α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
liquid-liquid phase separation (LLPS)
synapse
synapsin
synaptic vesicle
synaptic vesicle clustering
α-Synuclein
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
03
2022
accepted:
26
04
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.
Identifiants
pubmed: 35664678
doi: 10.3389/fmolb.2022.891508
pii: 891508
pmc: PMC9159372
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
891508Informations de copyright
Copyright © 2022 Brodin, Milovanovic, Rizzoli and Shupliakov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
EMBO J. 2020 Aug 17;39(16):e104596
pubmed: 32627850
Neuron. 2012 Jul 12;75(1):11-25
pubmed: 22794257
Annu Rev Pathol. 2021 Jan 24;16:465-485
pubmed: 33497259
Curr Opin Neurobiol. 2022 Feb;72:72-79
pubmed: 34653835
Neuroscience. 2009 Jan 12;158(1):204-10
pubmed: 18440714
Annu Rev Biochem. 2011;80:101-23
pubmed: 21438688
Nature. 2012 Mar 07;483(7389):336-40
pubmed: 22398450
Curr Opin Cell Biol. 2022 Apr;75:102068
pubmed: 35279562
J Neurosci. 2011 Dec 7;31(49):18149-54
pubmed: 22159126
Neuron. 2017 Mar 8;93(5):995-1002
pubmed: 28279363
Dev Cell. 2020 Oct 12;55(1):30-44
pubmed: 32726575
Nat Commun. 2018 Feb 19;9(1):712
pubmed: 29459792
Neuron. 2013 Sep 18;79(6):1044-66
pubmed: 24050397
Front Synaptic Neurosci. 2010 Oct 05;2:135
pubmed: 21423521
Clin Geriatr Med. 2020 Feb;36(1):1-12
pubmed: 31733690
J Mol Biol. 2018 Nov 2;430(23):4636-4649
pubmed: 30099026
J Neurosci. 2004 Dec 15;24(50):11368-80
pubmed: 15601943
Front Synaptic Neurosci. 2016 Jan 12;7:19
pubmed: 26793095
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W460-4
pubmed: 17567614
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12057-12062
pubmed: 29078407
J Cell Biol. 1989 May;108(5):1863-72
pubmed: 2497106
Science. 2018 Aug 10;361(6402):604-607
pubmed: 29976799
Science. 2014 May 30;344(6187):1023-8
pubmed: 24876496
Nat Neurosci. 2017 May;20(5):681-689
pubmed: 28288128
J Biol Chem. 2013 Jan 18;288(3):1829-40
pubmed: 23184946
J Neurosci. 2004 Jul 28;24(30):6715-23
pubmed: 15282274
J Cell Biol. 1983 May;96(5):1337-54
pubmed: 6404910
PLoS One. 2010 May 11;5(5):e10589
pubmed: 20485674
Mol Cell. 2019 Mar 7;73(5):971-984.e5
pubmed: 30661983
J Biol Chem. 2011 Jun 10;286(23):20710-26
pubmed: 21489994
Cell. 2016 Jul 28;166(3):651-663
pubmed: 27374333
Cell. 2010 Oct 29;143(3):430-41
pubmed: 21029864
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19474-19483
pubmed: 31506351
Neuron. 2016 Aug 17;91(4):792-807
pubmed: 27537484
Cell Rep. 2020 Feb 25;30(8):2594-2602.e3
pubmed: 32101738
Annu Rev Phys Chem. 2020 Apr 20;71:53-75
pubmed: 32312191
Nat Commun. 2021 Jan 11;12(1):263
pubmed: 33431828
Science. 2017 Sep 22;357(6357):
pubmed: 28935776
J Neurochem. 2019 Sep;150(5):475-486
pubmed: 31269263
Nature. 1996 Jan 25;379(6563):353-7
pubmed: 8552192
Methods Mol Med. 2001;62:67-72
pubmed: 21318768
Neuron. 2010 Apr 15;66(1):37-44
pubmed: 20399727
Biophys J. 2010 Jul 21;99(2):675-84
pubmed: 20643088
Mol Cell. 2021 Jan 7;81(1):13-24.e7
pubmed: 33202250
Nature. 2020 Dec;588(7838):454-458
pubmed: 33208945
Science. 2010 Sep 24;329(5999):1663-7
pubmed: 20798282
Neuron. 1992 Nov;9(5):805-13
pubmed: 1418996
J Cell Sci. 2011 Jan 1;124(Pt 1):133-43
pubmed: 21172823
EMBO J. 2010 Oct 20;29(20):3571-89
pubmed: 20842103
Sci Rep. 2020 Dec 3;10(1):21086
pubmed: 33273508
J Neurosci. 2005 Nov 23;25(47):10913-21
pubmed: 16306404
J Neurosci. 2008 Apr 9;28(15):3925-33
pubmed: 18400891
Mol Biol Cell. 2014 Dec 1;25(24):3926-41
pubmed: 25273557
J Neurosci. 2014 Jul 9;34(28):9364-76
pubmed: 25009269
JACS Au. 2021 Jan 25;1(1):66-78
pubmed: 33554215
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1988-92
pubmed: 2155429
Mol Brain. 2021 Sep 8;14(1):137
pubmed: 34496937
J Cell Biol. 2007 Jul 16;178(2):309-22
pubmed: 17620409
J Neurosci. 2014 Jan 1;34(1):249-59
pubmed: 24381286
Nature. 1995 Jun 8;375(6531):488-93
pubmed: 7777057
Nat Commun. 2020 Jun 1;11(1):2729
pubmed: 32483166
Nat Chem. 2020 Aug;12(8):705-716
pubmed: 32514159
Cell Rep. 2017 Jan 3;18(1):161-173
pubmed: 28052246
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17183-8
pubmed: 21903923
Cell. 2006 Nov 17;127(4):831-46
pubmed: 17110340
J Mol Biol. 2021 Jun 11;433(12):166961
pubmed: 33774037
J Neurosci. 2007 Jun 27;27(26):6868-77
pubmed: 17596435
Nature. 1995 Jun 8;375(6531):493-7
pubmed: 7777058
Traffic. 2004 Jul;5(7):514-28
pubmed: 15180828
J Neurosci. 1988 Aug;8(8):2804-15
pubmed: 3411354
Curr Opin Neurobiol. 2018 Aug;51:119-126
pubmed: 29597140
Brain Res. 2004 Apr 9;1004(1-2):61-72
pubmed: 15033420
J Cell Biol. 2011 Jul 11;194(1):89-103
pubmed: 21746853
J Mol Cell Biol. 2021 Aug 4;13(4):282-294
pubmed: 33386842
J Neurosci. 2011 Sep 28;31(39):13972-80
pubmed: 21957258
Eur J Neurosci. 2012 Oct;36(8):3005-20
pubmed: 22805168
J Neurosci. 2012 Jul 25;32(30):10129-35
pubmed: 22836248
Front Cell Dev Biol. 2021 Nov 26;9:774650
pubmed: 34901020
J Neurosci. 2007 Jan 10;27(2):379-90
pubmed: 17215399