Stilbenes from the leaves of Cajanus cajan and their in vitro anti-inflammatory activities.
Anti-inflammatory
Cajanus cajan
Fabaceae
Stilbene
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
03
05
2022
revised:
28
05
2022
accepted:
28
05
2022
pubmed:
7
6
2022
medline:
22
6
2022
entrez:
6
6
2022
Statut:
ppublish
Résumé
Eighteen stilbenes (1-18), including six previously undescribed ones (1-6), with diverse modification patterns were isolated from the leaves of edible and medicinal plant Cajanus cajan. Among the new isolates, compounds 1-3 were initially obtained as three racemic mixtures, which were further resolved into three pairs of optically pure enantiomers, respectively, by chiral HPLC. Besides, compounds 8, 10, 11, and 18 were obtained from C. cajan for the first time. The chemical structures and absolute configurations of the new stilbenes were elucidated unambiguously on the basis of extensive spectroscopic analyses, single crystal X-ray crystallographic study, and quantum chemical electronic circular dichroism (ECD) calculations. In addition, the in vitro anti-inflammatory activities of all isolated stilbenes were evaluated. Compounds 2, 9, 10, 11, and 14 exerted moderate suppression of nitric oxide (NO) secretion in lipopolysaccharide (LPS)-induced RAW264.7 cells without exhibiting substantial cytotoxicity.
Identifiants
pubmed: 35662649
pii: S0367-326X(22)00107-1
doi: 10.1016/j.fitote.2022.105229
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Stilbenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105229Informations de copyright
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