Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies
Kmt2c
MLL3
head and neck squamous cell carcinoma (HNSCC)
hypopharyngeal cancer (HPC)
laryngeal cancer
mutational landscape
next-generation sequencing (NGS)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
09
2021
accepted:
08
04
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Hypopharyngeal cancer is a poorly characterized type of head and neck squamous cell carcinoma (HNSCC) with bleak prognosis and only few studies focusing specifically on the genomic profile of this type of cancer. We performed molecular profiling of 48 HPV (Human Papilloma Virus)-negative tumor samples including 23 originating from the hypopharynx and 25 from the larynx using a targeted next-generation sequencing approach. Among genes previously described as significantly mutated,
Identifiants
pubmed: 35664801
doi: 10.3389/fonc.2022.768954
pmc: PMC9160230
doi:
Types de publication
Journal Article
Langues
eng
Pagination
768954Informations de copyright
Copyright © 2022 Machnicki, Rzepakowska, Janowska, Pepek, Krop, Pruszczyk, Stawinski, Rydzanicz, Grzybowski, Gornicka, Wnuk, Ploski, Osuch-Wojcikiewicz and Stoklosa.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Laryngoscope. 2008 Aug;118(8):1362-71
pubmed: 18496152
Science. 2011 Aug 26;333(6046):1154-7
pubmed: 21798897
Head Neck. 2012 Feb;34(2):270-81
pubmed: 22228621
Nat Methods. 2014 Aug;11(8):783-784
pubmed: 25075903
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Nat Methods. 2014 Feb;11(2):122-3
pubmed: 24481216
Mol Cell. 2017 May 18;66(4):568-576.e4
pubmed: 28483418
Lancet Oncol. 2019 Sep;20(9):1295-1305
pubmed: 31351869
Int J Cancer. 2014 Jan 15;134(2):493-4
pubmed: 23818232
J Cancer Res Clin Oncol. 2020 Feb;146(2):381-389
pubmed: 31960186
Clin Otolaryngol. 2005 Feb;30(1):52-7
pubmed: 15748191
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Nat Genet. 2013 May;45(5):478-86
pubmed: 23525077
Curr Opin Oncol. 2009 May;21(3):194-200
pubmed: 19363341
Nature. 2015 Jan 29;517(7536):576-82
pubmed: 25631445
Cancer Cell. 2018 Dec 10;34(6):893-905.e8
pubmed: 30537512
J Surg Oncol. 2014 Oct;110(5):551-74
pubmed: 25053506
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
Cancer Lett. 2018 Sep 1;431:64-72
pubmed: 29807113
Cell Death Differ. 2020 Aug;27(8):2330-2343
pubmed: 32042099
Front Oncol. 2019 Jul 23;9:666
pubmed: 31396487
Science. 2011 Aug 26;333(6046):1157-60
pubmed: 21798893
Genome Biol. 2011;12(4):R41
pubmed: 21527027
Nature. 2017 Jan 12;541(7636):169-175
pubmed: 28052061
Hum Mutat. 2013 Jan;34(1):57-65
pubmed: 23033316
Genome Res. 2018 Nov;28(11):1747-1756
pubmed: 30341162
Nat Commun. 2017 Nov 24;8(1):1772
pubmed: 29176703
Eur J Cancer. 2015 Oct;51(15):2130-2143
pubmed: 26421817
Tumour Biol. 2015 Feb;36(2):605-13
pubmed: 25273170
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Science. 2020 Mar 13;367(6483):1264-1269
pubmed: 32165588
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
Cancer Cell. 2014 May 12;25(5):652-65
