Paraneoplastic neurological syndrome with positive anti-Hu and anti-Yo antibodies: A case report.
Anti-Hu antibody
Anti-Yo antibody
Breast cancer
Case report
Intravenous immunoglobulin
Paraneoplastic syndrome
Small cell lung cancer
Journal
World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806
Informations de publication
Date de publication:
06 May 2022
06 May 2022
Historique:
received:
08
09
2021
revised:
05
11
2021
accepted:
14
03
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
ppublish
Résumé
Paraneoplastic neurological syndrome (PNS) is a rare complication in patients with cancer. PNS can affect the central, peripheral, autonomic nervous system, neuromuscular junction, or muscles and cause various neurological symptoms. Anti-Yo antibody-positive neurological paraneoplasms and anti-Hu antibody-positive neurological paraneoplasms are common, but coexistence of both types has not been described in the literature. Here we present a rare case of paraneoplastic neuropathy occurring in both breast and lung cancers. A 55-year-old woman was admitted to our hospital with unsteadiness while walking. The patient had a history of breast cancer two years previously. Chest computed tomography revealed a 4.6 cm × 3.6 cm mass in the right lung, which was diagnosed as small-cell lung cancer (SCLC). Blood test was positive for anti-Yo antibodies, and the cerebrospinal fluid was positive for both anti-Yo and anti-Hu antibodies, and the neurological symptoms were considered to be related to the paraneoplasm. The patient was treated with a course of intravenous immunoglobulin, without noticeable improvement. After being discharged from hospital, the patient underwent regular chemotherapy for SCLC and periodic reviews. The patient's neurological symptoms continued to deteriorate at the follow-up visit in April 2021. This case suggests the possibility of two types of tumors appearing simultaneously with two paraneoplastic antibodies. The clinical appearance of two or more paraneoplastic tumors requires additional attention.
Sections du résumé
BACKGROUND
BACKGROUND
Paraneoplastic neurological syndrome (PNS) is a rare complication in patients with cancer. PNS can affect the central, peripheral, autonomic nervous system, neuromuscular junction, or muscles and cause various neurological symptoms. Anti-Yo antibody-positive neurological paraneoplasms and anti-Hu antibody-positive neurological paraneoplasms are common, but coexistence of both types has not been described in the literature.
CASE SUMMARY
METHODS
Here we present a rare case of paraneoplastic neuropathy occurring in both breast and lung cancers. A 55-year-old woman was admitted to our hospital with unsteadiness while walking. The patient had a history of breast cancer two years previously. Chest computed tomography revealed a 4.6 cm × 3.6 cm mass in the right lung, which was diagnosed as small-cell lung cancer (SCLC). Blood test was positive for anti-Yo antibodies, and the cerebrospinal fluid was positive for both anti-Yo and anti-Hu antibodies, and the neurological symptoms were considered to be related to the paraneoplasm. The patient was treated with a course of intravenous immunoglobulin, without noticeable improvement. After being discharged from hospital, the patient underwent regular chemotherapy for SCLC and periodic reviews. The patient's neurological symptoms continued to deteriorate at the follow-up visit in April 2021.
CONCLUSION
CONCLUSIONS
This case suggests the possibility of two types of tumors appearing simultaneously with two paraneoplastic antibodies. The clinical appearance of two or more paraneoplastic tumors requires additional attention.
Identifiants
pubmed: 35665124
doi: 10.12998/wjcc.v10.i13.4190
pmc: PMC9131235
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4190-4195Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: There are no conflicts of interest related to this report.
Références
Brain. 2003 Jun;126(Pt 6):1409-18
pubmed: 12764061
Brain. 2000 Jul;123 ( Pt 7):1481-94
pubmed: 10869059
Isr Med Assoc J. 2001 Feb;3(2):94-103
pubmed: 11344832
Neurology. 1994 Jan;44(1):140-7
pubmed: 8290049
Mayo Clin Proc. 1990 Nov;65(11):1423-31
pubmed: 2232897
Clin Immunol. 2019 Feb;199:29-36
pubmed: 30543927
N Engl J Med. 2003 Oct 16;349(16):1543-54
pubmed: 14561798
Breast. 2003 Jun;12(3):203-7
pubmed: 14659327
Oxf Med Case Reports. 2018 Jul 09;2018(7):omy034
pubmed: 30002861
Front Neurol. 2019 Nov 26;10:1236
pubmed: 31849812
BMC Neurol. 2019 Nov 6;19(1):273
pubmed: 31694559
World J Clin Oncol. 2014 Aug 10;5(3):197-223
pubmed: 25114839
Neurology. 1985 Apr;35(4):538-43
pubmed: 2984600
Oncoimmunology. 2017 Nov 27;7(2):e1395125
pubmed: 29308329
Breast Cancer. 2006;13(2):202-4
pubmed: 16755118
J Clin Neurol. 2020 Oct;16(4):530-546
pubmed: 33029958
Neurology. 1991 Nov;41(11):1757-64
pubmed: 1944905
Breast J. 2003 Sep-Oct;9(5):417-9
pubmed: 12968965
Neuron. 2009 Oct 15;64(1):123-32
pubmed: 19840554
Sci Rep. 2016 Dec 01;6:38216
pubmed: 27905561