Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo.

Animals Electrons Protons Radiotherapy Dosage Zebrafish
Electron Flash effect Mean dose rate influence Normal tissue toxicity Proton Flash effect Pulse structure Ultra-high dose rate Zebrafish embryo

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
08 2022
Historique:
received: 24 02 2022
revised: 20 05 2022
accepted: 26 05 2022
pubmed: 7 6 2022
medline: 4 8 2022
entrez: 6 6 2022
Statut: ppublish

Résumé

Continuing recent experiments at the research electron accelerator ELBE at the Helmholtz-Zentrum Dresden-Rossendorf the influence of beam pulse structure on the Flash effect was investigated. The proton beam pulse structure of an isochronous cyclotron (UHDR Relative to the reference a significant protecting Flash effect was observed for all electron beam pulse regimes with less severe damage the higher the mean dose rate of the electron beam. Accordingly, the macro pulsing induced prolongation of treatment time at UHDR The recent findings indicate that the mean dose rate or treatment time are decisive for the normal tissue protecting Flash effect in zebrafish embryo.

Sections du résumé

BACKGROUND AND PURPOSE
Continuing recent experiments at the research electron accelerator ELBE at the Helmholtz-Zentrum Dresden-Rossendorf the influence of beam pulse structure on the Flash effect was investigated.
MATERIALS AND METHODS
The proton beam pulse structure of an isochronous cyclotron (UHDR
RESULTS
Relative to the reference a significant protecting Flash effect was observed for all electron beam pulse regimes with less severe damage the higher the mean dose rate of the electron beam. Accordingly, the macro pulsing induced prolongation of treatment time at UHDR
CONCLUSION
The recent findings indicate that the mean dose rate or treatment time are decisive for the normal tissue protecting Flash effect in zebrafish embryo.

Identifiants

DOI: 10.1016/j.radonc.2022.05.025 PMID: 35661675
pubmed: 35661675
pii: S0167-8140(22)04131-7
doi: 10.1016/j.radonc.2022.05.025
pii:
doi:

Substances chimiques

Protons 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

49-54

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors have nothing to disclose.

Auteurs

Leonhard Karsch (L)

Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Radiooncology - OncoRay, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.

Jörg Pawelke (J)

Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Radiooncology - OncoRay, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany.

Michael Brand (M)

Center for Regenerative Therapies TU Dresden (CRTD), and Cluster of Excellence 'Physics of Life', Technische Universität Dresden, Germany.

Stefan Hans (S)

Center for Regenerative Therapies TU Dresden (CRTD), and Cluster of Excellence 'Physics of Life', Technische Universität Dresden, Germany.

Katalin Hideghéty (K)

ELI-ALPS, ELI-HU Non-Profit Ltd., Szeged, Hungary; Oncotherapy Department, University of Szeged, Hungary.

Jeannette Jansen (J)

Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Elisabeth Lessmann (E)

Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiation Physics, Germany.

Steffen Löck (S)

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Michael Schürer (M)

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany; National Center for Tumor Diseases Dresden (NCT/UCC), Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.

Rico Schurig (R)

Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiation Physics, Germany.

Joao Seco (J)

Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Physics and Astronomy, Heidelberg University, Germany.

Emília Rita Szabó (ER)

ELI-ALPS, ELI-HU Non-Profit Ltd., Szeged, Hungary.

Elke Beyreuther (E)

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiation Physics, Germany. Electronic address: E.Beyreuther@hzdr.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Beam pulse structure and dose rate as...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électrons › Beam pulse structure and dose rate as...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › Beam pulse structure and dose rate as...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Dosimétrie en radiothérapie › Beam pulse structure and dose rate as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Beam pulse structure and dose rate as...