Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.

Animals Apolipoproteins E Arsenic / toxicity Atherosclerosis / chemically induced Cardiovascular Diseases / chemically induced DNA Methylation Female Humans Male Mice Middle Aged Prospective Studies
DNA methylation arsenic cardiovascular diseases

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
08 07 2022
Historique:
pubmed: 7 6 2022
medline: 26 7 2022
entrez: 6 6 2022
Statut: ppublish

Résumé

Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD. Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of the Strong Heart Study, a prospective cohort of American Indians. Urinary arsenic species were measured using high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry. We identified DMPs that are potential mediators between arsenic and CVD. In a cross-species analysis, we compared those DMPs with differential liver DNA methylation following early-life arsenic exposure in the apoE knockout (apoE A total of 20 and 13 DMPs were potential mediators for CVD incidence and mortality, respectively, several of them annotated to genes related to diabetes. Eleven of these DMPs were similarly associated with incident CVD in 3 diverse prospective cohorts (Framingham Heart Study, Women's Health Initiative, and Multi-Ethnic Study of Atherosclerosis). In the mouse model, differentially methylated regions in 20 of those genes and DMPs in 10 genes were associated with arsenic. Differential DNA methylation might be part of the biological link between arsenic and CVD. The gene functions suggest that diabetes might represent a relevant mechanism for arsenic-related cardiovascular risk in populations with a high burden of diabetes.

Sections du résumé

BACKGROUND
Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD.
METHODS
Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of the Strong Heart Study, a prospective cohort of American Indians. Urinary arsenic species were measured using high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry. We identified DMPs that are potential mediators between arsenic and CVD. In a cross-species analysis, we compared those DMPs with differential liver DNA methylation following early-life arsenic exposure in the apoE knockout (apoE
RESULTS
A total of 20 and 13 DMPs were potential mediators for CVD incidence and mortality, respectively, several of them annotated to genes related to diabetes. Eleven of these DMPs were similarly associated with incident CVD in 3 diverse prospective cohorts (Framingham Heart Study, Women's Health Initiative, and Multi-Ethnic Study of Atherosclerosis). In the mouse model, differentially methylated regions in 20 of those genes and DMPs in 10 genes were associated with arsenic.
CONCLUSIONS
Differential DNA methylation might be part of the biological link between arsenic and CVD. The gene functions suggest that diabetes might represent a relevant mechanism for arsenic-related cardiovascular risk in populations with a high burden of diabetes.

Identifiants

DOI: 10.1161/CIRCRESAHA.122.320991 PMID: 35658476 PMC: PMC10203287
pubmed: 35658476
doi: 10.1161/CIRCRESAHA.122.320991
pmc: PMC10203287
mid: NIHMS1893603
doi:

Substances chimiques

Apolipoproteins E 0
Arsenic N712M78A8G

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e51-e69

Subventions

Organisme : NHLBI NIH HHS
ID : 75N92019D00030
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00007
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109282
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00005
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL041642
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG003067
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL041654
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600002C
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Organisme : NIEHS NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
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Organisme : NHLBI NIH HHS
ID : HHSN268201500001C
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
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Organisme : NHLBI NIH HHS
ID : HHSN268201600018C
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Organisme : NHLBI NIH HHS
ID : 75N92020D00001
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025216
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES033719
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090863
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL041652
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00029
Pays : United States
Organisme : NHLBI NIH HHS
ID : N02HL64278
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00003
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010349
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146860
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109315
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00028
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600038C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00004
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109319
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109284
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL065521
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00031
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151855
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00027
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00006
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109301
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL065520
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021367
Pays : United States

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Auteurs

Arce Domingo-Relloso (A)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.).
Department of Statistics and Operations Research (A.D.-R.), University of Valencia, Spain.
ORCID: 0000-0001-6928-8290

Kiran Makhani (K)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.).

Angela L Riffo-Campos (AL)

Department of Computer Science, ETSE (A.L.R.-C.), University of Valencia, Spain.
Millennium Nucleus on Sociomedicine (SocioMed) and Vicerrectoría Académica, Universidad de La Frontera, Temuco, Chile (A.L.R.-C.).
ORCID: 0000-0001-6300-3338

Maria Tellez-Plaza (M)

Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.).
ORCID: 0000-0002-3850-1228

Kathleen Oros Klein (KO)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.).

