Three-dimensional anatomical structure formed by granule cell layer and pyramidal cell layer in human hippocampus.
Granular layer
Human hippocampus
Pyramidal layer
Segmental organization
Three-dimensional structure
Journal
Anatomical science international
ISSN: 1447-073X
Titre abrégé: Anat Sci Int
Pays: Japan
ID NLM: 101154140
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
24
11
2021
accepted:
14
05
2022
pubmed:
7
6
2022
medline:
20
1
2023
entrez:
6
6
2022
Statut:
ppublish
Résumé
In the human hippocampus, the pyramidal layer consists of the inferior aspect of the hippocampus which is organized segmentally. Each segment, together with granule layer of the dentate gyrus, exhibits structural unity. In humans, ellipsoidal protrusions called pyramidal hillocks (PHs), which consist of a thick pyramidal cell layer (PL), are present in the inferior aspect of the hippocampus, and are segmentally organized along a longitudinal axis. It is also known that the granule cell layer (GL) of the dentate gyrus (DG) is not a smooth but undulated structure. However, the cytoarchitectural relationships between the protrusions and undulation have yet to be studied well. Here, we aimed to clarify the three-dimensional cytoarchitecture of the PL and GL of human hippocampus. For that purpose, the GL and PL were three-dimensionally reconstructed from serial sections of human hippocampus stained with hematoxylin and eosin. The GL was shaped as tubing with an opening in the dorsal part, and undulated especially in the medial part, forming digit-like processes. In the base of a digit-like process, protrusions of the GL extended laterally, with longer ones reaching the lateral edge, whereas shorter ones disappeared around the medial 1/3 of the GL. Consequently, the lateral part of the GL was undulated loosely. In the ventral view of the PL, the ellipsoidal PHs were sagittally aligned, whereas in the top view, each PH formed an ellipsoidal trough. Each structural unit was formed by a trough of the PH along the bottom, and had a longer GL protrusion in the upper-center, and shorter GL protrusions located between the longer protrusions and the lateral edge of the GL. A digit-like process extended into a dens. It is concluded that a unit of the PH and the GL comprises the longitudinal segmental formation of the hippocampus.
Identifiants
pubmed: 35661331
doi: 10.1007/s12565-022-00673-8
pii: 10.1007/s12565-022-00673-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-76Subventions
Organisme : Japan Society for the Promotion of Science
ID : 16K08455
Organisme : Japan Society for the Promotion of Science
ID : 19H04212
Organisme : Japan Society for the Promotion of Science
ID : 20K21664
Informations de copyright
© 2022. The Author(s), under exclusive licence to Japanese Association of Anatomists.
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