Fecal Microbiota and Human Intestinal Fluid Transplantation: Methodologies and Outlook.
donor
fecal microbiota transplantation
gut microbial therapeutics
human intestinal fluid transplantation
methodologies
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
12
2021
accepted:
11
04
2022
entrez:
6
6
2022
pubmed:
7
6
2022
medline:
7
6
2022
Statut:
epublish
Résumé
Fecal microbiota transplantation (FMT) is a therapy that involves the transplantation of healthy human fecal microorganisms into the gut of patients to rebuild or consolidate the intestinal microecology. It has been utilized in many diseases. However, FMT had a limited effect on patients with small intestinal diseases because of the unique ecological characteristics of the microorganisms. Thus, we proposed a new microecology transplantation therapy called human intestinal fluid transplantation (HIFT). Human intestinal fluid can be collected through a nasojejunal tube and be made into capsules using the freeze-dried powder method. In addition, strict standards for donor screening and management have been established. We are currently developing a high-standard HIFT preparation system and conducting high-quality clinical studies to validate the safety and efficacy of HIFT combined with FMT.
Identifiants
pubmed: 35665355
doi: 10.3389/fmed.2022.830004
pmc: PMC9158325
doi:
Types de publication
Journal Article
Langues
eng
Pagination
830004Informations de copyright
Copyright © 2022 Chen, Zhiliang, Jiaqu, Xiaoqiong, Shaoyi, Chunlian, Yinmei, Bo, Di, Hongliang, Ning, Qiyi and Huanlong.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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