Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
27 Nov 2022
27 Nov 2022
Historique:
pubmed:
7
6
2022
medline:
7
6
2022
entrez:
6
6
2022
Statut:
epublish
Résumé
Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 infection and autoimmune disorders, but they target different chemokines than those in COVID-19. Monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential. Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and predict lack of long COVID.
Identifiants
pubmed: 35664993
doi: 10.1101/2022.05.23.493121
pmc: PMC9164443
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : P01 AI138938
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151698
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111825
Pays : United States
Commentaires et corrections
Type : UpdateIn
Références
Nat Med. 2021 Sep;27(9):1607-1613
pubmed: 34163090
N Engl J Med. 2018 May 24;378(21):2010-2021
pubmed: 29791828
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Methods Enzymol. 1997;287:233-50
pubmed: 9330326
Nat Immunol. 2022 Feb;23(2):210-216
pubmed: 35027728
Cell. 2022 Mar 3;185(5):916-938.e58
pubmed: 35216673
EClinicalMedicine. 2021 Aug;38:101019
pubmed: 34308300
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
J Autoimmun. 2004 Aug;23(1):63-73
pubmed: 15236754
Clin Exp Immunol. 2008 Jan;151(1):42-50
pubmed: 18005364
Nature. 2021 Jul;595(7866):283-288
pubmed: 34010947
Eur J Immunol. 1995 Jan;25(1):64-8
pubmed: 7531149
Lancet Respir Med. 2021 Jun;9(6):655-664
pubmed: 33930329
Curr Opin Immunol. 2001 Dec;13(6):670-5
pubmed: 11677088
J Clin Immunol. 1999 Sep;19(5):293-9
pubmed: 10535605
Nature. 2022 Jul;607(7917):97-103
pubmed: 35255492
J Exp Med. 2020 Nov 2;217(11):
pubmed: 32692348
Nature. 2021 May;593(7859):424-428
pubmed: 33767445
Nat Med. 2020 Jun;26(6):842-844
pubmed: 32398875
Front Microbiol. 2021 Jun 23;12:698169
pubmed: 34248921
Nat Commun. 2020 Jun 15;11(1):3031
pubmed: 32541785
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
J Immunol. 2001 Jan 15;166(2):1272-84
pubmed: 11145710
Cell Mol Immunol. 2018 Apr;15(4):324-334
pubmed: 29375126
J Clin Invest. 2015 Jun;125(6):2194-202
pubmed: 25938780
Nature. 2016 Dec 15;540(7633):458-461
pubmed: 27926736
Science. 2020 Oct 23;370(6515):
pubmed: 32972995
Nat Protoc. 2016 Oct;11(10):1908-1923
pubmed: 27658009
Comput Struct Biotechnol J. 2021;19:976-988
pubmed: 33558827
EBioMedicine. 2021 Sep;71:103561
pubmed: 34455390
Cell Rep Med. 2020 Dec 26;2(1):100166
pubmed: 33521697
Science. 2020 Nov 27;370(6520):
pubmed: 32994364
Cell. 2017 May 04;169(4):597-609.e11
pubmed: 28475892
Ticks Tick Borne Dis. 2021 Mar;12(2):101638
pubmed: 33360384
Nature. 2022 Nov;611(7934):139-147
pubmed: 36044993
Nature. 2019 Jan;565(7739):318-323
pubmed: 30542158
Biochemistry. 2000 Nov 21;39(46):14075-81
pubmed: 11087354
Annu Rev Immunol. 2012;30:429-57
pubmed: 22224772
Nature. 2021 Mar;591(7848):92-98
pubmed: 33307546
Annu Rev Immunol. 1999;17:657-700
pubmed: 10358771
Nat Immunol. 2022 Feb;23(2):194-202
pubmed: 35105985
J Glob Antimicrob Resist. 2021 Mar;24:90-92
pubmed: 33242672
J Immunol. 2008 Jan 1;180(1):647-54
pubmed: 18097067
Science. 2020 Oct 23;370(6515):
pubmed: 32972996
Cell Mol Life Sci. 2012 May;69(9):1435-45
pubmed: 22045557
EMBO J. 1997 Dec 1;16(23):6996-7007
pubmed: 9384579
Clin Transl Sci. 2020 Nov;13(6):1077-1086
pubmed: 32315487
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
J Immunol Methods. 2008 Jan 1;329(1-2):112-24
pubmed: 17996249
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):
pubmed: 35193979
Cells. 2019 Dec 27;9(1):
pubmed: 31892200
Cell. 2022 Mar 3;185(5):881-895.e20
pubmed: 35216672
Bioinformatics. 2015 Oct 15;31(20):3356-8
pubmed: 26069265
J Clin Invest. 2005 Sep;115(9):2480-8
pubmed: 16127458
Cell. 2020 Dec 10;183(6):1479-1495.e20
pubmed: 33171100
Clin Exp Immunol. 2009 Jan;155(1):1-15
pubmed: 19076824
Nature. 2021 Dec;600(7889):472-477
pubmed: 34237774
Sci Immunol. 2022 Jan 07;7(67):eabm5505
pubmed: 34995097
Blood. 2001 Apr 1;97(7):1920-4
pubmed: 11264152
Front Immunol. 2022 Feb 07;13:817829
pubmed: 35197981
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
BMJ. 2022 Feb 16;376:e068993
pubmed: 35172971
Science. 2022 Mar 11;375(6585):1122-1127
pubmed: 35271343
Nucleic Acids Res. 2018 Jul 2;46(W1):W296-W303
pubmed: 29788355
Lancet Infect Dis. 2010 Dec;10(12):875-85
pubmed: 21109174
Sci Transl Med. 2020 Nov 18;12(570):
pubmed: 33139519
Nature. 2020 Aug;584(7821):463-469
pubmed: 32717743
Immunol Cell Biol. 2015 Apr;93(4):372-83
pubmed: 25708536
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W34-40
pubmed: 23671333
Cell. 2021 Dec 22;184(26):6243-6261.e27
pubmed: 34914922
Pharmacol Rev. 2013 Nov 11;66(1):1-79
pubmed: 24218476
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
Nat Immunol. 2022 Feb;23(2):275-286
pubmed: 35102342
Nat Med. 2022 Mar;28(3):583-590
pubmed: 35132265
J Immunol. 2017 Jan 1;198(1):184-195
pubmed: 27895171
Methods Enzymol. 2016;570:87-118
pubmed: 26921943
Autoimmun Rev. 2022 Mar;21(3):103012
pubmed: 34896650
Cell Death Differ. 2022 Oct;29(10):1891-1900
pubmed: 36071155
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Sci Immunol. 2021 Aug 19;6(62):
pubmed: 34413139
Curr Biol. 1997 Sep 1;7(9):652-60
pubmed: 9285716
Nat Commun. 2022 Jan 25;13(1):446
pubmed: 35078982
Nature. 2021 May;593(7860):564-569
pubmed: 33780969
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Nat Commun. 2021 Sep 14;12(1):5417
pubmed: 34521836
Sci Transl Med. 2021 Sep 22;13(612):eabh2624
pubmed: 34429372
Front Immunol. 2016 May 19;7:183
pubmed: 27242790
J Exp Med. 2010 Feb 15;207(2):299-308
pubmed: 20123959