Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer.
Biological function
Biomarker
Cancer
tRNAs
tsRNAs
Journal
Experimental hematology & oncology
ISSN: 2162-3619
Titre abrégé: Exp Hematol Oncol
Pays: England
ID NLM: 101590676
Informations de publication
Date de publication:
03 Jun 2022
03 Jun 2022
Historique:
received:
01
05
2022
accepted:
24
05
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation. tRNA-derived small RNAs (tsRNAs) are derived fragments of tRNAs that are cleaved explicitly under certain conditions. An increasing amount of research has demonstrated that tsRNAs have biological functions rather than just being degradation products. tsRNAs can exert functions such as regulating gene expression to influence cancer progression. Their dysregulation is closely associated with various cancers and can serve as diagnostic and prognostic biomarkers for cancer. This review summarizes the generation, classification, and biological functions of tsRNAs, and highlights the roles of tsRNAs in different cancers and their applications as tumor markers.
Identifiants
pubmed: 35658952
doi: 10.1186/s40164-022-00290-1
pii: 10.1186/s40164-022-00290-1
pmc: PMC9164556
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
35Subventions
Organisme : National Natural Science Foundation of China
ID : No. 81871720, No. 82072363
Organisme : Nantong Municipal Commission of Health and Family Planning
ID : QA2020027
Informations de copyright
© 2022. The Author(s).
Références
J Cell Physiol. 2020 Mar;235(3):2809-2824
pubmed: 31535382
Cold Spring Harb Perspect Biol. 2015 Aug 03;7(8):a019323
pubmed: 26238358
J Exp Clin Cancer Res. 2021 Feb 15;40(1):67
pubmed: 33588913
Cell. 2015 May 7;161(4):790-802
pubmed: 25957686
Nucleic Acids Res. 2009 Oct;37(19):6575-86
pubmed: 19729508
Carcinogenesis. 2021 Oct 5;42(9):1196-1207
pubmed: 34216208
Mol Cancer. 2022 Mar 18;21(1):79
pubmed: 35303879
Cancer Lett. 2019 Jun 28;452:31-37
pubmed: 30905816
Front Genet. 2021 Mar 08;12:638244
pubmed: 33763118
Dis Markers. 2022 Jan 06;2022:2646173
pubmed: 35035608
Onco Targets Ther. 2020 Oct 28;13:10931-10943
pubmed: 33149609
Genes (Basel). 2018 May 10;9(5):
pubmed: 29748504
Mol Ther. 2015 Oct;23(10):1622-9
pubmed: 26156244
BMC Biol. 2014 Oct 01;12:78
pubmed: 25270025
Genes Dev. 2010 Dec 15;24(24):2742-7
pubmed: 21106669
FEBS Lett. 2014 Nov 28;588(23):4297-304
pubmed: 25220675
Int J Med Sci. 2021 Feb 4;18(7):1570-1579
pubmed: 33746573
Nucleic Acids Res. 2008 Nov;36(19):6048-55
pubmed: 18820301
Science. 2016 Jan 22;351(6271):397-400
pubmed: 26721680
J Comput Biol. 2020 Dec;27(12):1644-1655
pubmed: 32392430
Nucleic Acids Res. 2015 Jan;43(Database issue):D141-5
pubmed: 25392422
Front Endocrinol (Lausanne). 2021 May 10;12:670719
pubmed: 34040585
Mol Ther Nucleic Acids. 2020 Sep 4;21:954-964
pubmed: 32814252
J Cell Physiol. 2012 Jul;227(7):2822-6
pubmed: 22021078
Front Genet. 2019 Apr 05;10:290
pubmed: 31024617
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2169-74
pubmed: 25646413
Front Oncol. 2021 May 13;11:679366
pubmed: 34055648
Cell Death Differ. 2011 Feb;18(2):315-27
pubmed: 20725087
Front Oncol. 2021 Aug 23;11:723753
pubmed: 34497770
Cancers (Basel). 2020 Aug 10;12(8):
pubmed: 32785169
Int J Cancer. 2019 Sep 1;145(5):1395-1407
pubmed: 30828790
Science. 2016 Jan 22;351(6271):391-396
pubmed: 26721685
EMBO Rep. 2019 Jul;20(7):e47789
pubmed: 31267708
Annu Rev Genomics Hum Genet. 2019 Aug 31;20:359-387
pubmed: 31082281
J Mol Med (Berl). 2018 Nov;96(11):1167-1176
pubmed: 30232504
Nature. 2017 Dec 7;552(7683):57-62
pubmed: 29186115
Cancer Biomark. 2019;25(2):169-176
pubmed: 31104009
Nat Commun. 2019 Jan 10;10(1):118
pubmed: 30631057
Mol Ther. 2020 Nov 4;28(11):2340-2357
pubmed: 32956625
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Cancer Res. 2017 Jun 15;77(12):3194-3206
pubmed: 28446464
Mol Ther. 2013 Feb;21(2):368-79
pubmed: 23183536
J Cell Physiol. 2019 Jun;234(6):8740-8751
pubmed: 30362543
Plant Cell Physiol. 2018 Jan 1;59(1):e1
pubmed: 29145635
