Accuracy of real-time PCR and digital PCR for the monitoring of total HIV DNA under prolonged antiretroviral therapy.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
04 06 2022
Historique:
received: 12 12 2021
accepted: 21 04 2022
entrez: 6 6 2022
pubmed: 7 6 2022
medline: 9 6 2022
Statut: epublish

Résumé

Total HIV DNA is a standard marker to monitor the HIV reservoir in people living with HIV. We investigated HIV DNA quantification accuracy by a real-time PCR kit (qPCR) and digital PCR (dPCR) method within the same set of primers and probes. Among 48 aviremic patients followed for up to 7 years with qPCR, the mean coefficient of variation of total HIV DNA between two successive measurements was 77% (± 0.42log

Identifiants

pubmed: 35665775
doi: 10.1038/s41598-022-13581-8
pii: 10.1038/s41598-022-13581-8
pmc: PMC9167282
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9323

Informations de copyright

© 2022. The Author(s).

Références

PLoS Pathog. 2019 Jun 20;15(6):e1007868
pubmed: 31220191
Pathogens. 2021 Nov 20;10(11):
pubmed: 34832672
BMC Bioinformatics. 2014 Aug 22;15:283
pubmed: 25147026
Sci Rep. 2017 May 25;7(1):2409
pubmed: 28546538
Sci Rep. 2017 Dec 1;7(1):16799
pubmed: 29196729
Anal Chem. 2014 May 6;86(9):4387-94
pubmed: 24684191
Retrovirology. 2019 Nov 11;16(1):32
pubmed: 31711503
J Virus Erad. 2016 Jul 01;2(3):162-9
pubmed: 27482456
PLoS One. 2015 Oct 02;10(10):e0139510
pubmed: 26431315
Anal Chem. 2015 Sep 1;87(17):8925-31
pubmed: 26235706
J Clin Microbiol. 2015 Feb;53(2):699-701
pubmed: 25502524
J Antimicrob Chemother. 2020 Jul 1;75(7):1943-1949
pubmed: 32259255
Sci Rep. 2017 Apr 26;7(1):1209
pubmed: 28446770
PLoS One. 2014 Jan 21;9(1):e85999
pubmed: 24465831
Retrovirology. 2018 Jan 30;15(1):16
pubmed: 29378600
PLoS One. 2017 Oct 19;12(10):e0186101
pubmed: 29049331
Nat Med. 2016 Aug;22(8):839-50
pubmed: 27400264
Clin Chem. 2020 Aug 1;66(8):1012-1029
pubmed: 32746458
Science. 1987 Nov 6;238(4828):800-2
pubmed: 3313729
Anal Bioanal Chem. 2015 Jul;407(19):5827-34
pubmed: 26022094
J Clin Microbiol. 2004 Nov;42(11):5189-98
pubmed: 15528714
J Virol. 2014 Sep 1;88(17):10056-65
pubmed: 24965451
J Immunol. 2010 Feb 1;184(3):1604-16
pubmed: 20042588
STAR Protoc. 2021 Oct 11;2(4):100885
pubmed: 34693363
J Med Virol. 2017 Nov;89(11):2047-2050
pubmed: 28617961
PLoS One. 2016 May 05;11(5):e0153317
pubmed: 27149415
Nat Med. 2003 Jun;9(6):727-8
pubmed: 12754504
Trends Biotechnol. 2019 Jul;37(7):761-774
pubmed: 30654913
J Clin Virol. 2019 Aug;117:61-67
pubmed: 31229934
J Clin Virol. 2021 Jun;139:104822
pubmed: 33930698
PLoS One. 2013;8(4):e55943
pubmed: 23573183
J Exp Med. 1986 Jul 1;164(1):280-90
pubmed: 3014036
J Transl Med. 2020 Feb 24;18(1):95
pubmed: 32093678
Sci Rep. 2015 Sep 09;5:13811
pubmed: 26350506
Clin Infect Dis. 2014 Nov 1;59(9):1312-21
pubmed: 25073894
J Infect Dis. 2015 Nov 1;212(9):1361-5
pubmed: 25877550
Clin Microbiol Rev. 2016 Oct;29(4):859-80
pubmed: 27559075
J Med Virol. 2009 Feb;81(2):217-23
pubmed: 19107966
PLoS Pathog. 2013 Feb;9(2):e1003174
pubmed: 23459007
J Antimicrob Chemother. 2013 May;68(5):1169-78
pubmed: 23335199
Methods. 2018 Feb 1;134-135:98-105
pubmed: 29197654
J Immunol. 1988 Feb 15;140(4):1117-22
pubmed: 2449497
Retrovirology. 2018 Apr 3;15(1):30
pubmed: 29615133
Methods Mol Biol. 2018;1768:25-43
pubmed: 29717436
Retrovirology. 2016 Aug 11;13(1):55
pubmed: 27515378
J Int AIDS Soc. 2018 Sep;21(9):e25185
pubmed: 30375818

Auteurs

Constance Renault (C)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Antilles University, Montpellier, France.

Karine Bolloré (K)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Antilles University, Montpellier, France.

Amandine Pisoni (A)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Antilles University, Montpellier, France.
CHU de Montpellier, Montpellier, France.

Camille Motto-Ros (C)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Antilles University, Montpellier, France.

Philippe Van de Perre (P)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Antilles University, Montpellier, France.
CHU de Montpellier, Montpellier, France.

Jacques Reynes (J)

IRD UMI 233, INSERM U1175, Montpellier University, Montpellier, France.
Infectious Diseases Department, CHU de Montpellier, Montpellier, France.

Edouard Tuaillon (E)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, Etablissement Français du Sang, Antilles University, Montpellier, France. e-tuaillon@chu-montpellier.fr.
CHU de Montpellier, Montpellier, France. e-tuaillon@chu-montpellier.fr.

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