Defucosylated Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Exerted Antitumor Activities in Mouse Xenograft Models of Canine Mammary Gland Tumor.

Animals Antibodies, Monoclonal / pharmacology Antibody-Dependent Cell Cytotoxicity Antineoplastic Agents / pharmacology CHO Cells Cell Line, Tumor Cricetinae Cricetulus Dogs ErbB Receptors / genetics Female Heterografts Immunoglobulin G Mammary Glands, Animal Mammary Neoplasms, Animal / drug therapy Mice Xenograft Model Antitumor Assays
ADCC CDC EGFR antitumor activity canine breast cancer monoclonal antibody

Journal

Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955

Informations de publication

Date de publication:
Jun 2022
Historique:
pubmed: 7 6 2022
medline: 28 6 2022
entrez: 6 6 2022
Statut: ppublish

Résumé

The epidermal growth factor receptor (EGFR) contributes to tumor malignancy through gene amplification and/or protein overexpression. In our previous study, we developed an anti-human EGFR (hEGFR) monoclonal antibody, clone EMab-134 (mouse IgG

Identifiants

DOI: 10.1089/mab.2022.0009 PMID: 35666554
pubmed: 35666554
doi: 10.1089/mab.2022.0009
doi:

Substances chimiques

Antibodies, Monoclonal 0
Antineoplastic Agents 0
Immunoglobulin G 0
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

142-149

Auteurs

Tomohiro Tanaka (T)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Tomokazu Ohishi (T)

Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Japan.
ORCID: 0000-0002-9039-4474

Masaki Saito (M)

Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Hiroyuki Suzuki (H)

Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Mika K Kaneko (MK)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Manabu Kawada (M)

Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Japan.

Yukinari Kato (Y)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
ORCID: 0000-0001-5385-8201

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Cytotoxicité à médiation cellulaire dépendante des anticorps › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Structures anatomiques de l'animal › Glandes mammaires animales › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Maladies de l'animal › Tumeurs mammaires de l'animal › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Defucosylated Anti-Epidermal Growth Factor...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Defucosylated Anti-Epidermal Growth Factor...