GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton.

Actin Cytoskeleton / metabolism Actins / metabolism Humans Mitochondria / metabolism Nerve Tissue Proteins / metabolism Neuroblastoma / metabolism Pyruvate Dehydrogenase Complex / metabolism

Journal

Communications biology

ISSN: 2399-3642

Titre abrégé: Commun Biol

Pays: England

ID NLM: 101719179

Informations de publication

Date de publication:
03 06 2022

Historique:

received: 24 03 2022

accepted: 11 05 2022

entrez: 6 6 2022

pubmed: 7 6 2022

medline: 9 6 2022

Statut: epublish

Résumé

Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca

Identifiants

DOI: 10.1038/s42003-022-03487-6 PMID: 35662277 PMC: PMC9166793

pubmed: 35662277

doi: 10.1038/s42003-022-03487-6

pii: 10.1038/s42003-022-03487-6

pmc: PMC9166793

doi:

Substances chimiques

Actins 0

GDAP protein 0

Nerve Tissue Proteins 0

Pyruvate Dehydrogenase Complex 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

541

Informations de copyright

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