Inhibition of Serine Proteases as a Novel Therapeutic Strategy for Abdominal Pain in IBS.
irritable bowel syndrome
protease inhibitors
protease-activated receptors
proteases
visceral hypersensitivity
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
02
2022
accepted:
26
04
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Serine proteases are heavily present in the gastrointestinal tract where they are essential in numerous physiological processes. An imbalance in the proteolytic activity is a central mechanism underlying abdominal pain in irritable bowel syndrome (IBS). Therefore, protease inhibitors are emerging as a promising therapeutic tool to manage abdominal pain in this functional gastrointestinal disorder. With this review, we provide an up-to-date overview of the implications of serine proteases in the development of abdominal pain in IBS, along with a critical assessment of the current developments and prospects of protease inhibitors as a therapeutic tool. In particular, we highlight the current knowledge gap concerning the identity of dysregulated serine proteases that are released by the rectal mucosa of IBS patients. Finally, we suggest a workflow with state-of-the-art techniques that will help address the knowledge gap, guiding future research towards the development of more effective and selective protease inhibitors to manage abdominal pain in IBS.
Identifiants
pubmed: 35665224
doi: 10.3389/fphys.2022.880422
pii: 880422
pmc: PMC9161638
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
880422Informations de copyright
Copyright © 2022 Decraecker, Boeckxstaens and Denadai-Souza.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2986-3000
pubmed: 31002149
Gut. 2014 May;63(5):753-60
pubmed: 23911555
Molecules. 2011 Feb 21;16(2):1739-48
pubmed: 21339709
Sci Rep. 2018 May 18;8(1):7834
pubmed: 29777136
Dig Dis Sci. 2012 Jan;57(1):58-64
pubmed: 21800160
Pain. 2009 Nov;146(1-2):121-9
pubmed: 19674841
Gastroenterology. 2021 Jan;160(1):99-114.e3
pubmed: 32294476
Gut. 2012 Nov;61(11):1610-8
pubmed: 21900548
Gut. 2005 Jun;54(6):867-74
pubmed: 15888798
Pharmacology. 2018;102(5-6):233-243
pubmed: 30134249
Chem Biol Drug Des. 2018 Jul;92(1):1387-1392
pubmed: 29495100
World J Gastroenterol. 2016 Aug 21;22(31):7111-23
pubmed: 27610021
Eur J Pharmacol. 1992 Nov 13;223(1):83-9
pubmed: 1478260
Gut. 2016 Jul;65(7):1215-24
pubmed: 27196587
Gastroenterology. 2016 Apr;150(4):875-87.e9
pubmed: 26752109
Aliment Pharmacol Ther. 2002 Mar;16(3):407-13
pubmed: 11876693
J Pharmacol Exp Ther. 1992 Apr;261(1):181-90
pubmed: 1560364
Nature. 2021 Feb;590(7844):151-156
pubmed: 33442055
Gastroenterology. 2004 Mar;126(3):693-702
pubmed: 14988823
Int J Mol Sci. 2021 Oct 02;22(19):
pubmed: 34639054
J Gastroenterol. 2009;44(7):666-74
pubmed: 19430717
Front Endocrinol (Lausanne). 2014 May 13;5:67
pubmed: 24860547
Chem Sci. 2018 Jan 16;9(8):2113-2129
pubmed: 29719685
Nat Rev Drug Discov. 2006 Sep;5(9):785-99
pubmed: 16955069
World J Gastroenterol. 2014 Jan 28;20(4):1005-20
pubmed: 24574773
J Pharmacol Sci. 2004 Mar;94(3):277-85
pubmed: 15037813
Trends Biochem Sci. 2009 Sep;34(9):453-63
pubmed: 19726197
Gastroenterology. 2013 Mar;144(3):570-579.e3
pubmed: 23142231
J Proteome Res. 2017 Feb 3;16(2):1014-1026
pubmed: 28052195
Gastroenterology. 2011 Dec;141(6):2088-2097.e1
pubmed: 21875497
Nat Methods. 2012 Nov;9(11):1095-100
pubmed: 23023596
Life Sci. 2016 Mar 1;148:254-9
pubmed: 26874028
Br J Pharmacol. 2002 Mar;135(5):1101-6
pubmed: 11877315
Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G42-53
pubmed: 15746211
J Crohns Colitis. 2020 Sep 7;14(8):1149-1161
pubmed: 32090263
Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G338-G349
pubmed: 30629470
Front Neurosci. 2012 Sep 12;6:133
