Elution with 1,2-Hexanediol Enables Coupling of ICPMS with Reversed-Pase Liquid Chromatography under Standard Conditions.


Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
21 06 2022
Historique:
pubmed: 7 6 2022
medline: 23 6 2022
entrez: 6 6 2022
Statut: ppublish

Résumé

The inductively coupled plasma mass spectrometry (ICPMS) has been attracting increasing attention for many applications as an element-selective chromatographic detector. A major and fundamental limitation in coupling ICPMS with liquid chromatography is the limited compatibility with organic solvents, which has so far been addressed via a tedious approach, collectively referred to as the "organic ICPMS mode", that can decrease detection sensitivity by up to 100-fold. Herein, we report 1,2-hexanediol as a new eluent in high-performance liquid chromatography-ICPMS which enables avoiding the current limitations. Unlike commonly used eluents, 1,2-hexanediol was remarkably compatible with ICPMS detection at high flow rates of 1.5 mL min

Identifiants

pubmed: 35666989
doi: 10.1021/acs.analchem.2c01769
pmc: PMC9218959
doi:

Substances chimiques

Glycols 0
Hexanes 0
Indicators and Reagents 0
Arsenic N712M78A8G
1,2-hexanediol TR046Y3K1G

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8802-8810

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Auteurs

Bassam Lajin (B)

Institute of Chemistry, Analytical Chemistry for the Health and Environment, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria.

Joerg Feldmann (J)

Institute of Chemistry, TESLA (Trace Element Speciation Laboratory), University of Graz, Universitaetsplatz 1, 8010 Graz, Austria.

Walter Goessler (W)

Institute of Chemistry, Analytical Chemistry for the Health and Environment, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria.

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Classifications MeSH