Assessing the role of eosinophil-mediated immune response markers in detecting hookworm infection: A case-control study in Kintampo, Ghana.
eosinophil cationic protein
eosinophils‐mediated immune response
eotaxin (CCL11)
hookworm infection
immunoglobulin E
Journal
Health science reports
ISSN: 2398-8835
Titre abrégé: Health Sci Rep
Pays: United States
ID NLM: 101728855
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
21
02
2022
revised:
22
05
2022
accepted:
23
05
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Human hookworm disease caused by This case-control study was carried out in hookworm endemic areas within the Kintampo North Municipality.Forty hookworm-positive subjects and 36 apparently healthy individuals were recruited as cases and controls, respectively. Stool samples were collected for hookworm detection by the Kato-Katz technique and speciation by polymerase chain reaction. Approximately, 5 ml of intravenous blood was used to obtain plasma for the immunological assays. Of eosinophil-mediated immune response markers studied, ECP and CCL11 were significantly higher among hookworm patients compared to controls. Increasing CCL11 ( ECP best predicts eosinophil-mediated immune response for detecting hookworm infection, while CCL11 and eosinophil count better predict the intensity of hookworm. Moreover, the ECP level is a good indicator of hookworm infection and intensity and may require additional investigations to augment current hookworm diagnostic techniques.
Sections du résumé
Background and Aim
UNASSIGNED
Human hookworm disease caused by
Methods
UNASSIGNED
This case-control study was carried out in hookworm endemic areas within the Kintampo North Municipality.Forty hookworm-positive subjects and 36 apparently healthy individuals were recruited as cases and controls, respectively. Stool samples were collected for hookworm detection by the Kato-Katz technique and speciation by polymerase chain reaction. Approximately, 5 ml of intravenous blood was used to obtain plasma for the immunological assays.
Results
UNASSIGNED
Of eosinophil-mediated immune response markers studied, ECP and CCL11 were significantly higher among hookworm patients compared to controls. Increasing CCL11 (
Conclusion
UNASSIGNED
ECP best predicts eosinophil-mediated immune response for detecting hookworm infection, while CCL11 and eosinophil count better predict the intensity of hookworm. Moreover, the ECP level is a good indicator of hookworm infection and intensity and may require additional investigations to augment current hookworm diagnostic techniques.
Identifiants
pubmed: 35662977
doi: 10.1002/hsr2.674
pii: HSR2674
pmc: PMC9165202
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e674Informations de copyright
© 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
PLoS Negl Trop Dis. 2012;6(4):e1582
pubmed: 22545164
J Allergy Clin Immunol. 2007 Jun;119(6):1303-10; quiz 1311-2
pubmed: 17481712
Pharmaceuticals (Basel). 2020 Sep 02;13(9):
pubmed: 32887304
J Stat Softw. 2017 Aug;79:
pubmed: 30686944
Acta Trop. 1996 Dec 16;62(3):171-82
pubmed: 9025985
PLoS Negl Trop Dis. 2009;3(3):e399
pubmed: 19308259
J Allergy Clin Immunol. 2004 Jan;113(1):30-7
pubmed: 14713904
Parasitology. 2003 Dec;127(Pt 6):525-31
pubmed: 14700188
PLoS Negl Trop Dis. 2008;2(11):e331
pubmed: 18982057
Health Sci Rep. 2022 Jun 03;5(4):e674
pubmed: 35662977
Trop Med Int Health. 2000 Dec;5(12):898-905
pubmed: 11169280
Front Immunol. 2014 Feb 14;5:61
pubmed: 24592267
ISRN Pediatr. 2012;2012:168379
pubmed: 23320189
Clin Exp Allergy. 2008 May;38(5):709-50
pubmed: 18384431
Respir Res. 2011 Jan 14;12:10
pubmed: 21235798
J Egypt Soc Parasitol. 2002 Aug;32(2):517-24
pubmed: 12214929
PLoS Negl Trop Dis. 2012;6(4):e1601
pubmed: 22545166
PLoS Negl Trop Dis. 2011 Sep;5(9):e1280
pubmed: 21909439
J Immunol. 2020 Feb 1;204(3):682-693
pubmed: 31871023
Parasite Immunol. 2007 Jul;29(7):347-58
pubmed: 17576364
BMC Infect Dis. 2021 Apr 8;21(1):332
pubmed: 33832450
Korean J Parasitol. 2009 Oct;47 Suppl:S125-31
pubmed: 19885328
J Immunol. 2000 Dec 1;165(11):6447-53
pubmed: 11086084
Front Psychiatry. 2018 Jun 14;9:241
pubmed: 29962972
Nat Rev Dis Primers. 2016 Dec 08;2:16088
pubmed: 27929101
Am J Trop Med Hyg. 2013 Sep;89(3):540-8
pubmed: 23836564
Mol Cell Probes. 1998 Apr;12(2):71-8
pubmed: 9633041
Immunol Rev. 2004 Oct;201:156-67
pubmed: 15361239
PLoS One. 2019 Sep 12;14(9):e0222382
pubmed: 31513658
Cytokine X. 2019 Oct 04;1(4):100014
pubmed: 33604551