pubmed: 22988431
Gut. 2020 Jan;69(1):62-73
pubmed: 30923071
Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15;302(2):G260-6
pubmed: 22052012
Gastroenterology. 2009 Oct;137(4):1425-34
pubmed: 19596012
Gut. 2021 May;70(5):970-981
pubmed: 33272979
Exp Brain Res. 2009 Jun;196(1):53-65
pubmed: 19396590
J Can Assoc Gastroenterol. 2019 Apr;2(1):6-29
pubmed: 31294724
Nat Rev Genet. 2003 Jul;4(7):544-58
pubmed: 12838346
J Neurogastroenterol Motil. 2016 Oct 30;22(4):558-574
pubmed: 27431236
Pain. 2018 Jul;159(7):1257-1267
pubmed: 29554016
Ther Apher Dial. 2016 Apr;20(2):197-204
pubmed: 26771066
J Physiol. 2007 Feb 1;578(Pt 3):715-33
pubmed: 17124270
Dig Dis Sci. 2004 Jan;49(1):96-101
pubmed: 14992442
Chem Rev. 2005 Nov;105(11):4056-72
pubmed: 16277371
J Clin Invest. 2007 Mar;117(3):636-47
pubmed: 17304351
Am J Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G81-91
pubmed: 19875705
Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G307-16
pubmed: 11804852
Int J Neuropsychopharmacol. 2009 May;12(4):553-9
pubmed: 18976544
World J Gastroenterol. 2017 Mar 28;23(12):2106-2123
pubmed: 28405139
Neurogastroenterol Motil. 2010 Mar;22(3):312-e84
pubmed: 19706070
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2518-23
pubmed: 24550277
J Pharm Pharmacol. 2015 Feb;67(2):244-54
pubmed: 25515402
Gut. 2017 Oct;66(10):1767-1778
pubmed: 28096305
Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G635-G648
pubmed: 28385695
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 1;317(3):G363-G372
pubmed: 31290688
J Biol Chem. 2014 Sep 26;289(39):27215-27234
pubmed: 25118282
Neurogastroenterol Motil. 2012 Mar;24(3):274-82, e111
pubmed: 22129370
Dig Dis Sci. 2008 Jan;53(1):175-80
pubmed: 17551835
Eur J Pharmacol. 2011 Mar 11;654(3):289-94
pubmed: 21237151
Br J Pharmacol. 2018 Sep;175(17):3516-3533
pubmed: 29911328
Int J Dev Neurosci. 1998 Jun-Jul;16(3-4):187-97
pubmed: 9785115
J Biol Chem. 2015 May 29;290(22):13875-87
pubmed: 25878251
Eur J Pharmacol. 2011 Sep 30;667(1-3):169-74
pubmed: 21645509
Adv Med Sci. 2011;56(2):158-64
pubmed: 22112433
Front Psychiatry. 2020 Nov 11;11:509681
pubmed: 33262709
Nat Rev Drug Discov. 2010 Sep;9(9):690-701
pubmed: 20811381
Pain. 2009 Jul;144(1-2):209-17
pubmed: 19450926
Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13
pubmed: 22044612
Pflugers Arch. 2015 Apr;467(4):687-701
pubmed: 24906497
Pharmaceutics. 2021 May 29;13(6):
pubmed: 34072320
J Neurosci. 2004 May 5;24(18):4293-9
pubmed: 15128843
PLoS One. 2018 Mar 12;13(3):e0193943
pubmed: 29529042
Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):3-10
pubmed: 26702845
Neurogastroenterol Motil. 2007 Jan;19(1 Suppl):29-46
pubmed: 17280584
Microb Cell Fact. 2015 Feb 26;14:26
pubmed: 25889561
Pain. 2006 Jul;123(1-2):179-86
pubmed: 16630696
Clin Nutr. 2013 Feb;32(1):51-8
pubmed: 22727545
Anal Bioanal Chem. 2008 Jun;391(3):1063-71
pubmed: 18392693
Mol Cell Proteomics. 2019 May;18(5):968-981
pubmed: 30705125
Sci Rep. 2019 Sep 16;9(1):13295
pubmed: 31527638
Gut Liver. 2016 May 23;10(3):382-90
pubmed: 26446924
Gastroenterology. 2015 Aug;149(2):433-44.e7
pubmed: 25911511
J Gastroenterol. 2014 May;49(5):799-805
pubmed: 23645119
Curr Neuropharmacol. 2013 Dec;11(6):598-605
pubmed: 24396336
Inflamm Bowel Dis. 2011 Feb;17(2):645-54
pubmed: 20848521
Gastroenterology. 2016 Feb 19;:
pubmed: 27144617
Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16531-16535
pubmed: 28940795
EBioMedicine. 2022 Feb;76:103856
pubmed: 35152152
J Med Chem. 2007 Dec 27;50(26):6638-46
pubmed: 18052026
Dig Dis Sci. 2009 Jul;54(7):1532-41
pubmed: 19337833
Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1;320(6):G1131-G1141
pubmed: 33949199
Gut. 2009 Oct;58(10):1333-41
pubmed: 19324867
J Physiol. 2006 Sep 1;575(Pt 2):555-71
pubmed: 16793902