Pooja Subedi (P)

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (P.S., J.Z.).

Jinying Zhao (J)

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (P.S., J.Z.).

Katherine A Moon (KA)

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.A.M.).

Anne K Bozack (AK)

Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley (A.K.B.).
ORCID: 0000-0003-0046-5767

Karin Haack (K)

Population Health Program, Texas Biomedical Research Institute, San Antonio' TX (K.H., J.W.K., S.A.C.).
ORCID: 0000-0003-3067-3575

Walter Goessler (W)

Institute of Chemistry - Analytical Chemistry for Health and Environment, University of Graz, Austria (W.G.).
ORCID: 0000-0002-0142-9373

Jason G Umans (JG)

MedStar Health Research Institute, Hyattsville, MD. Now with Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.W.H.).
Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.V.H.).
ORCID: 0000-0002-2746-3350

Lyle G Best (LG)

Missouri Breaks Industries and Research, Inc, Eagle Butte, SD (L.G.B.).

Ying Zhang (Y)

Department of Biostatistics and Epidemiology, The University of Oklahoma Health Sciences Center (Y.Z.).

Miguel Herreros-Martinez (M)

Bioinformatics Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain (M.H.-M.).
ORCID: 0000-0002-7533-0982

Ronald A Glabonjat (RA)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
ORCID: 0000-0003-3104-1940

Kathrin Schilling (K)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
ORCID: 0000-0003-4147-0298

Marta Galvez-Fernandez (M)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.).
ORCID: 0000-0003-1996-7425

Jack W Kent (JW)

Population Health Program, Texas Biomedical Research Institute, San Antonio' TX (K.H., J.W.K., S.A.C.).

Tiffany R Sanchez (TR)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (K.D.T., J.I.R.).
ORCID: 0000-0002-2756-4370

W Craig Johnson (WC)

Department of Biostatistics, University of Washington, Seattle (W.C.J.).
ORCID: 0000-0002-3161-3753

Peter Durda (P)

Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT (P.D., R.P.T.).

Russell P Tracy (RP)

Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT (P.D., R.P.T.).
ORCID: 0000-0002-0080-2420

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (K.D.T., J.I.R.).
ORCID: 0000-0001-7191-1723

Stephen S Rich (SS)

Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA (S.S.R.).
ORCID: 0000-0003-3872-7793

David Van Den Berg (D)

Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles' CA (D.V.D.B.).

Silva Kasela (S)

New York Genome Center (S.K., T.L.).
Department of Systems Biology, Columbia University' NY (S.K., T.L.).
ORCID: 0000-0003-4362-0034

Tuuli Lappalainen (T)

New York Genome Center (S.K., T.L.).
Department of Systems Biology, Columbia University' NY (S.K., T.L.).

Ramachandran S Vasan (RS)

National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.S.V.).
Sections of Preventive Medicine and Epidemiology and Cardiovascular Medicine, Department of Medicine, Department of Epidemiology, Boston University Schools of Medicine and Public Health, MA (R.S.V.).
ORCID: 0000-0001-7357-5970

Roby Joehanes (R)

Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.J., D.L.).
Framingham Heart Study, MA (R.J., D.L.).
ORCID: 0000-0001-5549-9054

Barbara V Howard (BV)

MedStar Health Research Institute, Hyattsville, MD. Now with Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.W.H.).
Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.V.H.).

Daniel Levy (D)

Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.J., D.L.).
Framingham Heart Study, MA (R.J., D.L.).
ORCID: 0000-0003-1843-8724

Kurt Lohman (K)

Department of Medicine, Duke University Medical Center, Durham, NC (K.L., Y.L.).

Yongmei Liu (Y)

Department of Medicine, Duke University Medical Center, Durham, NC (K.L., Y.L.).

M Daniele Fallin (MD)

Departments of Mental Health and Epidemiology, Johns Hopkins University, Baltimore, MD (M.D.F.).

Shelley A Cole (SA)

Population Health Program, Texas Biomedical Research Institute, San Antonio' TX (K.H., J.W.K., S.A.C.).

Koren K Mann (KK)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.).
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada (K.K.M.).

Ana Navas-Acien (A)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
ORCID: 0000-0001-9824-7797

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Arsenic › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Maladies cardiovasculaires › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Arsenic Exposure, Blood DNA Methylation, and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Arsenic Exposure, Blood DNA Methylation, and...