Leuk Lymphoma. 2017 Sep;58(9):1-15
pubmed: 28084850
Trends Biochem Sci. 2019 Mar;44(3):185-189
pubmed: 30297206
PLoS One. 2012;7(12):e52474
pubmed: 23285057
Nat Commun. 2017 Oct 24;8(1):1127
pubmed: 29066746
Nat Struct Mol Biol. 2008 Oct;15(10):1007-14
pubmed: 18836497
Nat Cell Biol. 2019 Feb;21(2):143-151
pubmed: 30602724
Methods. 2021 Mar;187:57-67
pubmed: 33045361
Database (Oxford). 2018 Jan 1;2018:
pubmed: 29939244
Nucleic Acids Res. 2021 Jan 8;49(D1):D1038-D1045
pubmed: 33068436
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8071-8076
pubmed: 28696308
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1404-9
pubmed: 23297232
Cancer Cell Int. 2021 Sep 18;21(1):502
pubmed: 34537070
Front Oncol. 2021 Apr 12;11:656078
pubmed: 33912465
Cell Rep. 2019 Dec 17;29(12):3816-3824.e4
pubmed: 31851915
Front Oncol. 2021 Aug 23;11:733763
pubmed: 34497772
J Biol Chem. 2015 Dec 11;290(50):29761-8
pubmed: 26463210
Leuk Res. 2019 Dec;87:106234
pubmed: 31669784
Mol Cancer. 2022 Jan 18;21(1):21
pubmed: 35042519
Am J Cancer Res. 2020 Feb 01;10(2):393-402
pubmed: 32195016
Nat Rev Genet. 2004 Jul;5(7):522-31
pubmed: 15211354
Nucleic Acids Res. 2018 Jun 1;46(10):5250-5268
pubmed: 29548011
Annu Rev Cell Dev Biol. 2009;25:355-76
pubmed: 19575643
Semin Cancer Biol. 2021 Oct;75:29-37
pubmed: 34029740
J Exp Clin Cancer Res. 2021 Jul 5;40(1):222
pubmed: 34225773
Nat Rev Mol Cell Biol. 2011 Apr;12(4):246-58
pubmed: 21427766
Acta Physiol (Oxf). 2020 Feb;228(2):e13391
pubmed: 31529760
Science. 2019 Aug 30;365(6456):919-922
pubmed: 31346137
Biochem Soc Trans. 2011 Apr;39(2):658-62
pubmed: 21428957
Transl Lung Cancer Res. 2021 Oct;10(10):3957-3972
pubmed: 34858784
Cancer Med. 2018 Oct;7(10):5130-5144
pubmed: 30239174
Clin Lab. 2020 Jun 1;66(6):
pubmed: 32538051
RNA Biol. 2020 Aug;17(8):1116-1124
pubmed: 32116132
Trends Biochem Sci. 2016 Aug;41(8):679-689
pubmed: 27263052
J Cancer. 2021 Apr 2;12(11):3230-3238
pubmed: 33976732
Cell Physiol Biochem. 2018;49(2):419-431
pubmed: 30153663
Cell Res. 2017 Nov;27(11):1307-1308
pubmed: 28840860
Front Med. 2022 Apr;16(2):216-226
pubmed: 35416630
J Exp Clin Cancer Res. 2018 May 9;37(1):101
pubmed: 29743091
Mol Cancer. 2019 Apr 2;18(1):74
pubmed: 30940133
Signal Transduct Target Ther. 2020 Jun 30;5(1):109
pubmed: 32606362
Mol Ther Nucleic Acids. 2022 Jan 03;27:718-732
pubmed: 35317282
J Transl Med. 2021 Feb 25;19(1):88
pubmed: 33632236
Bioengineered. 2022 Feb;13(2):2087-2098
pubmed: 35030975
FASEB J. 2019 Dec;33(12):13228-13240
pubmed: 31560576
Proc Natl Acad Sci U S A. 2016 May 3;113(18):5071-6
pubmed: 27071132
Development. 1997 Jun;124(12):2463-76
pubmed: 9199372
Cancer Res. 1977 Sep;37(9):3362-6
pubmed: 884680
Stem Cell Res Ther. 2021 Jul 22;12(1):418
pubmed: 34294122
Front Oncol. 2021 Feb 16;10:570916
pubmed: 33665159
Chem Biol Drug Des. 2017 Nov;90(5):730-738
pubmed: 28378898
Int J Mol Sci. 2020 Nov 20;21(22):
pubmed: 33233493
Genome Med. 2021 Feb 9;13(1):20
pubmed: 33563322
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3816-25
pubmed: 26124144
RNA. 2009 Dec;15(12):2147-60
pubmed: 19850906
Nucleic Acids Res. 2018 Jan 4;46(D1):D152-D159
pubmed: 29186503
NPJ Breast Cancer. 2021 Jan 5;7(1):4
pubmed: 33402674
Cancer Lett. 2019 Aug 10;457:60-73
pubmed: 31078732
Nucleic Acids Res. 2021 Jan 8;49(D1):D254-D260
pubmed: 33035346
J Cell Physiol. 2020 Jun;235(6):5318-5327
pubmed: 31919859
RNA Biol. 2017 Oct 3;14(10):1364-1373
pubmed: 27892771
Cancer Cell Int. 2022 Feb 3;22(1):59
pubmed: 35115004
RNA Biol. 2020 Aug;17(8):1081-1091
pubmed: 32597311
Cancer. 1979 Dec;44(6):2120-3
pubmed: 509391
Nucleic Acids Res. 2022 Jan 7;50(D1):D421-D431
pubmed: 34755848
Cancer Res. 2018 Mar 1;78(5):1140-1154
pubmed: 29229607
Pharmaceutics. 2021 Jan 04;13(1):
pubmed: 33406670
Mol Cell. 2012 Nov 30;48(4):509-20
pubmed: 23084833
J Virol. 2014 Apr;88(7):3612-22
pubmed: 24403582
Cells. 2020 Apr 10;9(4):
pubmed: 32290057
Int J Mol Sci. 2018 Feb 08;19(2):
pubmed: 29419808
Am J Cancer Res. 2021 Mar 01;11(3):837-848
pubmed: 33791157