Obesity prolongs induction times in reptiles.

Anesthesia, Inhalation Anesthetics Animals Isoflurane Obesity Reptiles
Anaesthetic uptake Cardiac shunt Ectotherm Fat MAC

Journal

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
ISSN: 1531-4332
Titre abrégé: Comp Biochem Physiol A Mol Integr Physiol
Pays: United States
ID NLM: 9806096

Informations de publication

Date de publication:
09 2022
Historique:
received: 17 02 2022
revised: 24 05 2022
accepted: 30 05 2022
pubmed: 7 6 2022
medline: 14 7 2022
entrez: 6 6 2022
Statut: ppublish

Résumé

Obesity is common in captive reptiles, and reptiles are increasingly popular as companion animals and in physiological research. Obesity may present a challenge during surgical procedures using inhalation anaesthesia, as the long induction time due to the low reptilian metabolism may increase anaesthetic accumulation in the adipose tissues. This study investigated the impact of obesity on induction and recovery times from inhaled anaesthesia. The temporal change in the partial pressure of isoflurane in different tissues was predicted using a multi-compartment model. Furthermore, as right-to-left shunting can delay anaesthetic uptake and washout, we included an assessment of the combination of cardiac shunting and obesity. The model predictions indicate a clear increase in time to reach 90% equilibration of administered anaesthetic in the brain (T

Identifiants

DOI: 10.1016/j.cbpa.2022.111255 PMID: 35659976
pubmed: 35659976
pii: S1095-6433(22)00113-1
doi: 10.1016/j.cbpa.2022.111255
pii:
doi:

Substances chimiques

Anesthetics 0
Isoflurane CYS9AKD70P

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111255

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Line Kristensen (L)

Section of Zoophysiology, Department of Biology, Aarhus University, 8000, Aarhus C, Denmark. Electronic address: kristensenline.lk@outlook.com.

Christian Lind Malte (CL)

Section of Zoophysiology, Department of Biology, Aarhus University, 8000, Aarhus C, Denmark.

Hans Malte (H)

Section of Zoophysiology, Department of Biology, Aarhus University, 8000, Aarhus C, Denmark.

Tobias Wang (T)

Section of Zoophysiology, Department of Biology, Aarhus University, 8000, Aarhus C, Denmark. Electronic address: https://twitter.com/Tobias_Wang_AU.

Catherine J A Williams (CJA)

Section of Zoophysiology, Department of Biology, Aarhus University, 8000, Aarhus C, Denmark; Ontario Veterinary College, University of Guelph, 50 Stone Road E, Guelph, ON, N1G 2W1, Canada. Electronic address: https://twitter.com/cjaw_art.

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Classifications MeSH

questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Anesthésie générale › Anesthésie par inhalation › Obesity prolongs induction times in reptiles.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Obesity prolongs induction times in reptiles.
questionsmedicales.fr › Eucaryotes › Animaux › Obesity prolongs induction times in reptiles.
questionsmedicales.fr › Composés chimiques organiques › Éthers › Éthers méthyliques › Isoflurane › Obesity prolongs induction times in reptiles.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obesity prolongs induction times in reptiles.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Reptiles › Obesity prolongs induction times in reptiles.