pubmed: 24794707
Oral Oncol. 2011 Apr;47(4):302-7
pubmed: 21397551
J Neuropathol Exp Neurol. 2017 Jan 1;76(1):61-66
pubmed: 28040793
IEEE/ACM Trans Comput Biol Bioinform. 2019 Sep-Oct;16(5):1656-1662
pubmed: 29993813
Eur Arch Otorhinolaryngol. 2018 Jan;275(1):181-189
pubmed: 29080963
EMBO Rep. 2019 Mar;20(3):
pubmed: 30665945
Clin Cancer Res. 2011 Jun 1;17(11):3733-41
pubmed: 21467160
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Nat Genet. 2013 Mar;45(3):253-61
pubmed: 23354438
Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jul;130(1):63-70
pubmed: 32404253
PLoS Comput Biol. 2016 Apr 21;12(4):e1004873
pubmed: 27100738
Nat Genet. 2017 Feb;49(2):180-185
pubmed: 28067913
Nat Genet. 2014 Aug;46(8):866-71
pubmed: 24952746
J Clin Invest. 2020 May 1;130(5):2712-2726
pubmed: 32027624
Nat Genet. 2017 Nov;49(11):1647-1653
pubmed: 28967912
J Exp Clin Cancer Res. 2018 Jul 24;37(1):165
pubmed: 30041665
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Oral Oncol. 2018 Jun;81:35-44
pubmed: 29884412
Nat Med. 2018 May;24(5):556-562
pubmed: 29736026
Nat Cell Biol. 2011 Aug 14;13(10):1244-51
pubmed: 21841793
Nucleic Acids Res. 2016 Jul 8;44(W1):W272-6
pubmed: 27185894
Nature. 2011 Mar 10;471(7337):235-9
pubmed: 21390130
Genes Chromosomes Cancer. 2016 Aug;55(8):626-39
pubmed: 27106868
Nat Med. 2015 Mar;21(3):231-8
pubmed: 25686104
Nat Genet. 2014 May;46(5):467-73
pubmed: 24686850
J Clin Microbiol. 2004 Jul;42(7):3176-84
pubmed: 15243079
Nat Methods. 2014 Apr;11(4):361-2
pubmed: 24681721
Nat Genet. 2014 Mar;46(3):310-5
pubmed: 24487276
Front Oncol. 2020 Jul 28;10:1275
pubmed: 32850388
Nature. 2014 May 1;509(7498):91-5
pubmed: 24670651
Cancer Discov. 2015 Jul;5(7):752-67
pubmed: 26069190
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
Clin Cancer Res. 2018 Dec 15;24(24):6556-6569
pubmed: 30108106
Cancer Lett. 2019 Aug 28;458:56-65
pubmed: 31128216
Cancer Cell. 2016 May 9;29(5):622-637
pubmed: 27165741
Bioinformatics. 2011 Aug 1;27(15):2147-8
pubmed: 21685053
Oncogene. 2018 Aug;37(34):4692-4710
pubmed: 29755131
Oral Oncol. 2016 Apr;55:55-60
pubmed: 26846732
Curr Protoc Bioinformatics. 2013;43:11.10.1-11.10.33
pubmed: 25431634
Carcinogenesis. 2018 Dec 13;39(11):1320-1330
pubmed: 30102337
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Laryngoscope. 2015 Mar;125(3):624-9
pubmed: 25220657
Int J Surg. 2020 Oct;82:249-259
pubmed: 32422386
Clin Cancer Res. 2015 Feb 1;21(3):632-41
pubmed: 25056374
Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20
pubmed: 23315928
Sci Transl Med. 2017 Feb 22;9(378):
pubmed: 28228601
Oncogene. 2008 Jan 10;27(3):274-84
pubmed: 17621269
Bioinformatics. 2019 Jun 1;35(11):1978-1980
pubmed: 30376034
Clin Cancer Res. 2019 Sep 15;25(18):5584-5594
pubmed: 31196855
BMC Cancer. 2017 Dec 28;17(1):898
pubmed: 29282038
Nucleic Acids Res. 2018 Jan 4;46(D1):D1062-D1067
pubmed: 29165669
Nat Protoc. 2009;4(7):1073-81
pubmed: 19561590
J Hematol Oncol. 2020 Dec 4;13(1):165
pubmed: 33276800