Partial in vivo protection against Peruvian spider Loxosceles laeta venom by immunization with a multiepitopic protein (rMEPLox).
Hyaluronidase
In vivo protection
Loxosceles laeta spider
Metalloprotease
Multiepitopic protein
Sphyngomielinase-D
Journal
Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
14
03
2022
revised:
26
05
2022
accepted:
27
05
2022
pubmed:
7
6
2022
medline:
7
7
2022
entrez:
6
6
2022
Statut:
ppublish
Résumé
Loxoscelism is a serious public health problem in Peru, with approximately 2500 accidents reported per year. To envision alternatives to cope with this health problem, the neutralizing humoral immune response against the lethal effects of Peruvian spider Loxosceles laeta venom was evaluated in a mouse model by immunization with a non-toxic multiepitopic protein (rMEPLox). This immunogen contains epitopes from an astacin-like metalloprotease, a hyaluronidase and a sphingomyelinase-D from Loxosceles intermedia and from SMase-I from L. laeta venoms. In vivo protection assays showed that five out of six mice immunized with rMEPLox (after six injections) resisted to 1.4 LD
Identifiants
pubmed: 35660625
pii: S0041-0101(22)00175-1
doi: 10.1016/j.toxicon.2022.05.044
pii:
doi:
Substances chimiques
Epitopes
0
Spider Venoms
0
Phosphoric Diester Hydrolases
EC 3.1.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-5Informations de copyright
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