Zinc improves antibacterial, anti-inflammatory and cell motility activity of chitosan for wound healing applications.
Antibacterial activity
Chelation process
Chitosan‑zinc complex
Wound healing
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
31 Jul 2022
31 Jul 2022
Historique:
received:
17
03
2022
revised:
27
05
2022
accepted:
31
05
2022
pubmed:
7
6
2022
medline:
24
6
2022
entrez:
6
6
2022
Statut:
ppublish
Résumé
We report the successful preparation and characterization of chitosan-Zn complex (ChiZn) in the form of films, intended to enhance the biological performance of chitosan by the presence of Zn as antibacterial agent and biologically active ion. The influence of Zn chelation on morphology and structure of chitosan was assessed by scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and infrared spectroscopy. The biodegradability study of ChiZn showed a sustained release of Zn up to 2 mg/mL. No toxic response was observed toward stromal cell line ST-2 in indirect contact with the ChiZn films. The dissolution product of ChiZn showed improved wound closure (88% closure) compared to the positive control group (70% closure). Moreover, ChiZn exhibited antibacterial activity against S. aureus together with a slight increase (~30%) in the secretion of VEGF and moderate decrease in nitric oxide evolution. Our findings indicate that ChiZn could be used as a safe and effective wound healing agent.
Identifiants
pubmed: 35667458
pii: S0141-8130(22)01193-X
doi: 10.1016/j.ijbiomac.2022.05.199
pmc: PMC9240323
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Inflammatory Agents
0
Chitosan
9012-76-4
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
845-857Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
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