Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women.
PTSD symptom clusters
PTSD–posttraumatic stress disorder
cellular aging
sexual assault against woman
telomere–genetics
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
12
2021
accepted:
19
04
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Telomeres are short tandem repeats of "TTAGGG" that protect the chromosome ends from deterioration or fusion of chromosomes. Their repeat length shortens with cell division acting as a biomarker of cellular aging. Traumatic stress events during adulthood or childhood have been associated with posttraumatic stress disorder (PTSD) and short leukocyte telomere length (LTL). This study investigated whether LTL was associated with PTSD in a Brazilian sample of sexually assaulted civilian women at two time points: baseline and 1-year follow-up. At baseline, we assessed 64 women with PTSD following sexual assault (cases) and 60 women with no previous history of sexual trauma or mental disorders (healthy controls - HC). At follow-up visit, 13 persistent PTSD cases, 11 HCs, and 11 PTSD remitters patients were evaluated. PTSD diagnosis and severity were assessed using Mini International Neuropsychiatric Interview (Diagnostic and Statistical Manual of Mental Disorders III/IV criteria) and Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), respectively. LTL was measured using multiplex real-time polymerase chain reaction (PCR). In the baseline analysis, we observed that LTL was associated with re-experiencing symptoms (
Identifiants
pubmed: 35664481
doi: 10.3389/fpsyt.2022.835783
pmc: PMC9161278
doi:
Types de publication
Journal Article
Langues
eng
Pagination
835783Informations de copyright
Copyright © 2022 Carvalho, Coimbra, Xavier, Bugiga, Fonseca, Olff, Polimanti, Mello, Ota, Mello and Belangero.
Déclaration de conflit d'intérêts
RP is paid for their editorial work on the journal Complex Psychiatry. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Physiol Pharmacol. 2008 Dec;59 Suppl 9:169-86
pubmed: 19261979
Asian J Psychiatr. 2013 Feb;6(1):3-21
pubmed: 23380312
World J Biol Psychiatry. 2021 Dec;22(10):792-799
pubmed: 33821766
Front Psychiatry. 2020 Mar 31;11:4
pubmed: 32296346
Dialogues Clin Neurosci. 2011;13(3):251-62
pubmed: 22034252
PLoS One. 2013 Jul 03;8(7):e64762
pubmed: 23843935
JAMA Netw Open. 2019 May 3;2(5):e193447
pubmed: 31050786
Nurs Res. 2014 Jan-Feb;63(1):36-50
pubmed: 24335912
PLoS One. 2018 Feb 7;13(2):e0192222
pubmed: 29415058
JAMA. 2010 Mar 24;303(12):1159-66
pubmed: 20332401
Front Behav Neurosci. 2020 Jan 31;14:6
pubmed: 32082127
Dev Psychopathol. 2011 Nov;23(4):1125-38
pubmed: 22018085
J Trauma Stress. 2018 Oct;31(5):676-686
pubmed: 30338579
Epidemiol Rev. 2013;35:98-111
pubmed: 23258416
Child Abuse Negl. 2015 Jun;44:26-35
pubmed: 25680654
J Affect Disord. 2017 Aug 15;218:322-326
pubmed: 28486180
J Anxiety Disord. 2013 Jan;27(1):33-46
pubmed: 23247200
BMC Public Health. 2018 Feb 13;18(1):250
pubmed: 29439681
Health Place. 2022 Mar;74:102746
pubmed: 35123384
J Psychiatr Res. 2019 Apr;111:83-88
pubmed: 30685566
Harv Rev Psychiatry. 2018 Mar/Apr;26(2):57-69
pubmed: 29016379
Biol Psychiatry. 2021 May 1;89(9):878-887
pubmed: 33276944
Sci Rep. 2019 Feb 5;9(1):1404
pubmed: 30723310
Biol Psychiatry. 2011 Sep 1;70(5):465-71
pubmed: 21489410
Depress Anxiety. 2014 Jun;31(6):494-505
pubmed: 24894802
Nucleic Acids Res. 2009 Feb;37(3):e21
pubmed: 19129229
Neurosci Biobehav Rev. 2015 Aug;55:333-64
pubmed: 25999120
Psychoneuroendocrinology. 2015 Jan;51:506-12
pubmed: 25129579
Clin Psychol (New York). 2012 Sep 1;19(3):
pubmed: 24179316
Life Sci. 2007 Jun 27;81(3):177-87
pubmed: 17570440
Biol Psychiatry. 2013 Jan 1;73(1):15-23
pubmed: 22831981
FEBS Lett. 2005 Feb 7;579(4):859-62
pubmed: 15680963
Mol Psychiatry. 2014 Aug;19(8):855-6
pubmed: 24189343
Health Place. 2014 May;27:120-6
pubmed: 24603009
Front Psychiatry. 2021 Jun 22;12:614735
pubmed: 34239457
Biol Psychiatry. 2010 Mar 15;67(6):531-4
pubmed: 19828140
Addict Behav. 2011 May;36(5):465-9
pubmed: 21315519
Psychol Med. 2020 Oct 23;:1-9
pubmed: 33092657
Depress Anxiety. 2011 Dec 21;28(12):1081-5
pubmed: 22065550
BMC Psychiatry. 2016 Jun 24;16:202
pubmed: 27342048
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Feb;5(2):203-212
pubmed: 31759868
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:275-83
pubmed: 24977331
Cells. 2018 Oct 15;7(10):
pubmed: 30326633
Am J Med Genet B Neuropsychiatr Genet. 2017 Oct;174(7):671-682
pubmed: 28686326
J Biol Chem. 1990 Apr 15;265(11):5919-21
pubmed: 2180936
Trends Psychiatry Psychother. 2020 Jun;42(2):195-206
pubmed: 32696892
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5
pubmed: 15574496
Mol Psychiatry. 2014 Nov;19(11):1156-62
pubmed: 25245500
Ecol Soc. 2013;18(2):16
pubmed: 25170339
Depress Anxiety. 2017 May;34(5):391-400
pubmed: 28380289
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):401-407
pubmed: 28756011
JMIR Res Protoc. 2020 Nov 18;9(11):e19162
pubmed: 33206061
J Trauma Stress. 1995 Jan;8(1):75-90
pubmed: 7712061