channels / metabolism
Alzheimer’s disease Apoptosis Neurodegeneration Neuroprotection Oxidative stress Xanthoangelol

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 11 02 2022
revised: 26 04 2022
accepted: 29 04 2022
entrez: 5 6 2022
pubmed: 6 6 2022
medline: 9 6 2022
Statut: ppublish

Résumé

Alzheimer's disease (AD) is a well-known type of age-related dementia. The present study was conducted to investigate the effect of xanthoangelol against memory deficit and neurodegeneration associated with AD. Preliminarily, xanthoangelol produced neuroprotective effect against H

Identifiants

DOI: 10.1016/j.biopha.2022.113073 PMID: 35658216
pubmed: 35658216
pii: S0753-3322(22)00462-0
doi: 10.1016/j.biopha.2022.113073
pii:
doi:

Substances chimiques

Antioxidants 0
GA-Binding Protein Transcription Factor 0
Neuroprotective Agents 0
TRPV Cation Channels 0
TRPV1 protein, mouse 0
Chalcone 5S5A2Q39HX
xanthoangelol 62949-76-2
Hydrogen Peroxide BBX060AN9V
Scopolamine DL48G20X8X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113073

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Zunaira Syed (Z)

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Bushra Shal (B)

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Faculty of Health Sciences, IQRA University, Islamabad Campus, (Chak Shahzad), Islamabad, Pakistan.

Aqsa Azhar (A)

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Safa Amanat (S)

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Adnan Khan (A)

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Hussain Ali (H)

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Yun-Seo Kil (YS)

College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, South Korea.

Eun Kyoung Seo (EK)

College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, South Korea. Electronic address: yuny@ewha.ac.kr.

Salman Khan (S)

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: skhan@qau.edu.pk.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Amnésie › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Eucaryotes › Animaux › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Chalcones › Chalcone › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs nucléaires de la chaîne respiratoire › Facteur de transcription GABP › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Tropanes › Dérivés de la scopolamine › Scopolamine › Pharmacological mechanism of xanthoangelol...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Pharmacological mechanism of xanthoangelol...