Structural and Functional Attributes of Microrchidia Family of Chromatin Remodelers.
chromatin remodellers
diseases
molecular interactions
protein structure-function
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
30 07 2022
30 07 2022
Historique:
received:
24
01
2022
revised:
10
05
2022
accepted:
27
05
2022
pubmed:
7
6
2022
medline:
8
7
2022
entrez:
6
6
2022
Statut:
ppublish
Résumé
Chromatin remodelers affect the spatio-temporal dynamics of global gene-expression by structurally modulating and/or reorganizing the chromatin. Microrchidia (MORC) family is a relatively new addition to the four well studied families of chromatin remodeling proteins. In this review, we discuss the current understanding of the structural aspects of human MORCs as well as their epigenetic functions. From a molecular and systems-level perspective, we explore their participation in phase-separated structures, possible influence on various biological processes through protein-protein interactions, and potential extra-nuclear roles. We describe how dysregulation/dysfunction of MORCs can lead to various pathological conditions. We conclude by emphasizing the importance of undertaking integrated efforts to obtain a holistic understanding of the various biological roles of MORCs.
Identifiants
pubmed: 35659506
pii: S0022-2836(22)00256-X
doi: 10.1016/j.jmb.2022.167664
pii:
doi:
Substances chimiques
Chromatin
0
Nuclear Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
167664Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Competing Interests All authors declare they have no competing interests.