BCG Moreau Polish Substrain Infections in Patients With Inborn Errors of Immunity: 40 Years of Experience in the Department of Immunology, Children's Memorial Health Institute, Warsaw.
BCG Moreau vaccine
BCG infection
Inborn Errors of Immunity
NK cells
disseminated BCG infection
susceptibility to BCG infection
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
12
2021
accepted:
22
03
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
We aimed to assess BCG (Bacillus Calmette-Guérin) complications in patients with Inborn Errors of Immunity (IEI), according to the inherited disorders and associated immunological defects, as well as the different BCG substrains. We studied adverse reactions to the locally-produced BCG Moreau vaccine, analyzed in patients with IEI diagnosed between 1980 and 2020 in the Department of Immunology, Children's Memorial Health Institute (CMHI), Warsaw. These results were compared with previously published studies. Significantly fewer disseminated BCG infections (BCGosis) were found in 11 of 72 (15%) SCID (Severe Combined Immunodeficiency) NK (Natural Killer)-phenotype patients, when compared with the 119 out of 349 (34%) ( The BCG Moreau substrain vaccine, produced in Poland since 1955, showed genetic differences with its parental Brazilian substrain together with a superior clinical safety profile in comparison with the other BCG substrains, with no BCGosis in patients with IEI other than SCID and MSMD. Our data also confirmed significantly fewer cases of BCGosis and deaths caused by BCG infection in patients with SCID with this vaccine substrain. Finally, they confirmed the protecting role of NK cells, probably
Identifiants
pubmed: 35664873
doi: 10.3389/fped.2022.839111
pmc: PMC9161164
doi:
Types de publication
Journal Article
Langues
eng
Pagination
839111Informations de copyright
Copyright © 2022 Bernatowska, Pac, Heropolitańska-Pliszka, Pietrucha, Dąbrowska-Leonik, Skomska-Pawliszak, Bernat-Sitarz, Krzysztopa-Grzybowska, Wolska-Kuśnierz, Bohynikova, Augustynowicz, Augustynowicz-Kopeć, Korzeniewska-Koseła, Wieteska-Klimczak, Książyk, Jackowska, van den Burg, Casanova, Picard and Mikołuć.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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